The development of a method for genome editing based on CRISPRโCas9 technology was awarded The Nobel Prize in Chemistry in 2020, less than a decade after the discovery of all principal molecular components of the system. For the first time in history a Nobel prize was awarded to two women, Emmanuelle Charpentier and Jennifer Doudna, who made key discoveries in the field of DNA manipulation with the CRISPRโCas9 system, so-called โgenetic scissorsโ. It is difficult to overestimate the importance of the technique as it enables one not only to manipulate genomes of model organisms in scientific experiments, and modify characteristics of important crops and animals, but also has the potential of introducing revolutionary changes in medicine, especially in treatment of genetic diseases.
The first experimental information about the mechanism of action of the CRISPR system was obtained in 2007 in the studies of two French food scientists, Rodolphe Barrangou and Philippe Horvath, who worked with yoghurt cultures of bacteriaย Streptococcus thermophilus for the Danish company Danisco.
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In the coming years the scientific community will watch with interest the development of legislation and ethical principles in the application of the CRISPRโCas9 system in genome editing, as well as in what other areas of science this promising technology will find its application.
