Seeking alternative to fossil fuels, high-yielding heat and cold resistant biofuel crop potential genetic goldmine

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Six years ago, jatropha—an inedible, drought-resistant plant that produces a high-quality oil—was “the next big thing in biofuel,” because its oil can be refined into low-carbon jet fuel or diesel fuel.  But it fell out of favor because of the financial crisis and its low seed yields.

Since then, scientists at SGB, a San Diego based biotech company, have sequenced the plant’s genome and traditionally bred different lines—successfully producing a domesticated plant with up to 900 percent yield increase of the oil-producing seeds.

SGB has also discovered a “potential genetic gold mine”—traits that make certain strains of the plant resistant to extreme heat or cold.

There are plans to plant 250,000 acres of jatropha in Brazil, India and other countries expected to eventually produce about 70 million gallons of fuel a year. That has attracted the interest of energy giants, airlines and other multinational companies seeking alternatives to fossil fuels. They see jatropha as a hedge against spikes in petroleum prices and as a way to comply with government mandates that require the use of low-carbon fuels.

Read the full, original story: Start-Up Uses Plant Seeds for a Biofuel

UK Guardian botched ‘suicide gene’ story: ‘Terminator seeds’ will not usher in agricultural judgment day

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Following renewed campaigning by anti-GM groups, a recent article in the Guardian disseminated widely discredited myths surrounding the genetic use restriction techniques (GURT)—or “terminator seeds,” as they are widely known—which are sterile in order to restrict the spread of new genes that have been introduced into the target plant.

The Guardian wrongly stated that new legislation under consideration in Brazil could lead to “suicide seeds” that might “threaten the livelihoods of millions of small farmers around the world.” But the truth is very different to this media sensationalism. Brazil is considering relaxing regulations that prohibit research on GURT. However, this would be applied to pharmaceuticals, not food crops. It is aimed in particular at allowing scientists to examine whether the technology could have biosafety applications – applications that would safeguard the environment against the unintended release and spread of modified genes.

A continued ban on GURT may sound sensible and precautionary, but could harm the potential of researchers to develop lifesaving vaccines and environmentally beneficial crops.

Read the full, original story: Terminator seeds will not usher in an agricultural judgment day

In GMO debate, ‘right to know’ is empty mantra

The right to know is an empty mantra, three words that sound like they are pursuing freedom and information.  However, at their root there is no desire to know–just a desire to believe.
Case 1.  Hofstra Debate Follow Up: The debate at Hofstra was quite one sided from my perspective. One side was about fear, Gish gallops and bad activist information, the other side was tethered with science. One of the debaters was Bhavani Jaroff, a local chef, radio personality and food activist.  Her debate style was to discuss the most shocking activist statements, parroting garbage science and bad conclusions, following the party line with great precision. She stood firmly on Seralini’s rat paper being retracted because of Monsanto, stood by the veracity of the data, and also used the widely debunked Aris and Leblanc “Bt in the umbilical cords and pregnant women” shock language.

I offered to explain the science and walk her through the papers that were the foundation of the evidence in her presentation.  My offer was sincere.  From the little bit I knew about Bhavani I completely anticipated resounding cooperation, that she’d be thrilled to have time to discuss how a scientist reviews literature and determines that it is flawed.

The email I got blew me away.  It started with how we’d have to “agree to disagree because I love the work of Jeffrey Smith and Vandana Shiva”.  She then noted how science is not always right and cited margarine and DDT. She also reminded me that she can’t understand why someone would want to block another’s right to know.
There you have it.  It frames my argument perfectly. I’m all for people having a right to know.  But if you want to know, you have to want to know facts.  You have to demand to know reality.  You have to desire to learn science.

Read full, original story: Demanding a Right to Know

China GMO trade war: Distillers corn grain caught in crossfire, rejected

China has turned away about 2,000 tons of U.S. dried distillers grain (DDG), a corn by-product, and more rejections are expected in coming weeks as Beijing imposes strict checks over an unapproved genetically modified strain. The move follows the rejection of more than half a million tons of U.S. corn after authorities detected the presence of MIR 162, a GMO variety developed by Syngenta AG and not approved for import by China’s agriculture ministry.

