Viewpoint: Organic farming and sustainable agriculture are often in conflict. Here’s why

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When it comes to denying science, California leads America, and sometimes the world. In early 2020, for example, when the President of the US said to cut travel from China due to SARS-CoV-2, Governor Newsom said he was xenophobic and racist and that since the World Health Organisation denied it was a pandemic, he was opposed to science also.

Credit: Hank Campbell

Prior to that it was a state where we had to hammer the legislature for 10 straight years to eliminate arbitrary exemptions from vaccines, because California schools on the coast had more unvaccinated kids than the rest of the US combined. Prior to that, they tried to ban modern agriculture, along with Happy Meals and Golf.

People ‘east of the 5’, as we say to note the demarcation line from Jenny McCarthy Acolytes to sane people who don’t think Whole Foods produce is grown without pesticides, got most anti-science efforts kicked to the curb at the state level, but one county did ban modern agriculture. In 2004, Mendocino banned GMOs.

Scientifically, it was weird. There is exactly one grape in the world that has not been genetically engineered in the last few hundred years. Everything else produced is a ‘GMO’ the way that anti-science hippies use it. Yet they weirdly even got that wrong.

GMO is a legal term, a specific process, and there are no GMO grapes. By banning GMOs, they were saying that products which don’t exist couldn’t be used, but if a grape was invented using Mutagenesis – literal chemical and radiation baths to force new mutations – it is certified organic.

They knew there were no GMO grapes, their voters were instead so dumb that they believed that if even GMO corn were grown in the county, it would magically transform from corn into grapes and create vineyards full of Frankengrapes. Even Tom Philpott at Mother Jones never wrote anything so stupid in support of organic food, and he really tried.

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None of it made any scientific sense then or now. Molecular biologist Professor Maarten Chrispeels at the University of California San Diego goes into a brief history of how organic industry activists and the journalists at places like Mother Jones who promote alternative ag have deceived the public. They have consistently lied about using no pesticides (they use copper sulfate, which is just older and less effective, requiring far more of it), no genetic engineering (there are thousands of strains created using Mutagenesis and plenty are certified organic) and they lie claiming that they are more “natural” and sustainable.

Farming is not natural and never has been and if you want “sustainable”, using the process with the smallest environmental footprint per calorie, you need modern science – not thanking Gaia while you dump 600% more older pesticides on your plants.

Or you can engage in the same thinking that afflicts the super-majority on the coasts and which NPR lovingly virtue signals toward – that the modern world is killing us and organic food is the only medicine you need.

One thing has changed since Dr. Alex Berezow and I wrote “Science Left Behind” in 2012; Republicans have closed ground on Democrats as anti-vaxxers. But if you think organic food is more natural, healthier, or uses no pesticides, I still know how you vote.

Hank Campbell is the author of Science Left Behind and the founder of Science 2.0. Follow Hank on X @HankCampbell

A version of this article was originally posted at Science 2.0 and has been reposted here with permission. Any reposting should credit the original author and provide links to both the GLP and the original article. Find Science 2.0 on X @science2_0

Regulatory death march: As the avian flu crosses the species barrier and targets animals and humans, a gene editing solution is in focus. Here’s why it’s unlikely US regulators will embrace the moment

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Avian influenza is surging again, but with an even deadlier twist: the scourge that has led to hundreds of millions of bird deaths since it was first documented in the 19th century may soon pose a COVID-like threat to humans.

The current iteration of bird flu, known as H5N1, has been escalating since the 1990s as the world poultry population surged exponentially to meet escalating food demand. It claimed its first known human victims in 1996-97, in China and Hong Kong, spread to Cambodia in 2003, and then reappeared with a vengeance a decade ago. According to the World Health Organization, it killed nearly 60% of the more than 800 people infected between 2003 and 2016. The majority of human H5N1 infections and deaths occurred in Egypt, Vietnam and Indonesia.

This is part one of a two-part series. Read part two here.

Despite these limited examples of person-to-person transmission, there are no known examples of widespread, sustained transmission among humans or any mammals for that matter. However, virus evolution called “antigenic shift” could give rise to the emergence of novel viral subtypes able to target mammals. 

Recent isolated cases among humans have heightened concerns. At least six people were infected by H5N1 in Cambodia during 2023, four fatally. Last summer, at least two human fatalities in Poland were linked to a mystery outbreak among cats.

The deaths have public health officials worldwide on edge as fears mount that newly-mutated strains could lead to direct human-to-human transmission. Calls for more proactive global surveillance are escalating. Some scientists warn that a global health crisis that could rival the COVID-19 pandemic cannot be ruled out.

