Alzheimer’s research is at a dead end. Here are 5 unexplored treatment routes

c alzheimer s disease spl
Credit: Jessica Wilson/Science Photo Library

It is time to go back to basics. I have been a scientist involved in Alzheimer’s research for three decades, part of large projects investigating families with a high risk of Alzheimer’s, prevention strategies and the physiology of damage to brain cells that is part of the illness. I and my colleagues, who work across many scientific and medical disciplines, believe that we need to reexamine the fundamental physiology and biology of Alzheimer’s, as well as reassess the contents of databases and our lab refrigerators for clues that we may have overlooked.

There are at least five potentially fruitful and timely research directions—areas based on important discoveries made in the past several years—that can extend our knowledge, and I believe that they are quite likely to yield insights needed to find effective treatments. These areas range from malfunctions in the way brain cells get rid of problem proteins, to damage caused by inflammation, to trouble with the ways that cells send electrical signals to one another. These are different domains, but in a person they overlap to create illness in the brain, and individually or in tandem they may lie behind the terrible damage done by Alzheimer’s.

Related article:  Gene therapy could offer 'one-time genetic tune-up' for Alzheimer's patients

Read the original post

Outbreak Daily Digest
Biotech Facts & Fallacies
Talking Biotech
Genetics Unzipped
Infographic: What are mRNA COVID-19 vaccines and how do they work?

Infographic: What are mRNA COVID-19 vaccines and how do they work?

As of 1 December 2020, thirteen vaccines have reached the final stage of testing: where they are being given to ...

Environmental Working Group: EWG challenges safety of GMOs, food pesticide residues

Known by some as the "Environmental Worrying Group," EWG lobbies ...
m hansen

Michael Hansen: Architect of Consumers Union ongoing anti-GMO campaign

Michael K. Hansen (born 1956) is thought by critics to be ...
News on human & agricultural genetics and biotechnology delivered to your inbox.
glp menu logo outlined

Newsletter Subscription

Optional. Mail on special occasions.
Send this to a friend