Officials say more rejections are likely after China’s General Administration of Quality Supervision, Inspection and Quarantine (CIQ) this week issued a notice to local authorities asking them to step up checks for MIR 162 in DDG cargoes.

“Before, authorities were just checking on selective shipments, but now all shipments will have to be tested and a large volume may be turned away,” says a trader with a major state-owned trading house.

Strict testing for MIR 162 comes as Beijing seeks to curb cheap corn imports and support domestic prices for the grain, industry sources have said.

Read the full, original story: China turns away US distillers grains over GMO, more rejections expected

IVF parents choose girls, to reduce risk of autism

Parents are increasingly asking to choose the sex of their children in an attempt to lower their baby’s risk of diseases and disorders ranging from cancer to autism, IVF doctors say.

Figures from one of Sydney’s top IVF clinics show about one in 20 parents seeking embryo screening are looking to have a female baby to reduce their risk of autism.

The question is, what is the best thing for that woman: continuing to try on her own and miscarrying versus doing IVF and testing the embryos? We can’t know for sure that everybody definitely benefits.

Fertility experts say the issue is the tip of the iceberg with a huge range of tests becoming available. Some clinics in the US now offer testing for up to 600 different genetic markers.

Read the full, original story: Why IVF parents are choosing girls over boys

India environment minister to back more GM crops in January

India’s new environment minister Veerappa Moily has indicated he will push to overturn the blockage on GMO crops instituted by former ministers. Moily’s support is expected to pave the way for the government to submit an affidavit in the Supreme Court i January acquiescing to field trials of GM food crops on a conditional basis. Field trials have been on hold for genetically modified rice, wheat, maize and castor.

Read full, original story: Veerappa Moily to seed a change, likkely to approve GM food crops in India

Genetics of forgetting a face

One in three people have inherited a genetic variation that impairs their ability to remember faces, according to a study that could explain why some individuals recall everyone they have ever met while others have difficulty recognising their own relatives.

The study was carried out on nearly 200 families with an autistic child as part of research into genetic influences on the childhood disorder, which is linked with an inability to recognise faces as part of normal development.

However, the scientists believe that the findings have a wider significance by explaining – at least to some extent – the wide variation in the ability of the general population to recognise faces, whether of total strangers they have seen just once, or of close friends and relatives.

Read the full, original story: Never forget a face? Scientists unlock genetics that cause autism sufferers’ memory struggle

Genetically modified crops key to India’s food security

India’s population will grow to 1.3 billion by 2017, so current agricultural output needs to be doubled against odds like changing climatic conditions, declining ratio of arable land to population and water getting scarcer.

This brings into the picture genetically modified crops, which can strengthen food security in India. GM crops are more robust against biotic and abiotic stresses, can resist disease, insects and weeds. They can also have the potential to resist droughts, floods and climatic change conditions.

Income from genetically modified Bt cotton among small farm households in India made a positive impact on food security and dietary quality, suggesting transgenic crops can be important in food security strategy.

But the role of GM crops for food security remains the subject of controversy. The negative perception is despite no adverse impact reported from any part of the US where GM crops have been in use for over two decades. The issue should be approached in light of the scientific proof and the unsubstantiated claims should be discredited.

Genome analysis of cervical cancer suggests new treatments

Researchers have made a breakthrough when it comes to cervical cancer. They’ve completed a comprehensive genomic analysis of cervical cancer in two patient populations. The study identified recurrent genetic mutation not previously found, including at least one for which targeted treatments have been approved for other forms of cancer. The findings could be huge when it comes to the treatment of cervical cancer.

The scientists identified 13 mutations that occurred frequently enough across the samples to be considered significant in cervical cancer. Eight of these mutations hadn’t been linked to the disease previously.

Read the full, original story: Scientists Complete Genomic Analysis of Cervical Cancer: Possible New Treatments

Insurance coverage for genetic counseling varies from state to state

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In the 21st century we have tremendous amounts of genetic data and analysis, and those data are used in medicine every day. But only some people can have access to or do anything with this knowledge. There is a patchwork of coverage across the United States. Depending on which state someone lives in, a genetic predisposition for cancer can either be a death sentence or a guide to proper preventive care.

Insurance coverage should not determine whether a person gets tested and treated. Access to genetic information is a matter of social justice. Preventing cancer is a matter of life or death.

