Same genes can make someone happy or depressed, depending on environment

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Combining research on genetics and cognitive biasesโ€”our mental โ€œfiltersโ€ for interpreting the worldโ€”will contribute to a greater understanding of mental disorders and could lead to improved therapies, Elaine Fox of University of Oxford and Chris Beevers of the University of Texas at Austin suggest in a perspective published yesterday (July 19) in Molecular Psychiatry.

โ€œWe suggest that while no gene โ€˜causesโ€™ mental ill health, some genes can make people more sensitive to the effects of their environmentโ€”for better and for worse,โ€ Fox said in a statement.

Studies show that cognitive bias can greatly influence sensitivity to oneโ€™s environment…for example, inducing a negative attentional bias can increase a personโ€™s response to a stressful situation, whereas reducing the negative bias can decrease that personโ€™s stress response.

Genetics studies have identified variants, such as the serotonin transporter-linked polymorphic region (5-HTTLPR) short (S) allele, which make people more sensitive to their environments. People with this S allele are more likely than people with the long (L) variant to develop psychiatric disorders after experiencing adversity in childhood, studies have shown.

Read full, original post:ย Study: Influence of Genetics on Mental Health Depends on Environment

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