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Infographic: Building personalized cancer vaccines

Elaine Mardis, Jasreet Hundal | 
To create an individualized cancer vaccine, researchers must identify cancer-specific peptides called neoantigens, then use a cell-, protein-, or nucleic ...

Which is more important to the gut microbiome? Genetics or environment?

Nicoletta Lanese | 
Genetics hold far more sway over the mouse microbiome than transient environmental exposures, researchers reported July 26 in Applied and ...
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Can these turtle embryos change their sex by finding warmer or cooler spots within their eggs?

Katarina Zimmer | 
At 27.9 °C, roughly equal numbers of female and male turtles will emerge from the nests of the Chinese pond ...
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Fighting cancer by stimulating the immune system with injections directly into the tumor

Emma Yasinski | 
This past April, Mount Sinai oncologist Joshua Brody and his team announced a clinical trial that delivers immune modulators directly ...
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Human-monkey chimeras created in China in quest to grow transplantable human organs

Nicoletta Lanese | 
An international team of researchers has created embryos containing both human and monkey cells, the Spanish newspaper El País reported July ...
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Priming the body’s immune system with personalized cancer vaccines

Elaine Mardis, Jasreet Hundal | 
In 2014, at Washington University School of Medicine in St. Louis, six melanoma patients received infusions of an anticancer vaccine ...
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Stem cell therapies could treat diabetes by helping the body boost insulin production

Eric Bender | 
Each year, 40,000 people in the United States are diagnosed with type 1 diabetes, an auto­immune disease that wipes out ...
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Viewpoint: AI promises to revolutionize personalized medicine. Now we need ‘clinical validation’.

Eric Topol | 
Machines can now be trained to see things humans cannot, and likely never will.  ... From obviating the need to ...
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Microbiome manipulation could improve our heart health, but it’s not a ‘magic solution’

Shawna Williams | 
“Is the fountain of youth in the gut microbiome?” This provocative question popped up a few months back, not in ...
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Infographic: Separating hype from reality on the benefits of intermittent fasting

Bob Grant | 
Scientists are further detailing both the underlying metabolic dynamics and interesting physiological phenomena aside from weight loss as they study ...
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Why comatose infants make ideal test subjects for brain-reviving technology

Alan Kadish, John Loike | 
A recent Nature paper describing an artificial blood perfusion used in an attempt to restore brain function after pigs were ...
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Treating food allergies by tweaking the microbiome? Trials offer ‘promising but mixed results’

Jef Akst | 
These days, there is little doubt that the body’s resident bacteria have a big say in how the immune system ...
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Chasing links between mental illness and microbes living in our guts

Ashley Yeager | 
“If you would have asked a neuroscientist 10 years ago whether they thought the gut microbiota could be linked to ...
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Infographic: Quantum ‘tricks’ influence photosynthesis, other biological functions

Catherine Offord | 
ENZYME CATALYSIS: A TUNNEL THROUGH THE BARRIER Traditional theories of enzyme catalysis hold that the proteins speed up reactions by ...
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Facing Ebola outbreak, Uganda approves 3 experimental treatments

Catherine Offord | 
Health authorities in Uganda have approved the use of three experimental treatments against Ebola in the country. The decision comes ...
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Are we fighting diseases wrong? Researcher suggests a better approach is building tolerance to infection

Ashley Yeager | 
[Researcher Janelle] Ayres was running the experiment to determine what causes genetically identical mice to respond differently to the same ...
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Infographic: These supercomputers mimic human brains to boost computing power

Sandeep Ravindran | 
Neuromorphic hardware takes a page from the architecture of animal nervous systems, relaying signals via spiking that is akin to ...

Video: See how the brain makes memories

Nicholas Turk-Browne | 
Watch Princeton University’s Nicholas Turk-Browne describe his research on how the human brain makes, stores and adjusts memories. Read full, ...
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Stem cell treatment could create ‘living drug’ against cancer tumors

Chia-Yi Hou | 
In a first-of-its-kind clinical trial, a natural killer cell immunotherapy derived from induced pluripotent stem cells is being tested for ...
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Defining life: Why we need to identify the boundary between living things and AI robots

John Loike, Robert Pollack | 
They’re advancing artificial intelligence (AI) to create next-gen personalized robots that can read human emotions in real time. What will ...
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‘Reverse engineering’ our brains with silicon chips could help us understand consciousness

Sandeep Ravindran | 
The fact that computers “think” very differently than our brains do actually gives them an advantage when it comes to ...
5-5-2019 future artificial intelligence

Building artificial brains to help us understand our own

Bob Grant | 
You’d think that overseeing an entire issue of The Scientist focused on artificial intelligence would cause my mind to wander far into ...

Off-target RNA mutations: Why this ‘more precise genome-editing’ technique needs improvement

Catherine Offord | 
Base editors designed to convert one DNA nucleotide to another may also perform large numbers of unwanted edits to RNA, ...
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Cancer has a male bias and we’re just starting to understand why

Jef Akst | 
More than half of neurooncologist Josh Rubin’s pediatric brain cancer patients over his 25-year career have been boys. … About a ...
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Monitoring biodiversity: Project seeks to catalog arctic life through ‘DNA Barcoding’

Phil Jaekl | 
[Molecular biologist Inger Greye] Alsos is currently taking part in the formidable task of genetically identifying not just all the ...
4-8-2019 tasmaniandevil

When cancer becomes contagious: Seeking better understanding of rare transmissible forms of the disease

Katarina Zimmer | 
The untrained eye likely wouldn’t have noticed, but doctoral student Ruth Pye immediately spotted something unusual about the way the cells were ...

Can CAR-T cell therapy tackle solid tumors too?

Kerry Grens | 
Last summer, [Cecelia] Barron’s cancer went from stage 2 to stage 3 oligodendroglioma. Behnam Badie, her surgeon at City of Hope, ...
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CRISPR’s challenge: It’s still easier to subtract genes than it is to add them

Anna Nowogrodzki | 
Almost always, building something is harder than tearing it down. Similarly, knocking in genes poses a greater challenge than knocking ...