How evolutionary theory may complicate CRISPR as cancer fighting tool

Screen Shot at AM

Using guide RNAs, CRISPR-Cas9 can target and inactivate any gene in a living cell. That makes a powerful tool for loss-of-function analyses of particular genes’ roles in disease.

But CRISPR-Cas9’s promise becomes less certain when it comes to cancers, [Ewald] cautioned.

[In addition, o]ne concern is the fact that genes are frequently pleiotropic, affecting multiple molecular pathways. Just because a gene promotes tumor growth does not imply that it lacks other, beneficial effects.

[“]But the problem is that if you’re putting a gene into an organism that has undergone evolutionary selection pressures that have adjusted all of a gene’s pleiotropic effects, then you affect those, too,” Ewald cautioned.

It is open to question, however, whether the next big genome-editing breakthrough will come from systemically screening natural CRISPR and CRISPR-like systems.

“It is certainly hard to predict whether new gene editing systems will emerge from very broad studies of natural CRISPR systems,” Dr. [Dana] Carroll said. “I’m sure additional variants will turn up, but perhaps nothing dramatically different from what we’ve seen already.”

The GLP aggregated and excerpted this blog/article to reflect the diversity of news, opinion and analysis. Read full, original post: The Evolutionary Implications of CRISPR-Cas9 for Clinical Oncology

Outbreak
Outbreak Daily Digest
Biotech Facts & Fallacies
Talking Biotech
Genetics Unzipped
Video: Test everyone – Slovakia goes its own way to control COVID

Video: Test everyone – Slovakia goes its own way to control COVID

As Europe sees record coronavirus cases and deaths, Slovakia is testing its entire adult population. WSJ's Drew Hinshaw explains how ...
mag insects image superjumbo v

Disaster interrupted: Which farming system better preserves insect populations: Organic or conventional?

A three-year run of fragmentary Armageddon-like studies had primed the journalism pumps and settled the media framing about the future ...
dead bee desolate city

Are we facing an ‘Insect Apocalypse’ caused by ‘intensive, industrial’ farming and agricultural chemicals? The media say yes; Science says ‘no’

The media call it the “Insect Apocalypse”. In the past three years, the phrase has become an accepted truth of ...
globalmethanebudget globalcarbonproject cropped x

Infographic: Cows cause climate change? Agriculture scientist says ‘belching bovines’ get too much blame

A recent interview by Caroline Stocks, a UK journalist who writes about food, agriculture and the environment, of air quality ...
organic hillside sweet corn x

Organic v conventional using GMOs: Which is the more sustainable farming?

Many consumers spend more for organic food to avoid genetically modified products in part because they believe that “industrial agriculture” ...
benjamin franklin x

Are most GMO safety studies funded by industry?

The assertion that biotech companies do the research and the government just signs off on it is false ...
favicon

Environmental Working Group: EWG challenges safety of GMOs, food pesticide residues

Known by some as the "Environmental Worrying Group," EWG lobbies for tighter GMO legislation and famously puts out annual "dirty dozen" list of fruits and ...
m hansen

Michael Hansen: Architect of Consumers Union ongoing anti-GMO campaign

Michael K. Hansen (born 1956) is thought by critics to be the prime mover behind the ongoing campaign against agricultural biotechnology at Consumer Reports. He is an ...
News on human & agricultural genetics and biotechnology delivered to your inbox.
Optional. Mail on special occasions.
Send this to a friend