There is a promising solution that could protect birds and mammals, including humans, but, unfortunately, it is not being aggressively pursued. Gene-editing tools in development could likely contain H5N1 in birds by creating flu-resistant strains of chickens. A group of British scientists has used the CRISPR gene-editing system to tweak a specific chicken gene, ANP32A, that codes for a protein essential for the replication of the avian flu virus. The flu resistance traits were heritable and transmitted to offspring. But bureaucratic bungling, decades of misguided regulation, and doomsday claims by opponents of biotechnology innovation are blocking this promising solution.

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Magnitude of the crisis as H5N1 spreads to mammals

There are currently no good ways to contain avian flu. Vaccinations are theoretically an option but are impractical; there are just too many birds. Each year in the U.S., approximately 8 billion chickens are slaughtered for their meat, and another 300 million are maintained for laying eggs. 

Over the past 25 years, the US alone has recorded 72 million avian infections linked to H5N1 in commercial flocks, and wild birds, including gulls and terns, have also been affected, according to the US Department of Agriculture. According to the World Health Organization, more than 131 million domestic birds in 167 countries were lost due to infection or culling in affected farms and villages in 2022; and in 2023, another 14 countries reported outbreaks, mainly in the Americas. Some wild bird species are at high risk of disappearing altogether.

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Credit: Sanjay Baid, India EPA

The deadliest recent twist is the spread of H5N1 to mammals. Brazil recently reported the deaths of more than 900 seals and sea lions, and thousands more were found dead last summer in Chile and Peru. 

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Credit: Peru National Parks

Washington State is on alert after dozens of seals showed up dead off the Olympic peninsula, alarming scientists.  H5N1 has also infected large numbers of foxes, raccoons, skunks, grizzly bears and dolphins.  Local authorities in all of these areas are scrambling to contain its spread, and warning humans not to touch the dead animals.

What can be done? 

Many “zoonotic” viruses other than H5N1 spread readily in animals and can cross over to humans, although the latest variant is particularly lethal. New strains can arise that infect new hosts and evade immunity conferred by infection with their predecessors. Public health experts are concerned that that could happen with the H5N1 virus, and that the new viruses may be sufficiently different that most people will not have immunity to these “immune-escape” mutants. 

There are two ways that new variants arise. “Antigenic drift” is caused by mutations in the virus’ RNA that change the virus’ surface proteins — hemagglutinin (HA) and neuraminidase (NA). Those mutations usually produce closely related viruses, so that antibodies elicited by exposure to one flu virus will likely recognize and neutralize to some degree the parental strain and other viruses that arose via antigenic drift.

Another, more drastic type of change, is called “antigenic shift,” which gives rise to new, significantly different HA and/or NA proteins in flu viruses that enable them to infect humans. This is more likely to occur when there is co-infection by different viruses — for example, human and avian flu viruses simultaneously infecting an animal host — giving rise to reassortment of viral RNAs and the emergence of a new hybrid virus containing parts of the genomes of two distinct viruses. The new viruses may be sufficiently novel that most mammals, including people, do not have immunity to them.

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Credit: Brittanica

Dogs, cats, and wild birds, as well as some livestock such as pigs, ducks, and chickens, can harbor flu viruses. Many human flu pandemics have resulted when antigenic shifts created new hybrid viruses. Two of the most devastating flu pandemics, the Spanish flu (H1N1) and the Hong Kong flu (H3N2), resulted from such events. 

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What can be done?

Currently, there are no silver bullet solutions to containing the H5N1. Vaccinating chickens each year is impractical, given the numbers involved and the constant evolution of the virus. But gene-editing techniques offer hope. An article in Nature Communications recently described the creation of the world’s first flu-resistant chickens. Scientists at the University of Edinburgh, Imperial College London and the Pirbright Institute used CRISPR to modify ANP32A, the chicken gene that codes for a protein essential for the replication of the avian flu virus. The flu resistance traits were heritable and transmitted to offspring.

To further test the resistance to infection of the gene-edited birds, the researchers exposed them to a second, higher dose of the avian flu virus. The chickens again demonstrated suppression of viral infection, and further viral transmission to non-genome-edited birds with which they were in contact was significantly limited.

That is not the end of the story, however. Viruses are resilient, and the researchers found that in the gene-edited birds, in order to replicate, the virus adapted and enlisted the support of two related proteins, ANP32B and ANP32E. Additional editing to effectively remove from the genome the genes that code for those two proteins eliminated all viral growth in chicken cells. This suggests that editing the single gene the researchers first targeted (ANP32A) is not itself sufficient, so they intend to create new strains of chickens with mutations in all three genes. 