Read the full, original story: Is Your State Legislature Waiting for You to Get Cancer?

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Irish potato farmers, facing blight scare, look to GMOs but EU turns blind eye

GM is important for Ireland. The country’s staple pototao crop is being threatened. Farmers typically spray 10-20 times against blight; organic farmers use the dangerous fungicide called Bordeaux mix, which releases toxic copper into the environment. Teagasc, Ireland’s agricultural agency, is testing blight-resistant GM potatoes, and it would be relatively simple to use biotechnology to make potatoes blight-resistant. The new GM varieties would need much less or even no spraying. Can one imagine a “greener” project?

Over the last 40 years, genetic modification has revolutionized fundamental biology, medicine, agriculture and forensic science. Europe has been a laggard. The political establishment has adopted a highly politicized regulatory system that has made it almost impossible to grow GM crops in Europe. While US farmers have benefited by $78 billion (1996-2010), European farmers and consumers have been denied the use of this innovative science for nearly 20 years.

Read the full, original story: Ireland losing out because of irrational hostility to GM

When it comes to human brain, size isn’t everything

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At three pounds, the human brain is gigantic relative to our body size. Our closest living relatives, chimpanzees, have brains that are only a third as big. Scientists have long suspected that the size of the brain directly correlates to intelligence. But new research shows that size isn’t everything.

In a new paper, Harvard neuroscientists Randy L. Buckner and Fenna M. Krienen offer a powerful yet simple explanation about how the human brain evolved to be so powerful. In our smaller-brained ancestors, the researchers argue, neurons were tightly tethered in a relatively simple pattern of connections. When our ancestors’ brains expanded, those tethers ripped apart, enabling our neurons to form new circuits, leading to increasingly intelligent behavior, such as using stone tools and making cave paintings.

Dr. Buckner and Dr. Krienen call their idea the tether hypothesis. Their paper appears in the December issue of the journal Trends in Cognitive Sciences.

Read the full, original story: In the Human Brain, Size Really Isn’t Everything

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In hyped claim organic milk is healthier, activist science meets bungled reporting

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For the health-obsessed media, a study touting the alleged benefits of drinking organic milk is a made-for-headlines event and a bonanza for the ‘natural food’ industry.

The web erupted last week after Washington State University issued a news release titled “Researchers see added nutritional benefits in organic milk,” promoting a just-published study as a long awaited silver bullet proof of the superior health benefits of organic foods. All the stories lacked were consensus science. Here’s how the media bungled their reporting and what the science really says—and doesn’t say.

The study, co-authored by well-known organic researcher Charles Benbrook, claimed to be “the first large-scale, U.S.-wide comparison of organic and conventional milk”—it wasn’t, but we’ll get to that later. Published in PLOS ONE, the Public Library’s open-access resource, the news struck immediate media gold, spawning a spate of misleading headlines and stories, even in the mainstream press.

“More Helpful Fatty Acids Found in Organic Milk,” headlined Kenneth Chang’s New York Times story. (Fact: organic milk does not have higher concentrations of more helpful fatty acids.) Businessweek‘s Andy Martin’s report was titled “Is Organic Milk Better for You? It Might Be.” (Fact: It’s not.) The NBC News headline for the story by Melissa Dahl, a health writer and editor, was among the least responsible: “Yep, organic milk really is better for you than regular milk.” (Fact: Nope.)

The activist media upped the ante, with stories that read like industry news releases in Mother Jones (Tom Philpott cites the study as ‘proof’—Fact: No way.) and Grist “Organic milk is better for your heart” (Fact: No better than conventional milk.), and the promotion of the story by the Organic Consumers Association, Stonyfield Organic and other companies and organizations set to gain financially from this news.

While the rapturous headlines and the endorsements sound definitive, the science is anything but. The flurry of uncritical stories touched off by the release of this study is a textbook example of how easily science can be manipulated and misrepresented—and why journalistic vigilance is so critical.

Fatty acid conundrum

Charles Benbrook claims that “organic milk is better” than conventional milk because it contains significantly higher concentrations of heart-healthy fatty acids. Testing nearly 400 samples over an 18-month period, the research team found that conventional milk they tested had an average omega-6 to omega-3 fatty acid ratio of 5.8, more than twice the ratio of 2.3 they reported from organic milk. They say that is a more favorable balance.

