New therapy could aid battle against drug-resistant bacteria

[T]he first penicillin-resistant pathogen was detected in 1940.

Since then, many other antibacterial drugs (both natural and semisynthetic) have been introduced; however, within a few years of their clinical use, pathogens resistant to those drugs emerged as well.

The recent emergence of a carbapenem-resistant pathogen is the most worrying of all, because this drug is the last known line of defense against microbes that are resistant to multiple antibiotics. This is a growing concern worldwide.


But recent advancement in scientists’ understanding of host-pathogen relationship has given scientists insights into an alternative approach called host-directed therapy (HDT), a suite of treatments whose goal is to enhance the host’s own immune response rather than relying exclusively on antibacterial drugs.

Some promising examples of HD include commonly used drugs for non-infectious diseases—verapamil and metformin, for example which modulate inflammation and increase host antimicrobial response to pathogens; cytokines, a group of proteins that include interleukins, that induce host pro-inflammatory cell signaling to kill pathogens; and nutritional products such as Vitamin D3, which augments the host’s cellular defenses.

Related article:  Why we may need a 'Noah’s Ark' of microbes to protect our health in the future

HDT also aims to balance host reactivity at the site of infection by reducing or preventing an excessive inflammatory response, which can damage internal organs and can even kill. This is achieved through cellular therapy, in which a specific population of bone marrow cells is injected in a host’s body, reducing and preventing tissue.

Read full, original post: A Novel Way to Fight Drug-Resistant Bacteria

Outbreak Daily Digest
Biotech Facts & Fallacies
Genetics Unzipped
Infographic: Deaths from COVID-19 are far higher than reported estimates

Infographic: Deaths from COVID-19 are far higher than reported estimates

More than 2.8 million people have lost their lives due to the pandemic, according to a Wall Street Journal analysis ...

Gilles-Éric Séralini: Activist professor and face of anti-GMO industry

The French biologist and his research team--funded by the Rodale ...
vandana shiva

Vandana Shiva: ‘Rock Star’ of GMO protest movement has anti-science history

In a 2012 interview, Bill Moyers referred to Vandana Shiva as ...
News on human & agricultural genetics and biotechnology delivered to your inbox.
glp menu logo outlined

Newsletter Subscription

Optional. Mail on special occasions.
Send this to a friend