Some of the same genes that influence a person’s propensity toward impulsiveness also affect whether or not he or she will use drugs, according to a new study led by researchers at the University of California, San Diego School of Medicine.
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For this work, and a study [psychologist Abraham] Palmer and his team did last year that also looked at another measure of impulsivity called “delay discounting,” the researchers compared genetic data with survey responses on impulsivity and a history of drug use from 23andMe customers who consented to participate in research. The genome-wide association study found variants in the gene CADM2 — previously implicated in risk-taking, alcohol consumption, and cannabis use — associated with impulsivity and drug use. The team also identified an association with a variant in a gene previously implicated in schizophrenia risk — CACNA1I. They also saw an association with something called “negative urgency”— a tendency to act impulsively in the face of adversity.
These findings demonstrate how an individual’s genetic makeup may predispose them to engage in risky behavior, including drug use and abuse.
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Additional studies of younger and more diverse populations could provide further insights.
Read full, original post: Genetic Study of Impulsiveness Reveals Associations with Drug Use
