How epigenetics, our gut microbiome and the environment interact to change our lives

| October 17, 2016
Screen Shot at PM
This article or excerpt is included in the GLP’s daily curated selection of ideologically diverse news, opinion and analysis of biotechnology innovation.

There’s been increasing media coverage recently harkening back to Lamarck and inheritance of genetic code that changes in response to the environment (epigenetics).

”Lamarckism” as it came to be called was eschewed for more than a hundred years after its initial proposition because it was thought that genes were static (this reminds me of how Einstein originally developed a model which required an expanding universe, then he added a coefficient (the ‘Cosmological Constant’) to return its behavior to a static state, which later in hindsight was found to be wrong). Now it appears Lamarck while overstating the plasticity of genes, was on to something.

Epigenetics suggests that our genes are constantly in a state of flux, exposed and changing in response to environmental factors. But are these changes indeed heritable? Currently, there isn’t yet consensus that environment, epigenetics, and inheritance intersect or a valid theory for how genes behave in organisms. But now that Lamarckism is back in the public’s vernacular there will be countless studies performed to support or refute the thesis.

Screen Shot 2014-04-15 at 10.33.54 AMResearch presented at the American Association for the Advancement of Science 2014 conference supported some conjecture that epigenetics and some form of heritability are in fact linked. That suggests that much of our lives and life trajectories could, in fact, reflect a sensitive interplay between our environment, genes (epigenetics) and microbiome, as in illustrated in the Venn diagram, in which the intersection of all of these factors is, quite simply, ‘us.’

The proposed Venn of the interplay of our environment, adaptable genes, and microbiome. At the center intersection: Us.

External environment

We are influenced by external factors (sunlight, environmental toxins, stress, temperature, etc.), all of which can, to varying degrees, alter our genes. I’ve already explained in another article how something as simple as grapefruit can downregulate (inhibit the activity of) enzymes produced by our genes, making it more likely that the external environment will interact with our body; grapefruits interact with more than 90 drugs because of this effect. It’s also been shown that the ultraviolet part of the spectrum in sunlight causes physical changes in cellular DNA, which can lead to skin cancer.DNA_UV_damage

We also know of chemicals and drugs that have teratogenic (can disturb the development of an embryo or fetus) properties. A Lancet study from 2012 showed that 510,000 deaths occurred worldwide as a result of congenital disorders. Therefore, we know of many external mechanisms and their impact on our body, potentially through epigenetic means. The penultimate forerunner of epigenetics is the Hygiene Hypothesis, which states that a lack of early exposure to foreign bodies (bacteria, viruses, parasites, allergens, etc.) is associated with a dysregulated (i.e., not functioning normally) immune system.

Microbiome

News coverage has flirted with the topic of digestive microbiome (euphemistically called ‘gut health’ or similar). What I read is often misquoted from the research literature, ‘extrapolated’ and generalized beyond the study data and littered with anecdotes. What IS clear is that we are, on average, too clean.post-2282-Human-Microbiome-Project-Decod-YCSc

The microbiome usually refers to the flora that colonizes our digestive systems. I specifically didn’t refer to this (logically enough) as the ‘internal environment.’ Why? Here’s the reality to our ‘internal’ and ‘external’ environments: The human body has developed in such a way that the alimentary canal (digestive system) forms a path through the body. In this way, the body basically envelops the space that is the alimentary system; therefore your digestive system is outside of your body. Let’s think about that again: Inside your digestive system is outside of your body. Your body accesses nutrients through digestion from food passing through, but these nutrients pass through your intestinal walls, and your body is separated from the food by many layers of cellular lamina; the food is outside of your body. By contrast, those things inside of your body, such as organs, blood, etc. are designed to be axenic – this term means ‘free from foreign bodies.’ If you weren’t axenic, that would mean that you had an active infection.

A significant portion of this is the microbiome of the gut. There is an incredible, largely invisible world, of cellular communication, symbiosis and chemistry occurring between ‘us’ and our microbiome. Strictly speaking, we could consider these organisms to be ‘outside’ of our body, based on what I described earlier. But either way make no mistake: Without our intestinal flora, we would not survive. They are part (a large part) of our immune system, they help digest food, they keep us free from illness by out-competing foreign pathogens (by producing bacteriocins, fatty acids, and clocking prevent pathogen implantation).