If successful, the ability to confer resistance to avian flu could curtail infections and the culling of our poultry flocks, while at the same time substantially lowering the risk of transmission to wild bird populations — and humans.  This would be of inestimable benefit to chicken farmers and consumers worldwide.

Kathleen L. Hefferon is an instructor in microbiology at Cornell University. Find her on X @KHefferon

Henry I. Miller, a physician and molecular biologist, is the Glenn Swogger Distinguished Fellow at the American Council on Science and Health. He was the founding director of the FDA’s Office of Biotechnology. Find Henry on X @HenryIMiller

Note: This is Part 1 of 2. The second part will discuss the regulatory obstacles to the commercialization of genetically engineered animals.

Viewpoint: Crop biotechnology and chemical pseudo-science exposed — Here’s how the ‘dark money’, tort-lawyer funded Heartland Study dupes journalists and co-ops universities

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Until the 1990s, research was often low-budget, done in government agencies or industry funded. But as universities acquired expensive analytical technologies, as industry science was labeled as biased, as foundations and activist groups started to fund their own scientists and as the journal publication process changed to a digital, market-driven model, so did the science, the scientist and the scientific method.

We are now in a situation where interest groups can come together to fund researchers who can produce data to meet their political or economic interests. The motivations and methodologies behind the Heartland Health Research Alliance (HHRA) funded studies fall into this category.

This is part two of a series. Read part one here.

Part One of the HHRA exposé looked at how funding for the organization and for the Heartland Study were acquired from different interest groups (from mass tort lawyers to the organic food industry lobby). Much of the funding has been channelled into the organization and by extension to their academic “partner” institutions via non-transparent, donor-advised funds and none of the contributions have been publicly declared or responsibly allocated.

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This article examines the scientific approach, the political objectives motivating the researchers and the failures in their methodology.  The scientific method requires intellectual rigor together with independence and integrity. The evidence shows the Heartland Study as anything but.

Activist science

Science is about discovery. A process of gathering evidence and from that drawing inferences and making conclusions. The scientific method involves continually challenging these inferences to ensure more robust conclusions (Karl Popper’s process of resisting falsification). This method has led to the greatest advancements of humanity, prosperity and well-being.

But there are a group of activists and their special interest funders who have perverted the scientific process. They start with a conclusion and then look for evidence that can justify it. Then, rather than challenging their conclusions, they challenge anyone who questions them (often trying to discredit them). This is called “activist science”.

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The Heartland-funded partners and related studies are a clear example of activist science. They start with a conclusion: “that a certain class of herbicides is the cause of pregnancy and infant health issues”. From that they go out to look for evidence that will prove this while designing research parameters without standard control groups to best deliver this conclusion. With the analytical technologies today, chromatographs and spectrometers can be calibrated to detect minute traces of herbicides in pregnant women’s urine and then isolate the cohort to link diseases to these samples.

The conclusions are premeditated because those funding the Heartland research (tort law firms and the organic food industry lobby) are working together with the scientists to deliver conclusions that they will benefit from (either through a large number of lawsuits against herbicide manufacturers or from increased sales of organic food products due to public fear and outrage).

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Correlation is not causation

The false cause fallacy confuses correlation with causation. If every time I go for a run, it rains (correlation), I cannot reasonably conclude that my running practices are the source of the rain (causation). But many activist scientists are relying completely on this fallacy to make their inferences. Cancers are increasing and exposures to novel chemicals are increasing, but there needs to be more research before any causal relationship can be proven. People are living longer, lifestyles are becoming more sedate, cancer detection practices are increasing – there are so many factors that could cause the increase in cancers. Any attempts to correlate this phenomenon on a single factor should be flagged as suspicious scientific practices.

The Heartland Study is relying on this fallacy to legitimize its conclusions. However minute, herbicides are showing up in urine, anywhere and at any time. There could be a thousand other chemicals detected in a pregnant woman’s urine that could cause an issue but these are activist scientists so they are starting with the conclusion that herbicides cause an unspecified number of them. They then manufacture the evidence to justify this preset conclusion. There are no control groups.

To correlate the presence of trace elements of a herbicide with some neonatal issue is not only meaningless, it is irresponsible. But that is what the scientists behind the Heartland Study have been paid to do.

This is an issue of scientific integrity.

