‘Brute-force approach’ to CRISPR innovation: China stakes out global leadership role developing medical treatments, transplantable organs, quality meat

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A gene-edited macaque with circadian rhythm disorders from whom five monkeys were cloned at a research institute in Shanghai. Image: Xinhua

China now has at least four groups of CRISPR researchers doing gene editing with large colonies of monkeys. โ€œThe most startling part of what is coming out of China is seeing how they have just a brute-force approach,โ€ says reproductive biologist Jon Hennebold at the Oregon National Primate Research Center in Hillsboro. โ€œThe level of animal support they have to do those experiments is really astounding.โ€

Itโ€™s not just monkeys. Chinaโ€™s researchers have racked up a long list of CRISPR firsts in dogs, mice, rats, pigs, and rabbits. That research promises higher quality meats, disease-resistant livestock, and new medical treatments and organs for human transplantation. So far, many of the animals are simply proofs of concept. Despite the multitude of CRISPR-altered monkeys, for example, Chinese teams have published โ€œvery little follow-upโ€ [Hennebold said].

But few people doubt that China will persist with its animal-editing binge. โ€œThis is a country and a culture that really values science and technology,โ€ says Jennifer Doudna of the University of California, Berkeley, who helped develop CRISPR into an editing tool. โ€œTheir government has put very serious money into it, and theyโ€™re walking the walk.โ€

Read full, original post:ย Chinaโ€™s CRISPR push in animals promises better meat, novel therapies, and pig organs for people

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