Independent scientists—those with no financial ties to the organic industry—say that the Benbrook study is rife with methodological problems and questionable scientific assumptions. Rossi Filippo, a nutritionist with the Institute of Food Science and Nutrition at the Catholic University of the Sacred Heart in Milan, pointed out in an email that the omega-6 to omega-3 ratio should be calculated considering the whole diet, not only with one food. But even if the recalculated ratio should hold, the sweeping conclusions—that organic milk is better for us—is almost certainly wrong.

The problems with the study go far beyond poor math. While some scientists argue that higher ratios of omega-6 to omega-3 lead to greater health risks, that’s not the consensus belief. Dr. Walter Willett, chairman of the nutrition department at the Harvard School of Public Health says that studies like this one that claim that omega-6 fatty acids are harmful promote a “false assumption.” According to Willett, omega-6s are actually associated with a lower risk of heart disease. The ratio touted in the study is “irrelevant,” he says, and health conscious consumers should eat more of both kinds of fatty acids—directly contradicting a central assumption in the Benbrook study.

Other scientists are concerned about the crude way Washington State University and Benbrook promoted the research. They make it seem like a breakthrough study, a  theme echoed widely in news stories, and even by the New York Times in its otherwise balanced report. Kenneth Chang calls it “the most clear-cut instance of an organic food’s offering a nutritional advantage over its conventional counterpart.”

In fact, study after study—thousands of them, with the 237 considered most pertinent summarized in a meta-analysis by a team at Stanford University published last year—have found “little evidence of health benefits from organic foods.” The American Academy of Pediatrics and the Mayo Clinic, among dozens of organizations, have said organic foods offer no nutritional advantages over conventional foods, and the National Dairy Council, which represents organic and conventional farmers, states there are no unique benefits from organic milk.

Despite Benbrook’s claim, this is neither the first major nor the most comprehensive study comparing the health differences of organic and conventional milk. In 2010, for example, the Journal of Dairy Science evaluated samples from 48 states and reached the opposite conclusion from Benbrook’s one-off publication. That study also looked at milk labeled as recombinant bovine somatotropin (rbST) free. (rbST is a synthetic version of the protein, which organic activists, including Benbrook, say is unhealthy, although there is no data to support that claim.) The conclusion in JDS:

Overall, when data from our analysis of [fatty acid] composition of conventional milk and milk labeled rbST-free or organic were combined with previous analytical comparisons of the quality and composition of these retail milk samples, results established that there were no meaningful differences that would affect public health and that all milks were similar in nutritional quality and wholesomeness.

Grass fed not organics

“The problem with this study,” animal scientist at the University of California-Davis Alison Van Eenennaam notes in an email, “is that it conflates ‘organic production’ with ‘omega-3 levels in pasture’. Fatty acids found in milk are derived almost equally from two sources: feed and the microbial activity in the rumen of the cow.  It is well known that milk from cows consuming grass has slightly higher levels of omega-3 fatty acids. Grass-fed conventional milk would have the same fatty acid profile. This can actually be seen in the study. Conventional milk from Northern California, where cows are typically grazing pasture, had a fatty acid profile and omega-3 content similar to organic milk.”

What about the claim that organic farmers are more likely to grass feed their cows? That’s true in some cases but not in others. Depending upon the time of the year organic cows may or may not graze on pasture. According to USDA organic guidelines, they can technically be off it for 8 months if raised in a region with a short grazing season.

“In practice, organic farms as well as conventional farms can vary widely in feeding and diet formulations,” writes Van Eenennaam. “This variation was demonstrated in a 2009 study that compared the omega-3 fatty acids milk fat content from three retail sources of organic and conventional milk, as well as one individual organic farm, every other week for 18 months. The individual organic farm had the highest and the lowest omega-3 fatty acids values, illustrating the substantial variation that exists even within a single farm.”

Bottom line: the fatty acid levels in milk (even if the ratios are meaningful) do not necessarily have anything to do with organic methods. Milk composition is determined by breeding (genetics), the feed cows consume, how the cow is raised, lactation stage and season. In this context, the data in the Benbrook study looks like little more than overhyped noise.

