Stomachs grown from stem cells could yield secrets of digestion


Stomach-related diseases are common, affecting millions of people. An estimated 25 percent of individuals in the United States are affected by gastrointestinal disorders.

Principal investigator Jim Wells, Ph.D., director of the Pluripotent Stem Cell Facility at Cincinnati Children’s, has made it his mission to develop reliable, consistent models of the organs involved in digestion – specifically, the intestines, stomach, pancreas, and esophagus.

His team has designed ways to use pluripotent stem cells to grow organs.

[Study link here]

[T]he team recently designed a method to grow the stomach’s corpus/fundus region. This is the uppermost section of the stomach, near to the cardiac sphincter where the organ is attached to the esophagus.

Additionally, now that the team has access to both a stomach and intestine model, they hope to study how nutrients are absorbed, how the body controls digestion, and a range of gut disorders.

As technology advances and the resultant organoids become ever more naturalistic, research into gastrointestinal conditions will become easier, quicker, and more productive.

The GLP aggregated and excerpted this blog/article to reflect the diversity of news, opinion, and analysis. Read full, original post: Organoid advances: How to grow a stomach in the lab