Video: Breaking the COVID genetic code: How genetic data revealed a secret coronavirus outbreak

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Meatpacking plant Agri Star denied having COVID-positive employees - but tracking genetic mutations identified the plant as the epicenter of a major outbreak.

The coronavirus mutatesย as it moves through its victims. Infectious particles swabbed from a patientโ€™s nose carry small but distinctive differences in its genome that can be used, like a molecular bar code, to track where the virus came from and how it had been transmitted. By reading the virusโ€™s RNA, [geneticist Paraic] Kenny could unveil how cases were connected to one another, exposing the secret spread of the disease.

The truth of what happened at [meatpacking plant] Agri Star โ€” and across America โ€” is written in that code.

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Looking at the Postville cluster โ€” more than two dozen yellow dots linked by three distinctive mutations โ€” it was clear to him what happened. The sub-strain started with a single case. But in the crowded conditions of the meat processing plant, it exploded.

โ€œA single viral introduction led to unrestrained spread within the facility,โ€ Kenny wrote inย a study on the website MedRxiv, where scientists post โ€œpreprintโ€ research… His research, he said, showed โ€œthe collateral damage resulting from widespread dissemination of this disease from a meat-packing epicenter across a large midwestern region.โ€

Multiple lines of evidence put Agri Star at the epicenter of this outbreak, Kenny said. The fact that patients from across Postvilleโ€™s diverse communities were infected with the same sub-strain โ€” despite living, shopping and worshiping in different places โ€” suggests they contracted the illness in the one setting they shared: the plant.

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