Studies in Britain from several years ago have showed that conventional milk from cows fed on a diet of mostly grass tend to produce this exact result, notes Graham Brookes, an economist with the agricultural consultancy PG Economics. In the UK, most milk is produced this way, so whether it’s organic or not is irrelevant.

It’s not even established that fatty acids from milk—organic or conventional—provide any unique health benefits. Studies demonstrating the benefits of certain fatty acids have focused on fish oils, not on dairy products. After the publication of a similarly flawed 2010 study of organic and conventional milk in England (Mother Jones hawked that study too), the UK Food Standards Agency evaluated and rejected claims by organic milk supporters that their products offered a health benefit, recommending oily fish as the only way to get beneficial omega fatty acids.

Conflicts of interest dog organic study

Only the New York Times, among the major media, provided some counterweight to Benbrook’s hyped claims about the alleged benefits of organic milk even though it fell prey to sensationalist journalism in its title. Times reporter Chang was also one of the few journalists to highlight the clear conflict of interest in the funding of the study. (Call out to Philpott—good reporting on this.) Almost all the research dollars came from Organic Valley, a mega farm cooperative that sells organic products and is positioned to reap a huge financial windfall if the publicity over the study influences consumer buying behavior.

Contrast this deafening silence to what happens whenever research is released that links conventional or genetically modified foods to a health or sustainability benefit—for example, when studies found that Golden Rice enhances nutrition or Bt cotton reduces pesticide use. Journalists’ knives come out, usually in the first sentence (“In a study funded by the biotechnology industry, researchers have found….”). Organic and anti-GMO activists dismiss these studies outright (“Scientists Tied to Tobacco Industry Propaganda, and Funding from Monsanto, Turn Attention to Organic Food,”) claiming the entire conventional food industry is corrupt, and therefore all studies they produce are worthless regardless of the independent controls built in to ensure the credibility of the data.

Then there’s the issue of Charles Benbrook himself. I found no mainstream stories that addressed the organic researcher’s highly politicized role in this debate. Benbrook is a well-known activist who regularly savages conventional agriculture, criticizes crop biotechnology and accepts research money from the organic industry. In short he is a classic industry funded scientist whose research activists should reject outright. As GMWatch has noted, “Conflict of interest consistently obfuscates the claims of safety made by industry affiliated scientists.”

Noting the funding sources of a study helps readers contextualize information; but when it comes to reporting on a favorite subject of health and foodie reporters—organics—journalistic responsibility often goes out the window. If this had been a study funded by the conventional ag industry and it had concluded that organics offered no clear health benefits, anti-GMO and and prominent organic advocacy groups would have ridiculed the study and labeled the author a “shill”.

Benbrook’s research is controversial. He is perhaps best known among scientists for releasing multiple studies, most recently last year, claiming that the cultivation of genetically modified crops leads to increased pesticide use, a popular talking point of anti-GMO activists. As we reported at the Genetic Literacy Project in October 2012, many scientists savaged this claim, saying it appeared he had cooked the data to bolster his anti-GMO campaigning.

“I can’t help but get the feeling that Dr. Benbrook started with a conclusion and found data to fit rather than starting with a general review then finding significant conclusions,” noted Anastasia Bodnar, co-founder of the non-profit Biofortified website. She cited far more extensive research that contradicted his extrapolations—Benbrook did not have hard data for much of his analysis—and pointed out that independent of overall annual volume usage numbers, the toxic profile of pesticides used in conjunction with commodity crops, primarily glyphosate, is far less harmful than the pesticides it replaced and even less harmful than some organic alternatives.

In an apparent eagerness to promote a ‘breakthrough’ study that puts a permanent halo on organic foods, many reporters fell victim to “single study syndrome”—the notion that the latest study no matter how one-off or poorly executed trumps all previously published data and deserves promotion. Compounding that problem, in this case, most reporters just didn’t do their homework, or if they did, they did not grasp the fundamental methodological problems with the study.

