There are lots of things you can do to keep your heart healthy and hopefully live longer. But a new review suggests that most dietary changes and supplements won’t move the needle much, if at all. Some supplements might even slightly increase your chances of a stroke.

The study, published [July 9] in the Annals of Internal Medicine, is a deep dive into the links between our diet and supplement habits and our cardiovascular health. It’s a review of nine past meta-analyses of randomized and controlled clinical trials as well as four other trials—amounting to more than 270 trials involving nearly a million volunteers. These trials asked people to try out a total of 24 interventions, such as taking a certain supplement or switching to a Mediterranean diet, and compared them to control groups.

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But they found no evidence that taking supplements containing vitamins B6 and A, multivitamins, iron, or antioxidants led to any change in people’s risk of cardiovascular disease or dying earlier. 

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“Do not waste your money on these supplements,” study author Safi Khan said in a video statement released by the American College of Physicians, which publishes the Annals of Internal Medicine.

Read full, original post: Most Supplements and Dietary Changes Do Squat for Your Heart, Large Research Review Finds