Hazard or risk-based research

Activists favor hazard-based research findings while regulators, as risk managers, apply the risk-based approach. There is a big difference here.

A hazard is the possibility that some substance, product, process or event can cause a harm while a risk is the likelihood of this harm given the exposure to the hazard. A car on the street, for example, can be hazardous to humans, but if you are inside your house it is not a risk as you are not exposed to it. Risk managers need to find a way to lower exposures (building crosswalks, stoplights or speed bumps) in order to keep the benefits of vehicles.

If we take the hazard-based approach, then the conclusions would be more precautionary: until we can be certain roads can be made safe, we need to ban cars from the streets or lock people in their homes. This approach is not scientifically sophisticated and is, frankly, quite ridiculous.

The hazard-based approach is used by the International Agency for Research on Cancer (IARC), drawing conclusions with no considerations of exposure levels. This helps to explain how their monographs are continuously attributing carcinogenicity to substances (like glyphosate or aspartame) while no other government agencies have agreed with them.

The Heartland Study takes the hazard-based approach. Given the sophisticated lab testing equipment, the researchers will more than likely identify herbicide traces in the urine of most pregnant women. But the researchers will not reveal how low the levels of exposure are or that the toxicity of the herbicides are so low as to have no impact or play any significant factor in the health of the fetus. The Heartland Study is collecting funding from special interest groups to only show traces of herbicides in urine and then make the correlation with some diseases. They are not concerned with drawing significant conclusions about exposure levels or how they might compare to other more hazardous exposures.

Perhaps the best case of how ridiculous the hazard-based approach is when the Heartland-connected researcher and pesticide class action litigation consultant, Robin Mesnage, admitted that the exposure levels from glyphosate were too low to pose any risk to consumers. Why then has this researcher authored dozens of papers claiming health issues from glyphosate (going back to Séralini’s retracted rat feeding publication)?

It is all a game to this class of activist scientist.

Ramazzini research

As noted in Part 1 of this exposé, the key scientific actors behind the Heartland Study are Collegium Ramazzini fellows. This “club” of mostly American occupational health scientists share a certain set of goals and values. Their careers have often been closely involved in regulatory processes but with a critical view on the utility of the risk management measures in place in government bodies. They have seen too much “industry science” in the process and most of these scientists have become hardened anti-corporate lobbyists.

The Ramazzini culture shows little tolerance for debate or disagreement. Ramazzini fellows are controlling certain journals, controlling issues and who can or cannot contribute while ensuring that the peer review process for their own is anything but critical (see example below). They use their networks in governments and the academe to influence WHO agencies like IARC to publish monographs they can then use in their US tort litigation strategies (see examples from benzene to glyphosate to talc to aspartame).

Ramazzini research is characterized by a small group of networked activist scientists advancing their political interests with the use of poor methodology, the use of the hazard-based approach and conclusions based on confusing correlation with causation. Their publications have been disruptive and noisy but ultimately universally rejected by national scientific agencies. U.S. Congressional hearings have called for an end to taxpayer funding for Ramazzini projects.  But that peer rejection is not a concern for this group as their findings are well-amplified by NGOs, the media, interest groups and US tort lawyers.

They have their own “peers”.

Ramazzini peer review

In the world of legitimate science journal publishing, a rigorous peer review regimen is exercised.

  • Reviewers are credible scientists with demonstrated knowledge and experience in the field of interest.
  • Editors and reviewers alike must sign off that they do not have any personal or professional connections with the authors of a submitted manuscript.
  • Editors must then confirm that none of the reviewers selected have a conflict of interest with the authors or the research involved.
  • Editors also perform quality control, meaning that they must assess what the reviewer writes as to its fairness and rigor. A simple endorsement with no supporting evidence will not work.
  • A reviewer who supplies poor quality feedback must be removed and an additional reviewer must be found who will display the meticulousness required to get the job done.

High quality journals maintain an infrastructure that confirms that these rules are employed, so that there can be no ‘rubber stamping’ of approval of any manuscript for publication without rigorous peer review. The review process can be long and arduous, with multiple renditions of the manuscript being sent back and forth between the journal editor, reviewers and authors.

Do these rules apply to the Ramazzini club? Here is an example of a Ramazzini peer review for an article on glyphosate written by Chris Portier based on research funded by tort law firms suing Monsanto.

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Ramazzini research quality: Peer review by Ramazzini director, Fiorella Belpoggi, of a paper by Ramazzini fellow Chris Portier (funded by US tort law firms) published in the Ramazzini-managed Environmental Health journal

Ramazzini research practices should be distinguished from proper, professional scientific research methodology.