There could be serious health consequences from poor reporting about organic milk. Organic foods are expensive and by the judgment of independent scientists are not worth the extra cost if one is looking for health benefits. Plus, they can pose unique dangers. For example, unpasteurized organic milk and cheese have become a fad among ‘health conscious’ consumers entranced by organic industry promotions. Just this week, the American Academy of Pediatrics warned that babies and children are at increased risk from raw and unpasteurized milk and cheese that can carry bacteria such as E. coli and Salmonella from sick animals or contact with manure, which is used as fertilizer on organic farms. Some but not all organic milk is sold as raw or unpasteurized. Organic Valley Coop, which funded the Benbrook study and misrepresents it on links from its website (“Organic Valley’s milk healthier than conventional alternatives”) sells raw cheeses that it brags as being made from “organic cultured unpasteurized milk.”

If reporters had done even a minimal amount of research, they would have come across numeorus studies suggesting that organic milk offers no meaningful advantages and might even pose some health challenges. For example, a 2008 study in the Journal of the American Dietetic Association that analyzed retail samples of conventional, rbST-free and organic milk found that organic milk does show a minimal increase in protein. But conventionally-labeled milk had the lowest bacterial counts (although the differences were not biologically meaningful) of the three varieties and conventional milk had less of the endocrine disrupting chemicals estradiol and progesterone than organic milk.

A 2010 study published in the Journal of Dairy Sciences found that organic milk was higher in saturated fatty acids, considered to be less healthy, and lower in heart-healthier monounsaturated fatty acids when compared to both conventional and rbST-free milk. The differences were measurable but minor, and not significant enough to be considered a health issue—as in the case of Benbrook’s findings, although that’s not what he claims and what many reporters hyped.

So, what did we actually learn from the Benbrook milk study touted by the likes of the New York Times and every organic site known to humankind? Milk from cows that graze on pasture, whether on organic or conventional farms, contain more omega-3 fatty acids that do not provide any unique health benefits. That’s headline material?

Like any research undertaken by a true believer, science is vulnerable to taking a back seat to spin. Hundreds of independent studies by dozens of the top independent science organizations around the world have concluded that organic foods offer no unique health benefits when compared to conventional varieties. Botched reporting just promotes cynicism and contributes to efforts by many in the organic establishment to demonize conventional agriculture and biotechnology. That some journalists participated in what amounts to a marketing blitz for the organic industry is unconscionable.

Jon Entine, executive director of the Genetic Literacy Project, is a senior fellow at the Center for Health & Risk Communication and STATS (Statistical Assessment Service) at George Mason University.

Jeremy Summers is a freelance science writer and editor. Having gotten his start covering North Carolina’s extensive biotechnology industry, he currently contributes to and manages the Genetic Literacy Project website.

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Schizophrenia and lower cognitive ability genetically linked

Researchers at the Feinstein Institute for Medical Research of Northshore LIJ recently discovered evidence of a genetic overlap between schizophrenia and general cognitive ability.

Based on available data from the World Health Organization, approximately 2.2 million people in the US–and up to 24 million persons worldwide–are living with schizophrenia, a chronic, severe and disabling brain disorder. People with schizophrenia have a marked decrease in overall cognitive abilities, and as a result have difficulty with keeping jobs, finishing school, and moving forward in life.

“This research leads us to a deeper understanding of how schizophrenia affects the brain at the molecular level,” said Dr. Lencz. “Our studies are designed to provide clues to the development of new treatments to improve the lives of our patients.”

Read the full, original story: Genetic Overlap Found Between Schizophrenia And Cognitive Ability

Simple genetic modification could restore American chestnut to dominance

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The American chestnut—once a dominant species in the eastern US, now almost completely wiped out by a poisonous fungus—could have another chance at flourishing. Scientists have come up with a simple genetic modification to create a fungus-resistant chestnut, but the question remains—should it be planted in natural forests?

Bernd Heinrich, emeritus professor of biology at the University of Vermont, writes in a New York Times op-ed that he is concerned about the impact of the GM chestnuts on natural forests. Heinrich grows his own American chestnuts in a forest of over 600 acres—and his have a natural resistance to the blight, which could mean they were selected for those traits. But the GM “freaks,” Heinrich writes, could be dangerous, as “genetic engineering can be unpredictable–genes behave and are expressed in complex ways.”

