‘Cancer vaccine’ shows promise in mice; human trial next


A combination of a tiny segment of DNA and a specific antibody injected into a solid tumour has been shown to remove not only the target tumour, but also others in the body, at least in mice.

Like several other treatments, the combination therapy, reported in the journal Science Translational Medicine, prompts the body’s own immune system to tackle tumours. However, unlike others, it functions as a one-size-fits-all strategy. To a significant extent, it seems, it is not necessary to first identify the type of cancer involved.

The Stanford team’s strategy works by exploiting the curiously ambivalent relationship between cancer tumours and immune cells called T cells. The latter function to attack bodily invaders through detecting abnormal proteins. Initially the T cells will recognise such proteins on the surface of cancer cells and enter the developing tumour. However, as the tumour continues to grow, T cell activity drops off. In a sense, the immune system gives up. [Researcher Ronald] Levy and his colleagues found a way to reactivate the moribund T cells.

The first trial involved 90 animals with lymphoma tumours on both sides of their bodies. In each, only one tumour was treated. The paper details that 87 out of the 90 were cured.

An initial human trial will get underway soon, with the researchers looking to recruit about 15 patients with low-grade lymphoma.

Read full, original post: Cancer “vaccine” makes tumours vanish

Outbreak Daily Digest
Biotech Facts & Fallacies
Talking Biotech
Genetics Unzipped

Video: We can ‘finally’ grow GMOs—Nigerian farmer explains why developing countries need biotech crops

Nigerian farmer Patience Koku discusses the GMO crop trials she is conducting on her farm, and why growers can "rise ...
mag insects image superjumbo v

Disaster interrupted: Which farming system better preserves insect populations: Organic or conventional?

A three-year run of fragmentary Armageddon-like studies had primed the journalism pumps and settled the media framing about the future ...
dead bee desolate city

Are we facing an ‘Insect Apocalypse’ caused by ‘intensive, industrial’ farming and agricultural chemicals? The media say yes; Science says ‘no’

The media call it the “Insect Apocalypse”. In the past three years, the phrase has become an accepted truth of ...
breastfeeding bed x facebook x

Infographic: We know breastfeeding helps children. Now we know it helps mothers too

When a woman becomes pregnant, her risk of type 2 diabetes increases for the rest of her life, perhaps because ...
organic hillside sweet corn x

Organic v conventional using GMOs: Which is the more sustainable farming?

Many consumers spend more for organic food to avoid genetically modified products in part because they believe that “industrial agriculture” ...
benjamin franklin x

Are most GMO safety studies funded by industry?

The assertion that biotech companies do the research and the government just signs off on it is false ...
gmo corn field x

Do GMO Bt (insect-resistant) crops pose a threat to human health or the environment?

Bt is a bacterium found organically in the soil. It is extremely effective in repelling or killing target insects but ...

Environmental Working Group: EWG challenges safety of GMOs, food pesticide residues

Known by some as the "Environmental Worrying Group," EWG lobbies for tighter GMO legislation and famously puts out annual "dirty dozen" list of fruits and ...
m hansen

Michael Hansen: Architect of Consumers Union ongoing anti-GMO campaign

Michael K. Hansen (born 1956) is thought by critics to be the prime mover behind the ongoing campaign against agricultural biotechnology at Consumer Reports. He is an ...
News on human & agricultural genetics and biotechnology delivered to your inbox.
Optional. Mail on special occasions.
Send this to a friend