Kathleen L. Hefferon is an instructor in microbiology at Cornell University. Find her on X @KHefferon

David Zaruk is the Firebreak editor, and also writes under the pen-name The Risk Monger. David is a retired professor, environmental-health risk analyst, science communicator, promoter of evidence-based policy and philosophical theorist on activists and the media. Find David on X @Zaruk

A version of this article was originally posted at the Firebreak and is reposted here with permission. Any reposting should credit both the GLP and original article. Find the Firebreak on X @the_firebreak

GLP podcast/video: ‘Paraquat Papers’ — Latest pesticide scandal wrongly links weedkiller to Parkinson’s

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Thousands of pending lawsuits allege that the weedkiller paraquat causes Parkinson’s Disease (PD), a connection its manufacturer tried to hide from regulators and the public for many years. “Documents unveiled as part of ongoing court proceedings in California show that [the chemical company] Syngenta has spent decades investigating the potential side effects of its product,” the LA Times reported in December. “This research has sometimes contradicted public statements issued by the company.”

These allegations have attracted major media attention, but there’s an awkward fact rarely mentioned in the headlines: a large body of research has failed to produce any solid evidence that paraquat exposure causes Parkinson’s.

Podcast:

Video:

Join hosts Dr. Liza Dunn and GLP contributor Cameron English on episode 248 of Science Facts and Fallacies as they break down this recent GLP feature:

Only available to licensed pesticide applicators, paraquat was used in agriculture without incident for many years. Long after it was commercialized, however, scientists discovered the herbicide was chemically very similar to an impurity found in illicit opioids that caused Parkinson-like symptoms in several recreational drug users. This discovery fueled rampant speculation about the risks of paraquat exposure, though subsequent research showed that the herbicide doesn’t cross the blood-brain barrier efficiently enough to cause the neurological damage at the root of PD.

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Studies have also shown that workers at paraquat manufacturing plants, individuals with the highest exposure to the chemical, are no more likely to develop Parkinson’s than the general population. With this data in mind, is there any additional evidence that can help settle the dispute about paraquat and Parkinson’s? Let’s take a closer look at the science and politics surrounding this controversial herbicide.

Dr. Liza Dunn is a medical toxicologist and the medical affairs lead at Bayer Crop Science. Follow her on X @DrLizaMD

Cameron J. English is the director of bio-sciences at the American Council on Science and Health. Visit his website and follow him on X @camjenglish

Phony Whistleblower Gambit: This is how far some environmental activist groups are willing to go to corrupt science for money and ideological gain

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Environmental activists rely on several go-to tactics when fomenting fear of pesticides. One of their favorite methods is recruiting fake whistleblowers, often retired government scientists, who will spread conspiratorial nonsense about regulatory agencies and other researchers. Here’s a real-world example of the “phony whistleblower gambit.”

Activist groups utilize a well-worn set of propaganda tools to turn the public against pesticides. These range from funding junk studies to buying favorable media coverage and filing endless lawsuits against chemical manufacturers. But all these routes of attack are enhanced by a ploy I call the “phony whistleblower gambit.”

The archetypal phony whistleblower is a credentialed scientist, usually a former government official, who uses his reputation to help trial lawyers and environmental NGOs sell anti-pesticide scare campaigns to consumers. Supposedly an academic rebel, this person follows the science wherever it leads. Of course, “the science” inevitably leads to massive paydays for tort lawyers and harsh restrictions on vitally important chemicals.

Here’s a recent, real-world example of the phony whistleblower gambit from the Guardian, authored by journalist-turned activist Carey Gillam and funded by the billionaire-backed Open Society Foundation. Her target is the herbicide paraquat, currently the subject of thousands of lawsuits alleging that the weedkiller causes Parkinson’s Disease.

Let’s dismantle this Potemkin village one pasteboard at a time so you can see how the scheme works, and why it’s so dangerous.

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Don’t trust the EPA, says EPA scientist

According to Gillam, “federal regulators are discouraged from speaking up about potentially dangerous pesticides.” How does she know? Well, an EPA scientist told a major media outlet that EPA scientists are afraid to speak their minds:

Karen McCormack, a retired Environmental Protection Agency (EPA) scientist who spent 40 years with the agency … described a culture of ‘regulatory capture’ at the EPA and said that colleagues who spoke out in favor of more stringent regulations on pesticides were often sidelined.’