Dr. Barry Starr, geneticist-in-residence at the Tech Museum of Innovation in San Jose, CA, writes that it is “very hard to find a plausible way” that the GM chestnut could have a hazardous effect on the environment. They were not modified to be resistant to a pest or an herbicide, they are simply engineered to fight off a fungus by neutralizing an acid.

The fungus, Cryphonectria parasitica, kills the chestnut tree by poisoning it with oxalic acid. When investigating a way to combat the fungus, scientists at SUNY’s College of Environmental Science and Forestry realized that all they needed to do was find a way to make the tree neutralize the acid. They found a gene in wheat that gives rise to the oxalate oxidase enzyme—which breaks down oxalic acid—and inserted it into the genome of the chestnut.

Strains of the GM tree that make more oxalate oxidase are more resistant to the fungus. When the gene is in the right place in the chestnut’s DNA, it makes a lot of the enzyme to fight off the blight. Scientists have created a GM chestnut that could restore the forests back to what they were a century ago, Starr writes, and field studies look promising. Researchers are hoping to get approval soon for widespread planting of the GM chestnut.

Read the full, original story: Revitalizing Our Forests

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Human family dynamics explained through the lens of bird evolution

Humans often rear their children with help from family and friends. But why would such a strategy evolve? What could we possibly get out of rearing somebody else’s child? Now, scientists believe that they’ve unraveled this mystery — at least when it comes to birds.

Though cooperative breeding is a seemingly odd behavior, studies suggest that it occurs in approximately 9 percent of bird species. In this type of child rearing, three or more birds will contribute to caring for the young in a nest, providing both food and protection.

When a bird decides to become a helper, it loses out on reproducing during that season. But it’s not the case that they’re purposefully giving up reproduction to help — they usually wind up helping because there are no breeding territories left for them.

Read the full, original story: Birds offer insight into the evolution of extended families

Why Whole Foods dropped Chobani yogurt? It’s about corporate profits, not GMOs

Why did the grocery giant Whole Foods drop Chobani Greek-style yogurt?

The reason suggested by the Wall Street Journal: Whole Foods wants to move towards disclosure of all genetically modified ingredients. Chobani uses milk from cows that eat genetically modified corn and soybeans, which Chobani says is the only way it can produce enough yogurt to supply the burgeoning market.

But the New York Times in its analysis makes it clear that the corporate bottom line, not sustainability concerns, is driving this decision. Whole Foods acknowledges it wants to phase out the popular Chobani brand and replace it with a house brand, which would have a far higher profit margin. In other words, it was a hard-edged business decision, not about any concern over GMOs or its customer base.

But the best way for Whole Foods to cash in on that fashionable, high-margin product? Make the stuff itself. That way, it can offer all the custom new options it wants, without sharing profits with a global brand. It’s also easier to control pricing on private label stuff, which Whole Foods is finding increasingly important as it enters more urban areas, and is more profitable to begin with.

Read the full, original story: Why did Whole Foods drop Chobani?

Reporter David Dobbs revises ‘selfish gene’ coverage under fire

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The term “selfish gene” describes sequences of DNA that spread by forming additional copies of itself within the genome and make no specific contribution to the reproductive success of the organism in which it is found. After David Dobbs wrote a critique of the concept earlier this month in Aeon magazine that stoked a firestorm of his own making, the science writer revisited his article, putting the theory and the role of science writing in public discourse under healthy scrutiny.

The notion of the “selfish gene” has been around for more than three decades, since evolutionary biologist Richard Dawkins first coined the term in his 1976 book, The Selfish Gene. For just as long, the idea has been quite controversial, polarizing scientists, researchers and journalists. Dawkins’s book promoted the hotly debated idea that all living things, including humans are ‘motivated’ by their genes and see the metaphor as being outdated in that it doesn’t allow for randomness.

After the publication of Dobbs’s piece provocatively titled, “Die, Selfish Gene, Die,” numerous writers sharply criticized his take on the subject, including writer Jerry Coyne, who argued that the article made several mistakes:

First, he wants to claim that the metaphor of the selfish gene is wrong. Second, he wants to show that it’s wrong because new understanding of gene regulation—how genes turn on and off during development—render the selfish gene metaphor passé. Finally, he claims that a new theory, that of “genetic accommodation,” relegates much of conventional evolutionary theory to the dustbin, for the new theory deposes the centrality of the gene in favor of the centrality of the environment and its non-genetic effects on development.

