What’s your biological age? There’s a genetic clock that could tell you

Credit: Society6
Credit: Society6

Biological age isn’t as simple as counting the number of birthday candles you’ve blown out like your chronological age. Rather, it is a measurement of your age based on different biomarkers. Our cells can progress more or less rapidly than our chronological age. Now, researchers at the University of Cologne have developed an “aging clock” that reads the biological age of an organism directly from its gene expression, the transcriptome.

Typically aging clocks have been based on the pattern of methylations. The new clock, however, takes into consideration the set of genes that are read from DNA to make proteins for the cell.

“Aging clocks based on transcriptomes have suffered from considerable variation in the data and relatively low accuracy. Here, we devised an approach that uses temporal scaling and binarization of C. elegans transcriptomes to define a gene set that predicts biological age with an accuracy that is close to the theoretical limit. Our model accurately predicts the longevity effects of diverse strains, treatments, and conditions.”


Follow the latest news and policy debates on agricultural biotech and biomedicine? Subscribe to our newsletter.

The researchers were able to show that the model accurately predicts the effects of several lifespan‐affecting factors such as insulin‐like signaling, a dysregulated miRNA regulation, the effect of an epigenetic mark, translational efficiency, dietary restriction, heat stress, pathogen exposure, and the diet‐ and dosage‐dependent effects of drugs.

Read the original post

Related article:  Gene therapy offers hope for untreatable CTE brain disorder
Outbreak Daily Digest
Biotech Facts & Fallacies
Genetics Unzipped
Infographic: Deaths from COVID-19 are far higher than reported estimates

Infographic: Deaths from COVID-19 are far higher than reported estimates

More than 2.8 million people have lost their lives due to the pandemic, according to a Wall Street Journal analysis ...

Gilles-Éric Séralini: Activist professor and face of anti-GMO industry

The French biologist and his research team--funded by the Rodale ...
vandana shiva

Vandana Shiva: ‘Rock Star’ of GMO protest movement has anti-science history

In a 2012 interview, Bill Moyers referred to Vandana Shiva as ...
News on human & agricultural genetics and biotechnology delivered to your inbox.
glp menu logo outlined

Newsletter Subscription

Optional. Mail on special occasions.
Send this to a friend