We’ve heard this story many times before; it’s the classic progressive tale of corporate malfeasance and it doesn’t stand up to scrutiny. The first issue is that McCormack’s resume is doing all the heavy lifting. She doesn’t substantiate a single allegation she makes about the EPA in Gillam’s article. We’re apparently supposed to take it on faith that McCormack is telling the truth about her sidelined colleagues and the pesticide industry’s ability to “capture” the agency. If her former employer is so corrupt, McCormack should prove it. Her credentials and experience are irrelevant otherwise.

But the allegation is doubly absurd because McCormack is using her reputation as an EPA scientist who “conducted research on pesticides” for 40 years to undermine trust in the very same organization. She can’t advertise her agency experience and assert that everyone else in the place is an industry shill or a fearful bureaucrat who approves pesticides “no matter how high the risk.” Why believe someone who would work in such a sordid environment for four decades?

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Ignoring real issues

Ironically, there is ample evidence that the EPA has succumbed to political pressure in the past, as my colleague Dr. Henry Miller has documented here. Contrary to McCormack’s allegation, however, the problem is the agency’s willingness to collude with anti-pesticide groups, Miller explains:

There is a long and ugly history at EPA of what has been dubbed ‘sue and settle,’ or ‘regulation through litigation,’ whereby regulators encourage legal challenges by environmental activists to their regulatory decisions … That enables EPA to make concessions to the plaintiffs via settlements and consent decrees without the constraints of rulemaking and the scrutiny of the Office of Management and Budget’s Office of Information and Regulatory Affairs.

In recent years the EPA has conceded to activist groups in court on one pesticide after another, including the insecticides sulfoxaflor and chlorpyrifos and the herbicides dicamba, atrazine and paraquat. Many farmers have explained to EPA why these concessions are so devastating. Unnecessarily restricting access to paraquat and other weedkillers, for instance, can increase soil erosion, water pollution and herbicide resistance in weeds, one growers association pointed out in a public comment to the EPA.

Ultimately, this makes growing food for all of us more expensive and challenging. Sadly, farmers get far less attention than activists who lie without hesitation about pesticide safety.

Fibbing about paraquat

Let’s take Gillam’s analysis of paraquat as an example of rampant dishonesty. She claims to have “exposed years of corporate efforts to cover up paraquat’s links to Parkinson’s disease, mislead the public, challenge published scientific literature and influence the EPA.”

But that’s just false. At least 85 studies–funded by governments, pesticide companies and nonprofits–have failed to produce evidence that the herbicide causes Parkinson’s Disease. Even workers at paraquat-manufacturing facilities, who have the highest exposure to the chemical, are no more likely to develop Parkinson’s than the general population.

When paraquat causes harm, it’s usually because someone deliberately misuses it (for example, in a suicide attempt) or doesn’t follow the label instructions when applying it. The activist-friendly EPA adds that it has “found no dietary risks of concern associated with paraquat when it is used according to the label instructions.” That means the vast majority of people (who are only exposed to trace of amounts of pesticides through food) can’t be harmed by the weedkiller.

Gillam points to “secret files” from paraquat manufacturers Syngenta and Chevron to bolster her conspiracy, but this is just smoke and mirrors. When we read the documents themselves instead of relying on Gillam’s and McCormack’s spurious allegations, we can see they contain much of the same information found in publicly available sources. Here’s one example from a 1974 Chevron memo, available on Gillam’s New Lede website:

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Tragic consequences

Governments and corporations do evil things sometimes. True whistleblowers who call out real corruption provide an invaluable service, but that’s not what McCormack is doing. She’s helping dishonest activists like Gillam spread ideological nonsense that has devastating consequences.

Needlessly restricting the chemicals farmers use to grow our food leads to hunger, poverty and political instability—as Sri Lanka found out the hard way recently. Anyone who enables those horrifying outcomes deserve nothing but scorn.

Cameron English is a writer, editor and co-host of the Science Facts and Fallacies Podcast. Before joining ACSH, he was managing editor at the Genetic Literacy Project, a nonprofit committed to aiding the public, media, and policymakers by promoting science literacy. You can visit Cameron’s website here. Find Cameron on X @CamJEnglish

A version of this article was posted at American Council on Science and Health and is used here with permission. You can check out the American Council on Science and Health on X @ACSHorg

Viewpoint: Here’s what happens when legislators pander to activists by over-regulating science and medical practice in an ill-advised effort to ‘protect the public’

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It is bad enough when unqualified pundits offer dumb opinions about science, but bad legislation can cause real damage. The COVID pandemic has given rise to some real legislative doozies from politicians at both the state and federal levels.

