There are 400 children worldwide with progeria, a rapid-aging disease. Now there’s a potential treatment

Credit: CNIC
Credit: CNIC

The prevalence of [Hutchinson-Gilford progeria syndrome, or] HGPS is approximately 1 in 20 million, so at any given time, there are approximately 400 children living with progeria worldwide… Now, scientists have identified a potential new treatment approach in mice for treating the rare genetic condition.

The researchers used mice with HGPS that produced progerin and inactivated the [isoprenylcysteine carboxymethyltransferase, or] ICMT gene, to observe how their health was affected. They found the mice that lacked ICMT survived significantly longer, and had higher body weights, compared to unmodified mice with progeria. They also had larger skeletal muscle fibers, that resembled those of healthy mice. Their findings are significant as cardiovascular problems are the main cause of mortality in children with HGPS.

Follow the latest news and policy debates on agricultural biotech and biomedicine? Subscribe to our newsletter.

“Our study has taken important steps in validating ICMT as a potential drug target that could provide advantages over existing treatments for children with this fatal condition,” concluded senior author Martin Bergo, professor at the department of biosciences and nutrition, Karolinska Institute.

Further studies are now needed to find compounds that can target ICMT in living organisms, not just in cells, the researchers said. These findings may lead to the development of new effective treatments.

Read the original post

Related article:  Using artificial intelligence to predict who will get sickest from coronavirus
Outbreak Daily Digest
Biotech Facts & Fallacies
Genetics Unzipped
Infographic: How dangerous COVID mutant strains develop

Infographic: How dangerous COVID mutant strains develop

Sometime in 2019, probably in China, SARS CoV-2 figured out a way to interact with a specific "spike" on the ...

Philip Njemanze: Leading African anti-GMO activist claims Gates Foundation destroying Nigeria

Nigerian anti-GMO activist, physician, and inventor pushes anti-gay and anti-GMO ...
News on human & agricultural genetics and biotechnology delivered to your inbox.
glp menu logo outlined

Newsletter Subscription

Optional. Mail on special occasions.
Send this to a friend