When does aging begin to accelerate? Earlier than most people think

Slowing accelerated biological aging
Credit: Midjourney/ Heenan

A groundbreaking new study has revealed that your body doesn’t age in a straight line. Instead, it hits a sudden ‘turning point’, and much earlier than most people would guess. Using detailed proteomic age clocks, the team tracked age-related protein changes in tissue samples from dozens of donors, uncovering that blood vessels, the adrenal glands, and other systems begin aging faster than many expect.

A new study, published recently in Cell, has identified a turning point at which that acceleration typically takes place: at around age 50.

After this time, the trajectory at which your tissues and organs age is steeper than the decades preceding, according to a study of proteins in human bodies across a wide range of adult ages, and your veins are among the fastest to decline.

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The most dramatic shifts were seen in donors between the ages of 45 and 55. During this period, many tissues experienced significant proteomic changes, especially in the aorta, which appeared highly vulnerable to aging. Notably, longer-lasting alterations were also observed in the pancreas and spleen.

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