‘More versatile and less error prone’ SATI gene editing could eventually replace CRISPR

image axd

[S]cientists at the Salk Institute have developed a potential game changer in this field – a new gene editor called SATI (intercellular linearized Single homology Arm donor mediated intron-Targeting Integration).

SATI is itself an advance on a new form of gene engineering also developed at Salk, called homology-independent targeted integration (HITI) which can introduce new genes into the DNA without having to cut out the old one. The technique uses an alternate DNA repair pathway to integrate the new DNA.

SATI uses either of two different types of DNA repair mechanisms to integrate an inserted DNA segment into the genome. This makes it much more versatile and less error-prone.

Related article:  Plant breeders will move CRISPR gene-editing programs out of EU without updated regulations, industry group says

It can be used to fix different types of mutations, whether they involve the removal, replacement or addition of a part of the DNA strand, in a diverse spectrum of cells, in both dividing and non-dividing states.

Moreover, its target is the noncoding part of the DNA and thus it minimizes the possibility of introducing unwanted changes in the genome. Scientists hope to eventually use SATI to prevent genetic conditions like the neurologic disease called Huntington’s chorea which causes progressive paralysis and death, among others.

Read full, original post: SATI gene editing could replace CRISPR

Outbreak Daily Digest
Biotech Facts & Fallacies
Talking Biotech
Genetics Unzipped
can you boost your immune system to prevent coronavirus spread x

Video: How to boost your immune system to guard against COVID and other illnesses

Scientists have recently developed ways to measure your immune age. Fortunately, it turns out your immune age can go down ...
mag insects image superjumbo v

Disaster interrupted: Which farming system better preserves insect populations: Organic or conventional?

A three-year run of fragmentary Armageddon-like studies had primed the journalism pumps and settled the media framing about the future ...
dead bee desolate city

Are we facing an ‘Insect Apocalypse’ caused by ‘intensive, industrial’ farming and agricultural chemicals? The media say yes; Science says ‘no’

The media call it the “Insect Apocalypse”. In the past three years, the phrase has become an accepted truth of ...
globalmethanebudget globalcarbonproject cropped x

Infographic: Cows cause climate change? Agriculture scientist says ‘belching bovines’ get too much blame

A recent interview by Caroline Stocks, a UK journalist who writes about food, agriculture and the environment, of air quality ...
organic hillside sweet corn x

Organic v conventional using GMOs: Which is the more sustainable farming?

Many consumers spend more for organic food to avoid genetically modified products in part because they believe that “industrial agriculture” ...
benjamin franklin x

Are most GMO safety studies funded by industry?

The assertion that biotech companies do the research and the government just signs off on it is false ...
gmo corn field x

Do GMO Bt (insect-resistant) crops pose a threat to human health or the environment?

Bt is a bacterium found organically in the soil. It is extremely effective in repelling or killing target insects but ...

Environmental Working Group: EWG challenges safety of GMOs, food pesticide residues

Known by some as the "Environmental Worrying Group," EWG lobbies for tighter GMO legislation and famously puts out annual "dirty dozen" list of fruits and ...
m hansen

Michael Hansen: Architect of Consumers Union ongoing anti-GMO campaign

Michael K. Hansen (born 1956) is thought by critics to be the prime mover behind the ongoing campaign against agricultural biotechnology at Consumer Reports. He is an ...
News on human & agricultural genetics and biotechnology delivered to your inbox.
Optional. Mail on special occasions.
Send this to a friend