Low-hanging fruit: How the first generation of GMO crops yielded massive economic and environmental benefits

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The first generation of GM crops was produced using methods that add genetic material to the crop plant’s genome. This approach, generally referred to as recombinant DNA (rDNA) technology, is based on the construction of hybrid molecules comprising a gene (or genes) and regulatory sequences from virtually any source. The hybrid construct is replicated in a bacterial plasmid or viral genome, then transferred into plants, which are then referred to as GM or “transgenic”.

Most of the GM varieties on the market today were developed using rDNA technology and commercialized by biotech companies, largely because of the high cost of both developing them and complying with regulatory requirements.The ringspot virus-resistant papaya is the only exception, having been developed by university-based researchers.

The most widely grown GM crops are cotton, corn, soybeans and canola modified by the introduction of genes that confer herbicide tolerance, insect resistance Other crops either already on the market or just entering it include alfalfa, sugar beets, squash, eggplant, potatoes and apples are.

[Editor’s note: This is part two of a four-part series on the progress of agricultural biotechnology. Read part one, part three and part four.]

Both herbicide-tolerant and insect-resistant crops have been adopted at breakneck speed in every country in which they have received regulatory approval. As of 2018, the latest year for which statistics are available, GM crops were grown on 474 million acres in 26 countries. This represents a more than 100-fold expansion in GM crop acreage over the 23 years since their commercial introduction in 1996. By 2018, the adoption rates of biotech crops exceeded 90% in the top 5 adopting countries (USA, Brazil, Argentina, Canada and India).

soybean brazil

The rapid adoption of GM crops has returned benefits substantially beyond expectations. A 2014 study on the cumulative global impact of GM crops since 1996 concluded that farmers’ yields increased by 22% and their profits by 68%.8 A more recent study reported that the net economic benefit at the farm level was roughly $18 billion for 2016 and 186.1 billion for the period 1996-2001.9

The economic benefits have come both from yield gains and from reduced production costs (65% and 35%, respectively). As well, the adoption of GM technology has increased global yield levels for commodity crops such as soybeans and corn (213 million and 405 million metric tons, respectively). Importantly, the study pointed out that the economic benefits have been divided roughly equally between developing and developed countries (48% and 52%, respectively).9

A cumulative environmental assessment spanning 1995-2016 found that the use of GM crops reduced the environmental impact of herbicide and pesticide use by 18.4% as measured by the Environmental Impact Quotient.10,11 The study further pointed out that the use of herbicide tolerant crops reduced agricultural fuel use, primarily by facilitating no-till farming, and estimated that the reduction for 2016 alone was equivalent to removing 16.7 million cars from the roads.11

In sum, the adoption of a small number of GM crops, principally cotton, soybeans, corn and canola, by a large number of farmers has brought substantial economic benefits to farmers and made significant contributions to both the productivity and sustainability of agriculture. It is worth emphasizing that the economic benefits are scale-independent, benefitting both small- and large-scale farmers.

Is there more low-hanging fruit to be harvested?

There are still no widely available GM varieties of either wheat or rice, the second and third most widely grown and consumed grains.12 Monsanto, for example, halted development of GM herbicide-tolerant wheat in 2004 because the market appeared insufficient to recover development costs and because there was significant resistance to GM wheat from some U.S. buyers, as well as buyers in export markets.13

wheat seeds
Image: GMO Awareness

Indeed, Japan halted import of wheat from areas where small amounts of Monsanto-developed herbicide-tolerant wheat were discovered in Oregon in 2013,14 and both Japan and Korea did so when GM wheat was detected in Alberta, Canada in 2017.15 Similarly, an Argentinian agricultural biotechnology startup company called Bioceres developed a drought-tolerant wheat variety, but failed to receive government approval for release because of fears that it would depress Argentina’s wheat export market.16

