There’s no safe way to get a close-up view of the human heart as it goes about its work: you can’t just pop it out, take a look, then slot it back in. Scientists have tried different ways to get around this fundamental problem.
Now, an interdisciplinary team of engineers, biologists, and geneticists has developed a new way of studying the heart: they’ve built a miniature replica of a heart chamber from a combination of nanoengineered parts and human heart tissue. There are no springs or external power sources—like the real thing, it just beats by itself, driven by the live heart tissue grown from stem cells. The device could give researchers a more accurate view of how the organ works, allowing them to track how the heart grows in the embryo, study the impact of disease, and test the potential effectiveness and side effects of new treatments—all at zero risk to patients and without leaving a lab.
The Boston University–led team behind the gadget—nicknamed miniPUMP, and officially known as the cardiac miniaturized Precision-enabled Unidirectional Microfluidic Pump—says the technology could also pave the way for building lab-based versions of other organs, from lungs to kidneys. Their findings have been published in Science Advances.
