What’s the difference between GMO and CRISPR

crispr-gmo-greens-2-1686931309578_1400x.png

What is a GMO?

GMOs (genetically modified organisms) involve transferring a gene from one species to another to provide an organism with a new trait – like pest resistance or drought tolerance. GMOs are also referred to as “transgenic,” for transfer of genes.

Bt corn is an example of a GMO crop that helps reduce pesticide use against the European Corn Borer, a pesky caterpillar that eats the crop. Genes from a naturally occurring soil bacterium, Bacillus thuringiensis, are inserted into corn leaves. Bacillus thuringiensis produces proteins with insecticidal properties that specifically target the European Corn Borer. When the worm starts munching on the corn leaves, it ingests the soil bacterium and dies. The plants produce the toxins in their tissues and there is no need to spray synthetic pesticides or apply Bt mixtures topically.

GMOs involve transferring a gene from one species to another to endow an organism with a new trait – like pest resistance or drought tolerance.

What is CRISPR?

CRISPR is a very precise way of altering or deleting DNA from the same species to obtain the desired outcome. CRISPR allows scientists to shorten the natural evolution of plants by years.

Drought resistant corn, for example, is CRISPR engineered and will enable corn to grow and thrive with limited water. As the climate changes and water becomes scarcer, this will be very important to this major world crop. Another example is the non-browning mushroom, where the gene responsible for browning is silenced. The mushroom enjoys a longer shelf life and there is less food waste.


CRISPR involves editing a gene within the same species to achieve the desired outcome.

Gene-edited crops have the potential to make plants that are higher yielding, drought tolerant, disease resistant, more nutritious, or just better tasting.

CRISPR technology can also be applied to human and animal health and welfare. Scientists are working on cures for Type I DiabetesAlzheimer’s and other human diseases using CRISPR technology. With regard to animals, dairy cows can be saved the pain of manual horn extraction (disbudding) by introducing genetics from Angus cows, which are born without horns.

Both GMO and CRISPR technologies have the potential to provide healthier, more nutritious food, and allow farmers to grow crops with fewer agricultural chemicals and less water.  Additionally, CRISPR is emerging as a promising tool not only for plants and animals but also for human health.

The Bottom Line:

GMO and CRISPR technologies are designed to help farmers grow with fewer pesticides, less water, and less impact on the environment. While GMO technology is cutting and pasting genetic material from one species into another, CRISPR technology takes this one step further by cutting and pasting genetic material within the same species. Both technologies are safe to grow and eat.

A version of this article was originally posted at Dirt to Dinner and is reposted here with permission. Dirt to Dinner can be found on X @Dirt_To_Dinner

Related Articles

Infographic: Global regulatory and health research agencies on whether glyphosate causes cancer

Infographic: Global regulatory and health research agencies on whether glyphosate causes cancer

Does glyphosate—the world's most heavily-used herbicide—pose serious harm to humans? Is it carcinogenic? Those issues are of both legal and ...

Most Popular

ChatGPT-Image-Sep-2-2026-02_03_32-PM
AI data centers and water usage: It’s a genuine and growing problem
ChatGPT-Image-Mar-10-2026-01_39_01-PM
Viewpoint—“Miracle molecule” debunked: Why acemannan supplements don’t work
ChatGPT-Image-Sep-16-2026-11_28_54-AM
Viewpoint: Study links childhood vaccination to autism!!! Here’s how anti-vaxxers twist evidence to corrupt science
ChatGPT-Image-Sep-21-2026-10_18_59-AM-2
Viewpoint: Is corporate embrace of regenerative agriculture greenwashing?
Screenshot-2026-09-18-at-11.35.25-AM
RFK Jr.’s latest crank obsession: Protecting Americans from perfectly safe electromagnetic radiation
Screenshot-2026-09-16-at-2.26.42-PM
Viewpoint: How to ecologically damage America’s forests: Ban glyphosate
ChatGPT-Image-Sep-20-2026-09_47_55-AM
Trump says he’ll require drugmakers to end multiple vaccine doses, reviving discredited autism claims
Screenshot-2026-09-20-at-9.03.54-AM
From Malaysia to the world: A pioneering science communicator reimagines global science communication for a digital age
Screenshot 2026-09-18 at 10.26
Slowdown AI development? China acknowledges serious risks but sees warnings as U.S. ploy to control the technology
Screenshot-2026-09-16-at-3.14.20-PM
19%: Plunging support for Trump-RFK, Jr. measles vaccine safety oversight
Screenshot-2026-09-20-at-4.31.28-PM
White House drafting executive order to control what OMB Director Vought claims are “woke” NIH science grants
ChatGPT-Image-Sep-17-2026-12_28_43-PM
Vitamin D, omega-3 fish oil and glucosamine supplements could cause brain damage 
glp menu logo outlined

Get news on human & agricultural genetics and biotechnology delivered to your inbox.