The introduction of both herbicide-tolerant and drought-tolerant wheat varieties would benefit both farmers and the environment, reducing production costs and stabilizing wheat supplies in the face of a warming climate. Nonetheless, perceptions about consumer acceptance in both domestic and export markets continue to influence regulatory and commercial decisions.17

Genetic modification of rice, which is arguably the world’s single most important food crop, is as problematical as that of wheat. Rice provides a third to two thirds of the calories consumed by a third of the world’s population and 90% of it is grown in Asia.18 One of the major challenges in rice production is the prevalence of weedy relatives capable of interbreeding with domesticated varieties.19

In the mid 1990s, AgroEvo (now part of Bayer) had developed a GM variety of rice called Liberty Link (LL601) that was tolerant to the herbicide glufosinate. It had been field-tested in Louisiana and Arkansas and had received regulatory approval from both the USDA and the FDA for its release (technically referred to as ‘deregulation’), but commercialization was suspended in 2001.20 In 2006, LL601 was detected in several European countries, damaging the U.S. rice export market. U.S. rice growers sued Bayer, which settled the suit for $750 million in 2011.21

Insect-resistant Bt rice was developed in China in the 1990s and received regulatory approval in 2009, but has yet to be commercialized.22 This has been attributed variously to consumer and agribusiness leader concerns about GM food consumption.23 Paradoxically, China is one of the world’s largest importers of GM crops, particularly soybeans, canola and corn.23 Moreover, Bt cotton has been grown in China since 1997, achieving an adoption rate of 96% by 2015.23

Bms rice planting rwg

It has been estimated that the decade of delay in approving Bt rice has cost China roughly $12 billion a year.22 In view of the fact that Bt crops have been shown to reduce pesticide use and Chinese farmers are among the top users of pesticides, the foregone benefits include reduced exposure of both farmers and consumers to pesticides. Thus despite potential health and economic benefits, whether GM wheat and rice varieties are commercialized is determined by a complex mix of consumer attitudes, regulatory rulings, business decisions and even political considerations.23,24

No good deed goes unpunished

Perhaps the most famous GM rice variety just now poised to enter the marketplace is the so-called humanitarian Golden Rice.25 Vitamin A deficiency is arguably the most pervasive and consequential global nutritional deficiency.26 Starting in the early 1990s and funded by the Rockefeller Foundation, Swiss scientists Ingo Potrykus and Peter Beyer took up the challenge of introducing genes that would support the biosynthesis of beta-carotene, a vitamin A precursor, in rice endosperm.27

misguided

Despite widespread skepticism, they succeeded within a decade, creating what by then had been dubbed “Golden Rice”.28 Time magazine published Potrykus’ picture on its cover with the bold prediction: “This rice could save a million kids a year”.29 The story of the ensuing setbacks and savage attacks by anti-GMO activists is an absorbing, sobering tale.25,30 Only now, 20 years after it was first accomplished in the laboratory, is Golden Rice inching toward release to farmers.

Related article:  Podcast: CRISPR might save the banana from deadly disease. Will consumers get behind the technology?

Regulators in the U.S., Canada, New Zealand, and Australia have approved Golden Rice for growing and consumption.31 In Bangladesh, where almost a fifth of children suffer from vitamin A deficiency, Golden Rice was approved by the Ministry of Agriculture, but the Ministry of the Environment seized the regulatory initiative, as it had in India a decade earlier, and failed to give its approval for commercialization.32

The Indian Environmental Minister’s 2010 temporary moratorium on Bt brinjal (eggplant) brought a complete halt to the further introduction of GM crops that has persisted to the present, although farmers are increasingly defiant.33 In the meantime, the GM insect-resistant eggplant developed in India was introduced successfully in Bangladesh, increasing farmer incomes, reducing insecticide use and insecticide poisoning and achieving good consumer acceptance.34

