Adding 24 new mutations to breast cancer risk calculations

Peripheral Neuropathy is Common After Breast Cancer Treatment x

Twenty-four previously unknown mutations that raise a woman’s risk of developing breast cancer have been identified by scientists. The ‘ground-breaking’ findings [February 28] provide an answer to thousands of victims of whom the disease runs in their family.

Cancer Research UK states that fewer than three per cent of cancers are caused by an inherited faulty gene. It says there are four known genes that can raise the risk of breast cancer, including the BRCA gene – famously carried by by Angelina Jolie.

But the new discovery, led by Professor Melissa Southey, could potentially extend that to 28, if further research confirms the findings. She said: ‘For the majority of women who undergo genetic testing, there is no explanation for their breast cancer predisposition.

‘This ground-breaking work is not only helpful for women from families with many cases of breast cancer. ‘It will improve breast cancer risk prediction for all women, and pave the way for the development of epigenetic therapeutics for breast cancer.’

They discovered the epigenetic changes can be passed down through generations without changing the DNA that makes the genes.

The study is one of the first to scan the genome for places where DNA methylation is heritable, and is the first to apply this to familial breast cancer.

Editor’s note: Read the full study

Read full, original post: Twenty-four previously unknown mutations that raise a woman’s risk of breast cancer have been identified following ground-breaking research

Outbreak
Outbreak Daily Digest
Biotech Facts & Fallacies
Talking Biotech
Genetics Unzipped
ft covidresponseus feature

Video: Viewpoint: The US wrote the global playbook on the coronavirus and then ignored it

A year ago, the United States was regarded as the country best prepared for a pandemic. Our government had spent ...
mag insects image superjumbo v

Disaster interrupted: Which farming system better preserves insect populations: Organic or conventional?

A three-year run of fragmentary Armageddon-like studies had primed the journalism pumps and settled the media framing about the future ...
dead bee desolate city

Are we facing an ‘Insect Apocalypse’ caused by ‘intensive, industrial’ farming and agricultural chemicals? The media say yes; Science says ‘no’

The media call it the “Insect Apocalypse”. In the past three years, the phrase has become an accepted truth of ...
globalmethanebudget globalcarbonproject cropped x

Infographic: Cows cause climate change? Agriculture scientist says ‘belching bovines’ get too much blame

A recent interview by Caroline Stocks, a UK journalist who writes about food, agriculture and the environment, of air quality ...
organic hillside sweet corn x

Organic v conventional using GMOs: Which is the more sustainable farming?

Many consumers spend more for organic food to avoid genetically modified products in part because they believe that “industrial agriculture” ...
benjamin franklin x

Are most GMO safety studies funded by industry?

The assertion that biotech companies do the research and the government just signs off on it is false ...
gmo corn field x

Do GMO Bt (insect-resistant) crops pose a threat to human health or the environment?

Bt is a bacterium found organically in the soil. It is extremely effective in repelling or killing target insects but ...
favicon

Environmental Working Group: EWG challenges safety of GMOs, food pesticide residues

Known by some as the "Environmental Worrying Group," EWG lobbies for tighter GMO legislation and famously puts out annual "dirty dozen" list of fruits and ...
m hansen

Michael Hansen: Architect of Consumers Union ongoing anti-GMO campaign

Michael K. Hansen (born 1956) is thought by critics to be the prime mover behind the ongoing campaign against agricultural biotechnology at Consumer Reports. He is an ...
News on human & agricultural genetics and biotechnology delivered to your inbox.
Optional. Mail on special occasions.
Send this to a friend