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Are we close to gene therapy in the womb?

, | | July 27, 2018
gene therapy womb
This article or excerpt is included in the GLP’s daily curated selection of ideologically diverse news, opinion and analysis of biotechnology innovation.

[Recently] scientists reported that they were able to treat a serious genetic disorder in the womb — in mice. It sounds like science fiction, but this type of treatment may not be far away for humans…

The Verge spoke to New York University bioethicist Arthur Caplan about this trial, the challenges of gene therapy, and why ethics boards will want to take a very close look.

[Verge:] In your opinion, how far away is fetal gene therapy in humans? Are we talking a decade? Two decades?

[Caplan:] I would say 10 years.

[Verge:] What about the downsides of the prenatal approach?

[Caplan:] One is that you get a third person involved in terms of the risk of research: the mom. Trying to administer gene therapy around her can put somebody at risk. And until we’re really sure from many more studies, we can’t put moms at risk even if it would help the fetus.

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[Verge:] What are the considerations we need to think about before this becomes viable?

You’ll need close review by ethics committees because if you ask moms, if they’re willing to take a risk to help their child, most moms are probably going to say “yeah.” But they may not be able to process the risk or understand the dangers well.

Read full, original post: Scientists treated a mouse’s genetic disorder in the womb — here’s what’s next

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