Using a novel approach, researchers have discovered a genetic variant that may contribute to the muscle pain and weakness experienced by some statin users, according to a study published in Nature August 28. Under statin-treated conditions, the variant affects expression of the gene for glycine amidinotransferase (GATM), which controls the synthesis rate of creatine, a molecule muscles use for energy.
“The authors used a really unique approach for trying to understand why some people might respond differently [to statins],” said Deepak Voora, a physician-scientist studying pharmacogenetics at Duke University, who was not involved in the research. “That approach will have implications for studying other drugs.”
Read the full, original story here: Gene a Pain for Statin Users
