Bioprinting: Creating pinhead replicas of human organs to fight COVID-19 and other ailments

d bioprinting of organs ella maru studio science photo library
Credit: Science Photo Library

Anthony Atala, the director of the Wake Forest Institute for Regenerative Medicine, and his team are… creating tiny replicas of human organs — some as small as a pinhead — to test drugs to fight Covid-19.

The team is constructing miniature lungs and colons — two organs particularly affected by the coronavirus — then sending them overnight by courier for testing at a biosafety lab at George Mason University in Fairfax, Va.

Dr. Atala says that the organoids allow researchers to analyze a drug’s impact on an organ “without the noise” of an individual’s metabolism.

ADVERTISEMENT

He cited Rezulin, a popular diabetes drug recalled in 2000 after there was evidence of liver failure. His lab tested an archived version of the drug, and Dr. Atala said that within two weeks, the liver toxicity became apparent. What accounts for the difference? An organoid replicates an organ in its purest form and offers data points that might not occur in clinical trials, he said, adding that the testing is additive to, rather than in lieu of, clinical trials.

Related article:  Can we eradicate malaria with promising new gene drive technique?
Follow the latest news and policy debates on agricultural biotech and biomedicine? Subscribe to our newsletter.

The team at Wake Forest is partnering with the technology company Oracle to capture the data from the organoids and analyze it with artificial intelligence. The project, known generally as the body-on-a-chip system, involves printing living tissue on a microchip to allow drugs to be studied for toxicity and efficacy even before clinical trials begin.

Read the original post

Outbreak Daily Digest
Biotech Facts & Fallacies
GLP Podcasts
Infographic: Here’s where GM crops are grown around the world today

Infographic: Here’s where GM crops are grown around the world today

Do you know where biotech crops are grown in the world? This updated ISAAA infographics show where biotech crops were ...
News on human & agricultural genetics and biotechnology delivered to your inbox.
glp menu logo outlined

Newsletter Subscription

* indicates required
Email Lists
Send this to a friend