In 2013, the lab of Peter Walter, a biochemist at the University of California, San Francisco (UCSF), discovered a compound—called ISRIB—that blocked the stress response in human cells in a dish…Walter teamed up with UCSF neuroscientist Susanna Rosi to study mouse models of traumatic brain injury [and] wondered whether administering ISRIB would help.
…[When confronted with a maze,] healthy mice got better with practice, but the injured ones didn’t improve. However, when the injured mice were given ISRIB 3 days in a row, they were able to solve the maze just as quickly as healthy mice up to a week later….
If the therapy translates to humans, it could be a boon for soldiers returning from war, who sometimes wait weeks between leaving the battlefield and arriving home for treatment.
[Read the full study here]
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