Blogger Sergio Graziosi, a former molecular neurobiologist, called it “well written” and “well documented” but wrong.

Claiming that we need new evolutionary concepts to replace the faulty idea of the selfish gene is just downright wrong. What we do need to understand and model in new and more reliable ways is how a genome entirely made up of selfish genes (and other selfish non-coding sequences) can evolve to create monstrously complex networks that allow the astonishing adaptability of human bodies. The challenge is to see how, why and when “selfish”* elements associate and “collaborate” in ever more complex ways (generating the variability that is impossible to pin down to a single gene).

Facing many similar rebukes, Dobbs revised and significantly expanded his article and posted a blog entry explaining his reason for doing so. As Dobbs explained, he modified his original article based on the “public conversation” his article article stirred:

I am not saying that the all the science described or suggested by the ‘selfish gene’ model is wrong. I am observing that while the selfish gene story is adept at taking in new findings and ideas from genomic studies, anthropology, and other evolutionary studies, it does so these days with increasing discomfort to both host and guest. And I am asking, in an age when such new ideas and disciplines are flourishing and new tools are revealing astounding new things about the genome, whether the selfish gene story remains the best way to account for or inspire them.

Graziosi praised Dobbs’s willingness to revisit his work in the wake of the criticism, but still contested much of the science writer’s take on the subject.

I was wrong in my evaluation of Dobbs’ intentions. He just gave me a lesson on journalistic integrity, leaving a clear and open trace of what he did, why and how, while enriching his content significantly. That’s an example that all science journalists should follow, bravo!

In his post and in a comment sent to the GLP following the original posting of this story, Graziosi provided more context to the ‘selfish gene’ theory and amplifies his concerns about the concept is often mis-characterized:

The selfish gene metaphor emphasises that selection acts on unique sequences of DNA that can be replicated as a unit (genes). Whenever the effects of a particular DNA sequence favour its propagation (replication within the same cell, the same organism/genome and across generations), the sequence will tend to become more frequent. This creates an environment where each gene’s propensity to get copied competes with the same propensity of other genes. The key point is that it is mathematically possible to explain how this basic “selfish replication drive” may generate the whole diversity of life on earth. The theory does include “just selfish” genes that spread without providing any advantage to their host (as you say) but also predicts that (explains why) genes have “an interest” in the welfare of their host: “helping” their host will increase their own chances to get passed on to subsequent generations. From this basic concept it is possible to build models that show how genes will evolve to produce cooperative networks of genes as well as cooperative behaviours between individuals. The “selfish gene ” is a simple explanation of how the complexity of life has evolved, it is *not* challenged by such complexity. The more complex mechanisms are found, the more it becomes relevant, not the other way round.

Dobbs’s original article, the criticism it provoked and his willingness to revise it show an important and necessary aspect of writing about and researching science. Although the debate over the selfish gene won’t end anytime soon, the debate hat it stimulated underscores how important public discourse and intellectual flexibility are when it comes to addressing complex and evolving science.

Read the full, original article: “Die, Selfish Gene, Die” Has Evolved

Read the revised, expanded article: “Die, Selfish Gene, Die” Has Evolved

Read the full, original blog post: “Die, Selfish Gene, Die” Has Evolved

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Bioethical questions arise from advances in neuroscience

brain study bioethics x

Last week, the U.S. Presidential Commission for the Study of Bioethical Issues met to discuss the moral implications of brain science. The meeting was at the request of President Barack Obama, who earlier this year called for the start of a $100 million federal Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative.

The panel was charged with coming up with potential moral and ethical dilemmas that might arise from recent advances in our understanding of the brain and the potential ability to peer into the workings of the human mind promised by his brain-mapping proposal.

As these ethical issues continue to garner media attention, National Geographic asked Hank Greely, a bioethics and genetics expert at Stanford University’s Law School, what he sees as being the five big questions in neuroscience. Greely suggests that using neuroscience to predict peoples’ fate or actions, as a lie detector and in medical care challenges how we view ourselves and will raise many ethical questions.

Read the full, original story: Q&A: The 5 Big Questions in Brain Science

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