Our intestinal colonies have also been targeted for study because of how they make antioxidants in cocoa available for our bodies to use. A meta-analysis (a study of studies) of 20 research papers showed a meaningful drop in blood pressure in those who consumed dark chocolate or cocoa daily; this is a direct result of the fermentation and further digestion of these compounds made possible by our microbiome.

How Do These Three Pieces Interact?

As shown in the Venn diagram, there is a circularity here. Each of the elements influences the other: Our environment provides the stimulus for epigenetics; our microbiome influences epigenetics; our environment affects our microbiome.

Some novel research indicates that certain compounds produced by certain gut flora can make colon cancer more prevalent by blocking the activity of DNA repair proteins. And that may not be just something for ‘someone else’ to worry about; another recent finding published in Nature shows that the composition of the gut microflora can be changed very ‘rapidly and reproducibly’ in response to dietary changes. Some of the consequences are directly due to microbial gene expression. This could be for the worse, but could of course also be for the better (reducing the odds of genetic changes and cancer).

Even the inflammatory cascade of Crohn’s disease seems to be related to the gut microbiome and specific microbes in particular. The researchers in this particular study even developed a model called a “microbial dysbiosis index” to predict Crohn’s disease onset and severity based on the flora present in study participants.

Fairly robust evidence exists to suggest that children raised in more rural areas (more exposure to animals, dirt, debris, molds, pollen, etc.) suffer from fewer cases of allergies than those children raised in more urban settings. Again, that pattern suggests an interplay of our external environment, microbiome, and epigenetics.

Ben Locwin, Ph.D., MBA, M.S. is a contributor to the Genetic Literacy Project and is an author of a wide variety of scientific articles for books and magazines. He is also a neuroscience researcher and consultant for many industries including food and nutrition, pharmaceutical, psychological, and academic. Follow him at @BenLocwin.

The GLP featured this article to reflect the diversity of news, opinion and analysis. The viewpoint is the author’s own. The GLP’s goal is to stimulate constructive discourse on challenging science issues.

Outbreak
Outbreak Daily Digest
Biotech Facts & Fallacies
Talking Biotech
Genetics Unzipped
a a b b a f ac a

Video: Death by COVID: The projected grim toll in historical context

The latest statistics, as of July 10, show COVID-19-related deaths in U.S. are just under 1,000 per day nationally, which is ...
mag insects image superjumbo v

Disaster interrupted: Which farming system better preserves insect populations: Organic or conventional?

A three-year run of fragmentary Armageddon-like studies had primed the journalism pumps and settled the media framing about the future ...
dead bee desolate city

Are we facing an ‘Insect Apocalypse’ caused by ‘intensive, industrial’ farming and agricultural chemicals? The media say yes; Science says ‘no’

The media call it the “Insect Apocalypse”. In the past three years, the phrase has become an accepted truth of ...
types of oak trees

Infographic: Power of evolution? How oak trees came to dominate North American forests

Over the course of some 56 million years, oaks, which all belong to the genus Quercus, evolved from a single undifferentiated ...
biotechnology worker x

Can GMOs rescue threatened plants and crops?

Some scientists and ecologists argue that humans are in the midst of an "extinction crisis" — the sixth wave of ...
food globe x

Are GMOs necessary to feed the world?

Experts estimate that agricultural production needs to roughly double in the coming decades. How can that be achieved? ...
eating gmo corn on the cob x

Are GMOs safe?

In 2015, 15 scientists and activists issued a statement, "No Scientific consensus on GMO safety," in the journal Environmental Sciences ...
Screen Shot at PM

Charles Benbrook: Agricultural economist and consultant for the organic industry and anti-biotechnology advocacy groups

Independent scientists rip Benbrook's co-authored commentary in New England Journal calling for reassessment of dangers of all GMO crops and herbicides ...
Screen Shot at PM

ETC Group: ‘Extreme’ biotechnology critic campaigns against synthetic biology and other forms of ‘extreme genetic engineering’

The ETC Group is an international environmental non-governmental organization (NGO) based in Canada whose stated purpose is to monitor "the impact of emerging technologies and ...
Share via
News on human & agricultural genetics and biotechnology delivered to your inbox.
Optional. Mail on special occasions.
Send this to a friend