Promising gene therapy could help kill tumors

The GLP aggregated and excerpted this blog/article to reflect the diversity of news, opinion and analysis.

Cancer scientists toiling in one of the world’s largest research clusters are setting their sights on what could become a game-changing approach to battling hard-to-treat tumors.

Experiments at Novartis Institutes for BioMedical Research and the Broad Institute of MIT and Harvard, described in a pair of papers published in the medical journal Science, identified the gene PRMT5 as a promising target that drug developers can use in knocking out cancer cells.

While the full impact of their findings isn’t yet clear, Novartis has deployed between 30 and 40 researchers here to screen drug compounds aimed at PRMT5, which they have linked directly to some of the most intractable blood, brain, and pancreatic cancers.

Two research teams across town at the Broad, meanwhile, are engaged in follow-up studies to better understand the mechanisms of PRMT5 and determine if there might be other drug targets that function in similar ways.

Related article:  Global consensus finds neonicotinoids not driving honeybee health problems. Why is Europe determined to ban them?

Researchers caution they are a long way from fielding effective cancer medicines based on discoveries from their experiments, code-named Project Drive at Novartis and Project Achilles at the Broad. But if their initial hypotheses pan out, the work could open a new cancer research field and give industry and academic drug discovery teams an important new tool.

“This is an exciting new research target,” said Bill Sellers, global head of oncology at Novartis Institutes. “If we can make the right therapy, it would selectively kill tumors.”

Read full, original post: Targeting the ‘gene next door’ to fight hard-to-treat tumors

Outbreak Daily Digest
Biotech Facts & Fallacies
Talking Biotech
Genetics Unzipped
Video: Test everyone – Slovakia goes its own way to control COVID

Video: Test everyone – Slovakia goes its own way to control COVID

As Europe sees record coronavirus cases and deaths, Slovakia is testing its entire adult population. WSJ's Drew Hinshaw explains how ...
mag insects image superjumbo v

Disaster interrupted: Which farming system better preserves insect populations: Organic or conventional?

A three-year run of fragmentary Armageddon-like studies had primed the journalism pumps and settled the media framing about the future ...
dead bee desolate city

Are we facing an ‘Insect Apocalypse’ caused by ‘intensive, industrial’ farming and agricultural chemicals? The media say yes; Science says ‘no’

The media call it the “Insect Apocalypse”. In the past three years, the phrase has become an accepted truth of ...
globalmethanebudget globalcarbonproject cropped x

Infographic: Cows cause climate change? Agriculture scientist says ‘belching bovines’ get too much blame

A recent interview by Caroline Stocks, a UK journalist who writes about food, agriculture and the environment, of air quality ...
organic hillside sweet corn x

Organic v conventional using GMOs: Which is the more sustainable farming?

Many consumers spend more for organic food to avoid genetically modified products in part because they believe that “industrial agriculture” ...
benjamin franklin x

Are most GMO safety studies funded by industry?

The assertion that biotech companies do the research and the government just signs off on it is false ...

Environmental Working Group: EWG challenges safety of GMOs, food pesticide residues

Known by some as the "Environmental Worrying Group," EWG lobbies for tighter GMO legislation and famously puts out annual "dirty dozen" list of fruits and ...
m hansen

Michael Hansen: Architect of Consumers Union ongoing anti-GMO campaign

Michael K. Hansen (born 1956) is thought by critics to be the prime mover behind the ongoing campaign against agricultural biotechnology at Consumer Reports. He is an ...
News on human & agricultural genetics and biotechnology delivered to your inbox.
Optional. Mail on special occasions.
Send this to a friend