Offspring from two males? CRISPR experiment works in mice opening controversial frontier

The researchers aim to eventually try the same technique on larger animals, including monkeys. Credit: Zhi-kun Li et. al
The researchers aim to eventually try the same technique on larger animals, including monkeys. Credit: Zhi-kun Li et. al

The concept of biological reproduction between same-sex individuals in mammals has always been deemed impossible. However, scientists have now successfully created a bi-paternal mouse (with two fathers) in a lab, which survived into adulthood. …

…

[I]nstead of trying to create eggs, they focused on precisely editing specific parts of the genetic code, particularly twenty genes known to be crucial for embryo development. Aiming to create healthy mice with DNA from two fathers, the team undertook a complex series of experiments to individually modify these critical genes using various techniques with the CRISPR tool.

…

With the use of CRISPR technology, researchers found that the genetic modifications allowed the creation of longer-living bi-paternal animals … the study’s results mainly demonstrated that “imprinting anomalies are the primary barrier to unisexual reproduction in mammals,” according to Guan-Zheng Luo, co-author of the study and researcher at Sun Yat-sen University in Guangzhou.

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