Six key health insights from taking weight-loss drugs

Tens of millions of people around the world are now taking drugs like Ozempic — a kind of real-time experiment that offers far more data than a carefully controlled clinical trial can.

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Here’s what we’ve learned in the process.

They can treat much more than just diabetes or obesity.

… [S]ome of them have now been approved to reduce the risk of heart attacks and other cardiovascular issues and to treat sleep apnea, severe liver disease and kidney disease.

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You regain weight if you stop taking them — but not necessarily all of it.

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They don’t work equally well for everyone.

We now know that about one in 10 people on the drugs are what scientists call “non-responders” who lose less than 5 percent of their body weight. 

They can have unexpected downsides. …

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The “right dose” is up for debate.

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They affect more than just your body.

… The idea that the drugs might diminish pleasure, or even joy, in some patients has shown up ….

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