In the silk business, sex is money. Male silkworms weave cocoons with more silk of a higher quality than females do, and the multibillion dollar sericulture industry has long sought an easy way to breed only males. That might now be a realistic goal, as researchers have identified the process that determines sex in the silkworm Bombyx mori1. The sex factor is found to be a small RNA molecule — the first time that anything other than a protein has been implicated in a sex-detemination process.
In nearly all Lepidoptera — the order that includes moths and butterflies — sex is determined by a WZ chromosome system, in contrast to the XY system used in mammals. Female silkworms carry W and Z sex chromosomes, whereas males boast a pair of Z chromosomes.
But efforts to identify the genes on the W chromosome that make silkworms female have come up short… Susumu Katsuma and his team report in Nature today that one such molecule, which the authors called Fem, is specific to female silkworms, suggesting that it has a role in sex determination. The Fem RNA breaks down a corresponding molecule made by a gene known as Masculinizer, which is found on the Z chromosome. When the researchers silenced Masculinizer, embryos execute a genetic programme that makes female tissue.
Read the full, original story: Silkworm sex factor is no ordinary gene
