It is probably cliché at this point to mention that the world seems to be getting crazier/faster/more stressful. Stress can manifest in many different ways, including obesity, substance dependence, and depression. A new study led by Ronald Duman of Yale University has discovered how a particular gene regulates how the brain responds to stressors. The ability to regulate the expression of this gene could protect against neuronal damage. The results were published in the journal Nature Medicine.
Depression is much more than just feeling down about things; it can actually cause changes to the brain over time. Major depressive disorder (MDD) and stress have been associated with atrophy of neurons. Stress is believed to increase expression of the REDD1 gene that in turn inhibits mTORC1. The function of mTORC1 is to regulate protein synthesis based on nutrients and energy. Increased levels of REDD1 have been shown to reduce synaptic connections in the brain, which can bring on symptoms of depression.
Related on the SLP
Read the full, original story: Study Reveals New Approach For Blocking Neuronal Damage From Stress