I’ve written, for example, about a proposed Idaho bill that would make it a misdemeanor for a healthcare giver to “provide or administer a vaccine developed using messenger ribonucleic acid [mRNA] technology for use in an individual or any other mammal in this state.” As bizarre as it seems, administering an FDA- or USDA-approved vaccine to prevent a potentially lethal disease would be a crime.

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Then there was U.S. Senator J.D. Vance (R-OH), who introduced legislation to prohibit federal mask mandates from being imposed in the U.S. The Freedom to Breathe Act, which would apply through the end of 2024, “would prohibit any federal official, including the President, from issuing mask mandates applying to domestic air travel, public transit systems, or primary, secondary, and post-secondary schools,” according to the senator’s office

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The rationale? According to Vance, “We tried mask mandates once in this country. They failed to control the spread of respiratory viruses, violated basic bodily freedom, and set our fellow citizens against one another.” 

That is like saying that because masks and handwashing in hospital operating rooms fail to prevent all intraoperative infections, mandating them should be prohibited. The logic is preposterous. And as for sowing divisiveness, such absurd pseudo-libertarian legislative proposals go a long way toward that.

The most recent ill-conceived proposal came from the U.S. House of Representatives, which on November 14 approved an insidious amendment to the 2024 spending bill for the Department of Health and Human Services (HHS), the parent agency of the National Institutes of Health (NIH). It would ban federal funding for “gain-of-function” (GOF) research that modifies high-risk pathogens in ways that can make them more harmful. 

As part of their campaign to discredit biotechnology, anti-biotechnology crusaders repeatedly misrepresent such research. The Institute for Responsible Technology—a highfalutin name for a one-man band operation headed by Jeffrey Smith, an unhinged cultist, former flying yogic instructor and graduate from Maharishi University of Management, claims that a GOF could “spread easily between humans [and] could decimate the population.” Smith and other lobbying groups called for a “global ban” starting with “emergency legislation” in the US, and the Republican far right delivered.

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It appears that anti-biotech critics and the authors of the bill, Representatives Thomas Massie (R-KY) and Mariannette Miller-Meeks (R-IA) misunderstood the potentially broad interpretation of “gain of function,” which simply means an organism has acquired a new or enhanced property, and the importance of such research. (And note that such acquisitions occur naturally through horizontal gene transfer, via transformation, transduction, and conjugation.

GOF experimentation that is intended to increase the transmissibility and/or virulence of pathogens usually aims to improve understanding of disease-causing agents, their interaction with human hosts, and/or their potential to spread and cause pandemics. The ultimate objective is to better inform public health preparedness efforts and/or development of medical countermeasures, so it is beneficial.

But the vaguely worded provision in the House bill could unintentionally inhibit important research – for example, on improved vaccines to prevent flu, COVID-19, respiratory syncytial virus (RSV), or other infections that could lead to pandemics. It could even be interpreted to prevent the funding of work on genetically engineered bacteria like the Escherichia coli that are the source of human insulin, or on the genetically engineered yeast that produce Hepatitis B vaccine.

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The amendment was probably spurred by speculation that the original Wuhan variant of the SARS-CoV-2 virus, which causes COVID-19, was the product of GOF genetic manipulation in a Chinese laboratory that was accidentally released. However, the Biological Weapons Convention (BWC) already prohibits the “development, production, acquisition, transfer, stockpiling and use of biological and toxin weapons.” It entered into force in 1975, supplementing the Geneva Convention of 1925. The United States is a signatory of both. 

What is especially disappointing about the Massie and Miller-Meeks GOF amendment to the HHS spending bill is that the two sponsors should recognize its possible unintended consequences. Rep. Massie has two engineering degrees from MIT, and Rep. Miller-Meeks is an ophthalmologist.

It is unclear whether the GOF provision will survive given the partisan divide between the Republican-led House and the Democratic-controlled Senate, which has not yet voted on its own version of the HHS spending bill.

We can only hope that cooler heads will consider the scientific imperatives and dump the GOF restrictions on research funding.

Henry I. Miller, a physician and molecular biologist, is the Glenn Swogger Distinguished Fellow at the American Council on Science and Health. He was the founding director of the FDA’s Office of Biotechnology. Find Henry on X @HenryIMiller

Dissecting claims about Monsanto suing farmers for accidentally planting patented seeds

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A common criticism of genetically modified foods is that their seeds are patented. There are different aspects to this concern: some argue that there should be no patenting of any kind on seeds, while others argue that farmers should not be forced to repurchase seeds. It’s clear that many misconceptions surround the topic of GMOs and patents abound.