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And still, the cacophony surrounding Golden Rice continues. Now that Philippine regulators and legislators are close to approving it for human consumption, Greenpeace has amped up its opposition.35 As well, whether Golden Rice succeeds in its original objective of alleviating vitamin A deficiency also depends on how – and how widely – it is consumed by people whose diets consist largely of rice and who are therefore at risk of vitamin A deficiency.36

In sum, the early focus by biotech companies on commodity crops largely used for animal feed, fiber or processed products brought major benefits to farmers, consumers and the environment. Widely consumed grain crops, particularly rice and wheat, have not fared as well for a variety of reasons, including both consumer resistance and the diversity of governmental positions on GM crops, as well as litigation by parties injured by the uneven global acceptance of food crops improved by molecular methods. Golden Rice, the one humanitarian GM project meant solely to benefit impoverished people, continues to be a lightning rod for every manner of assault on GM technology. And whether in the end it will succeed in alleviating one of humanity’s most serious nutritional deficiencies remains an open question.

1Birch RG (1997). Plant transformation: problems and strategies for practical application. Annu Rev Plant Biol 48:297-326; Fedoroff NV and Brown NM (2004). Mendel in the Kitchen: A Scientist’s View of Genetically Modified Food. (Joseph Henry Press, Washington DC), p.370.

2McDougall P (2011). The cost and time involved in the discovery, development and authorisation of a new plant biotechnology derived trait. Crop Life International  https://croplife.org/plant-biotechnology/regulatory-2/cost-of-bringing-a-biotech-crop-to-market/

3Kishore GM et al. (1992). History of herbicide-tolerant crops, methods of development and current state of the art–emphasis on glyphosate tolerance. Weed Technol 6:626-34; Knežević S (2016). Weed resistance and new herbicide tolerant crops in USA. Acta Herbologica 25:35-42.

4Hilder VA and Boulter D (1999). Genetic engineering of crop plants for insect resistance–a critical review. Crop Protection 18:177-91.

5Lombardo L et al. (2016). New technologies for insect-resistant and herbicide-tolerant plants. Trends Biotechnol 34:49-57.

6ISAAA (2018). Brief 54: Global status of commercialized biotech/GM crops: 2018. ISAAA 

7Gonsalves D (1998). Control of papaya ringspot virus in papaya: a case study. Annu Rev Phytopathol 36:415-37.

8Klümper W and Qaim M (2014). A meta-analysis of the impacts of genetically modified crops. PloS One 9:e111629.

9Brookes G and Barfoot P (2018). Farm income and production impacts of using GM crop technology 1996–2016. GM Crops & Food 9:59-89.

10Kovach J et al. (1992). A method to measure the environmental impact of pesticides. New York Food Life Sci Bull 139:1-8.

11Brookes G and Barfoot P (2018). Environmental impacts of genetically modified (GM) Crop use 1996–2016: Impacts on pesticide use and carbon emissions. GM Crops & Food 9:109-39.

12Wulff BB and Dhugga KS (2018). Wheat—the cereal abandoned by GM. Science 361:451-2.

13Stokstad E (2004). Monsanto pulls the plug on genetically modified wheat. Science 304:1088-9.

14AP. Japan suspends some imports of U.S. wheat. New York Times, 31 May 2013 https://www.nytimes.com/2013/05/31/business/global/japan-suspends-some-imports-of-us-wheat.html

15Obayashi Y and Rod N. Japan suspends sale of Canadian wheat after GMO wheat found in Alberta. Reuters, 15 June 2018 https://www.reuters.com/article/us-canada-wheat-gmo-japan/japan-suspends-sale-of-canadian-wheat-after-gmo-wheat-found-in-alberta-idUSKBN1JB100

16Gilbert J. Drought-sltricken wheat belts offered a thorny solution from Argentina. Bloomberg, 12 March 2019 https://www.bloomberg.com/news/articles/2019-03-13/drought-stricken-wheat-belts-get-thorny-solution-from-argentina

17Malcolm B (2017). Agribusiness perspectives on transgenic wheat. in Wheat Biotechnology (Springer, New York), pp. 113-26.

