Viewpoint: Gene editing poised to revolutionize agriculture—if we can fix biotech regulations

d db a a c d aabb sized x

In his speech at the recent American Farm Bureau convention, President Trump said his administration was “streamlining regulations that have blocked cutting-edge biotechnology.”

Why is this necessary?  Paraphrasing New York Times columnist Paul Krugman’s words on economic policy, it’s because we’re still living with “zombie” biotech regulatory policies that “should have been killed by the evidence … but keep shambling along nonetheless.” The time to end this “reign of error” is now.

Why now? Because the evidence is in: Biotechnology methods are safe. And because new, precise gene-editing approaches are poised to revolutionize agriculture.  But for that to happen, we have to start regulating from common sense instead of fear.

For the past 30 years, every organism improved using modern biotechnology methods, no matter how innocuous, has been regulated as if it were potentially hazardous. The price of compliance with such fear-based regulation has been huge – more than $100 million for a single biotech crop. And it can take years to obtain regulatory approval.

Nina Fedoroff
Nina Fedoroff

The result? We have no agricultural animals improved using biotechnology on the market and we have just a handful of commercial biotech crops.  Most are commodity crops with big enough markets to allow recovery of hundred million dollar expenditures on development and deregulation. Is it any surprise that they were developed by big companies with deep pockets? Few small companies or academic scientists have been able to get into the game.

American farmers were quick to adopt biotech crops. They’ve been growing biotech corn, soybeans and cotton for more than 20 years. Trillions of meals with biotech ingredients have been consumed with no ill effects. Biotech crops have added billions to our national wealth and made farming kinder to the environment.

And yet we’re still regulating as if biotech methods were dangerous. Today, scientists around the world are overwhelmingly convinced by the evidence that biotech methods are safe. Biotech approaches are much less disruptive to the genetic machinery than the chemical and radiation mutagenesis used for crop improvement – with no regulation at all – for most of the last century.  And they’re much more exact than cross-breeding.

New gene-editing tools are even more precise than the older methods. They can be used to make predictable changes in a selected gene and leave behind no extraneous genetic material.  Such changes are just like the natural variants that underlie the domestication of agricultural plants and animals. And they’re the same as genetic changes introduced by the mutagenic methods used to produce most of today’s high-yielding grain varieties and such favorites as Rio Red grapefruit.

Related article:  Viewpoint: Intensive agriculture is the only way to sustainably feed the world

This means that many of the organisms produced using today’s high-precision gene editing will be indistinguishable at the molecular level from those produced by nature and by previous generations of breeders. This presents a conundrum for our current regulatory approach.

Alison Van Eenennaam
Alison Van Eenennaam

Fortunately, the solution is in plain sight: Confine regulatory scrutiny to the novel properties of improved organisms. That is, regulate the product, not the process, as the U.S. National Academies of Science and Engineering have long recommended.

Regulators must identify the (handful of) novel properties of improved organisms that present unreasonable risks to people, animals, agriculture or the environment and they must restrict regulatory scrutiny to such organisms.

The rest present hazards no different from those posed by plants and animals improved by long familiar plant breeding techniques and require no regulation.  To move quickly in a highly competitive international environment, developers need the certainty that they will not face burdensome bureaucratic barriers if they use gene editing to develop products whose properties are no different from those that can be derived by conventional breeding methods. Australia has already begun to move in this direction.

Dispelling the suffocating cloud of fear-based biotechnology regulation is a must if the U.S. is to maintain global leadership in biotechnology. Bringing common sense to regulation by recognizing that modern biotech methods are just the next step in our 10,000-year history of agricultural innovation will unleash investment in small biotech start-ups, a heavy lift today because of the regulatory costs. And perhaps most important, it will free agricultural scientists to use the very best biological methods to do their critical work of helping farmers and ranchers provide us with healthful, sustainably grown food.

Nina Fedoroff is a molecular biologist and professor emeritus at Penn State University. She was awarded the National Medal of Science in 2007 and served as president of the American Association for the Advancement of Science (AAAS) from 2011 to 2012. She also served as a science adviser to the Secretary of State and to the administrator of USAID. 

Alison Van Eenennaam, Ph.D. is an animal geneticist and Cooperative Extension specialist in the Department of Animal Science at the University of California, Davis. Follow her on Twitter @BioBeef

Outbreak Daily Digest
Biotech Facts & Fallacies
Talking Biotech
Genetics Unzipped
Video: Test everyone – Slovakia goes its own way to control COVID

Video: Test everyone – Slovakia goes its own way to control COVID

As Europe sees record coronavirus cases and deaths, Slovakia is testing its entire adult population. WSJ's Drew Hinshaw explains how ...
mag insects image superjumbo v

Disaster interrupted: Which farming system better preserves insect populations: Organic or conventional?

A three-year run of fragmentary Armageddon-like studies had primed the journalism pumps and settled the media framing about the future ...
dead bee desolate city

Are we facing an ‘Insect Apocalypse’ caused by ‘intensive, industrial’ farming and agricultural chemicals? The media say yes; Science says ‘no’

The media call it the “Insect Apocalypse”. In the past three years, the phrase has become an accepted truth of ...
globalmethanebudget globalcarbonproject cropped x

Infographic: Cows cause climate change? Agriculture scientist says ‘belching bovines’ get too much blame

A recent interview by Caroline Stocks, a UK journalist who writes about food, agriculture and the environment, of air quality ...
organic hillside sweet corn x

Organic v conventional using GMOs: Which is the more sustainable farming?

Many consumers spend more for organic food to avoid genetically modified products in part because they believe that “industrial agriculture” ...
benjamin franklin x

Are most GMO safety studies funded by industry?

The assertion that biotech companies do the research and the government just signs off on it is false ...

Environmental Working Group: EWG challenges safety of GMOs, food pesticide residues

Known by some as the "Environmental Worrying Group," EWG lobbies for tighter GMO legislation and famously puts out annual "dirty dozen" list of fruits and ...
m hansen

Michael Hansen: Architect of Consumers Union ongoing anti-GMO campaign

Michael K. Hansen (born 1956) is thought by critics to be the prime mover behind the ongoing campaign against agricultural biotechnology at Consumer Reports. He is an ...
News on human & agricultural genetics and biotechnology delivered to your inbox.
Optional. Mail on special occasions.
Send this to a friend