How the right diet could slow cancer growth through ‘metabolic therapy’

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Doctors are starting to think more about specific nutrients that feed tumor cells. That is, how what we eat affects how cancers grow—and whether there are ways to potentially “starve” cancer cells.

Methionine is made in normal cells—out of homocysteine, folate, and vitamin B12. However, many types of cancer cells lack the enzyme that makes cellular manufacturing of methionine possible. So they require extra methionine from outside the body—via food we eat—for survival. Cut off that supply, and it should help to slow the tumor without starving the person.

[In May, biologist Jason] Locasale and his colleagues at Duke released findings showing that restricting methionine decreased tumor growth in mice and human subjects.

Because cancer is a term that encapsulates many different diseases—with different changes in different metabolic pathways in different cells in different parts of the body—no single metabolic therapy is right for every person. What makes one cancer grow more slowly could conceivably hasten another. Just as avoiding excessive sugar is crucial for people with diabetes, lest they lose their vision and feet, sugar can save the life of a person with critical hypoglycemia.

Read full, original post: You Can’t ‘Starve’ Cancer, but You Might Help Treat It With Food

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