18Khush GS (1997). Origin, dispersal, cultivation and variation of rice. Plant Molec Biol 35:25-34.

19Nadir S et al. (2017). Weedy rice in sustainable rice production. A review. Agron Sustain Develop 37:46.

20Lemaux PG (2007). LL601 rice: What is it and what does it mean? http://ucbiotech.org/resources/factsheets/LibertyLink.pdf

21Harris A and Beasley D. Bayer will pay $750 million to settle gene-modified rice suits. Bloomberg, 1 July 2011 https://www.bloomberg.com/news/articles/2011-07-01/bayer-to-pay-750-million-to-end-lawsuits-over-genetically-modified-rice

22Jin Y et al. (2019). Cost of postponement of Bt rice commercialization in China. Frontiers Plant Sci 10:1226.

23Deng H et al. (2019). Perception and attitude toward GM technology among agribusiness managers in China as producers and as consumers. Sustainability 11:1342.

24Demont M and Stein A (2013). Global value of GM rice: a review of expected agronomic and consumer benefits. New Biotechnol 30:426-36.

25Regis E (2019). Golden Rice: The Imperiled Birth of a GMO Superfood. (Johns Hopkins University Press, Baltimore, Maryland), p.234.

26Wiseman EM et al. (2017). The vicious cycle of vitamin A deficiency: a review. Critical Rev Food Sci Nutrition 57:3703-14.

27Potrykus I (2001). Golden rice and beyond. Plant Physiol 125:1157-61; Zeigler RS (2014). Biofortification: Vitamin A deficiency and the case for golden rice. in Plant Biotechnology (Springer, New York), pp. 245-62.

28Ye X et al. (2000). Engineering the provitamin A (β-carotene) biosynthetic pathway into (carotenoid-free) rice endosperm. Science 287:303-5.

29Nash JJ. This rice could save a million kids a year. Time Magazine, 31 July 2000, http://content.time.com/time/magazine/article/0,9171,997586,00.html

30Dubock A (2019). Golden Rice: To combat vitamin A deficiency for public health. in Vitamin A (IntechOpen, London). 10.5772/intechopen.84445

31Stokstad E (2019). After 20 years, Golden Rice nears approval. Science 366:934.

32Chandran R. Debate over GM eggplant consumes India. Reuters, 16 February 2010 https://www.reuters.com/article/us-india-food/debate-over-gm-eggplant-consumes-india-idUSTRE61F0RS20100216; Begum S. No Golden Rice farming now. The Daily Observer, 1 December 2019 https://www.observerbd.com/details.php?id=231149

33Editors. They want GM crops: Farmers’ revolt is the outcome of a decade long political paralysis, which must end. The Times of India, 26 June 2019, https://timesofindia.indiatimes.com/blogs/toi-editorials/they-want-gm-crops-farmers-revolt-is-the-outcome-of-a-decade-long-political-paralysis-which-must-end/

34Ahmed AU et al. (2019). Impacts of Bt brinjal (eggplant) technology in Bangladesh. International Food Policy Research Institute of Bangladesh  https://www.ifpri.org/publication/impacts-bt-brinjal-eggplant-technology-bangladesh

35Dubock A (2020). Title. Genetic Literacy Project https://geneticliteracyproject.org/2020/01/29/viewpoint-on-the-wrong-side-of-humanity-and-science-greenpeace-philippines-launches-last-gasp-effort-to-derail-gmo-golden-rice-approval/

36Kaguongo W et al. (2012). Factors influencing adoption and intensity of adoption of orange flesh sweet potato varieties: Evidence from an extension intervention in Nyanza and Western provinces, Kenya. African J Agricult Res 7:493-503; Birol E et al. (2015). Developing country consumers’ acceptance of biofortified foods: a synthesis. Food Security 7:555-68.

Nina V. Fedoroff is an Emeritus Evan Pugh Professor at Penn State University.

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