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Viewpoint: We should be careful about ‘crossing the germline’ in gene editing humans

| May 22, 2019

Gene editing is one of the scarier things in the science news, but not all editing is the same. It matters if researchers edit “somatic” cells or “germline” cells.

Germline cells are the propogate into an entire organism – either cells that make sperm and eggs (known as germ cells), or the cells in an early embryo that will later differentiate into different functions. What’s critical about those particular cells is that to change or mutation in one will go on to affect every cell in the body of a baby that grows from them. That’s why scientists are calling for a moratorium on editing the genes of germ cells or germline cells .

Somatic cells are everything else – cells in particular organs or tissues that perform a specific function. Skin cells, liver cells, eye cells and heart cells are all somatic. Changes in somatic cells are much less significant than changes in germline cells. If you get a mutation in a liver cell, you will end up with more mutant liver cells as the mutated cell divides and grows, but it will never affect your kidney or your brain.

Our bodies accumulate mutations in somatic tissues throughout our lives. Most of the time humans never know it or suffer any harm. The exception is when one of those somatic mutations grows out of control leading to cancer.

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Germ cells are the cells – egg and sperm – that make a baby. Editing genes in these cells will cause permanent changes in the child and all of their progeny. Image: arborelza/Shutterstock.com

I am a geneticist who studies the genetic and environmental causes of a number of different disorders, from birth defects – cleft lip and palate – to diseases of old age like Alzheimer’s. Studying the genome always entails thinking about how the knowledge you generate will be used, and if those are likely to be ethical. So geneticists have been following the gene editing news with great interest and concern.

In gene editing, it matters enormously if you are messing with a germline cell, and thus an entire future human being and all its future descendants, or just one particular organ. Gene therapy – fixing faulty genes in individual organs – has been one of the great hopes of medical science. There have been a few successes, but more failures. Gene editing may make gene therapy more effective, potentially curing important diseases in adults. The National Institutes of Health runs a well-respected and highly ethical research program to develop tools for safe and effective gene editing to cure disease.

Related article:  Public opposition to promising CRISPR gene-editing technology is 'tragic,' biotech experts say
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But editing germline cells and creating babies whose genes have been manipulated is a very different story, with multiple ethical issues. The first set of concerns is medical – at this point society does not know anything about the safety. “Fixing” the cells in the liver of someone who might otherwise die of liver disease is one thing, but “fixing” all of the cells in a baby who is otherwise healthy is a much higher-risk proposition. This is why the announcement that a Chinese scientist had done just that created such an uproar.

But even if we knew the procedure was safe, we would be able to catapult us straight into all of the “designer baby” controversies and the problems of creating a world where people try to micromanage their offspring’s genes. It does not take much imagination to fear that gene editing could bring us to a new age of eugenics and discrimination.

Does gene editing still sound scary? It should. But it makes a big difference if you are manipulating individual organs or whole human beings.

Eleanor Feingold is a Professor of Human Genetics at the University of Pittsburgh

A version of this article was originally published on the Conversation’s website asEditing genes should not be too scary – unless they are the ones that get passed to future generations and has been republished here with permission.

The GLP featured this article to reflect the diversity of news, opinion and analysis. The viewpoint is the author’s own. The GLP’s goal is to stimulate constructive discourse on challenging science issues.

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