Seeds for genetically modified crops are not the only ones that are patented. As documented by the US Patent and Trademark Office, there are many conventionally bred crops that are patented, as well as decorative plants and flowers. Considering the amount of time, money and effort that it takes monsanto-corruptionto create a plant through traditional methods that has the traits and qualities that the breeder desires, it makes sense to protect the investment through a patent.

This same argument applies when it comes to genetically modified crops. According to GMO Answers, the cost of generating a new genetically modified crop is $136 million of an average of seven years, and biotech companies rely on patents to safeguard their investment. These patents are protected through the World Trade Organization (article 27), the International Union for the Protection of New Varieties of Plants (also known as UPOV), and laws of the member nations. Whether or not these patents should exist in the first place is outside the scope of the GMO discussion and could be argued for most patentable or copyrighted items: software, drugs, books, etc.

A common misconception surrounding genetically modified seeds is that they are sterile. This rumor stems from the fact that Monsanto owns a patent on a genetic use restriction technology (GURT), commonly known as the “Terminator” gene or terminator technology, which results in sterile seeds. However, Monsanto has committed to never using this technology and it has yet to commercialize a crop using the technology, despite having had it in hand for nearly 20 years. Additionally, the topic of GURTs was consulted upon at UPOV in 1999, when it was recommended that the technology not be used until the ”economic and socio-economic impacts and any adverse effects for biological diversity, food security and human health have been carried out in a transparent manner and the conditions for their safe and beneficial use validated.”

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Monsanto vs patent violators

Given that GMOs are not sterile, agricultural biotechnology companies rely on legal agreements with growers to ensure that seeds are not replanted from one year to the next. These contracts are generally known as “Stewardship Agreements”, whose details are readily available online. seed-giants-vs-us-farmersMonsanto’s Agreement outlines many aspects of its stewardship program: where products can be distributed, the requirement to plant an insect refuge to prevent Bt-resistant pests, managing glyphosate-resistant weeds, among others. Although most examples in this article focus on Monsanto, other agricultural biotech companies have very similar agreements, including Pioneer and Syngenta. But outside of the context of GMOs, farmers in developed nations generally purchase new seeds each year for hybrid crops to generate higher yields.

Anti-GMO activists regularly claim that Monsanto sues farmers who have accidently reused seeds or found their farms inadvertently “contaminated” by GE seeds. That’s not true. Monsanto does sue farmers who use its seeds without licensing agreements. Arguably, the most famous of these cases was against Canadian farmer Percy Schmeiser, whose story was the focus of the conspiracy-theory-laden documentary “David versus Monsanto”. Schmeiser discovered that his field had been contaminated with Monsanto’s Roundup Ready canola seeds when the land segments surrounding utility poles was sprayed with Roundup. He then admittedly used the seeds from areas where he sprayed with Roundup to replant the following year’s crops.

percy-field4Schmeiser’s legal team for the federal court case argued that by releasing the gene into the environment in an uncontrolled manner, Monsanto had lost or waived their rights to an exclusive patent. The judge’s decision concluded that Schmeiser’s arguments defy all evidence. , Witnesses testified that Monsanto removed “plants from fields of other farmers who complained of undesired spread of Roundup Ready canola to their fields.” The judge also found that the level of contamination that had been detected in Schmeiser’s fields through various tests could not be attributed to birds/bees/wind alone. The case was appealed to the Supreme Court of Canada, which ruled in favor of Monsanto. However, its decision was not unanimous. Canadian law excludes patents on higher life forms, and several of the Justices were of the opinion that Monsanto’s patent is enforceable over the cell or gene but not over the plant and its offspring, which is what Schmeiser had “used”.

The biggest court case in the United States between a grower and agricultural biotech company was Bowman vs Monsanto. Bowman is a farmer from Indiana who, according to the court documents, “appreciates Roundup Ready soybean seed”. He bought Monsanto’s seeds and planted them for the first crop of the season. However, for the second and more risky crop of the season, he bought hqdefaultseeds intended for human or animal consumption from a grain elevator and planted these in his field. He then applied a glyphosate-based herbicide, effectively ensuring that the entire crop consisted of Roundup Ready soy plants. Monsanto discovered this practice and sued Bowman.

The basis of Bowman’s defense was patent exhaustion, meaning that once someone has sold a patented item, they no longer control that item and the new owner can do whatever he/she would like with it. The District Court rejected Bowman’s argument, and the Federal Court affirmed it, yet the case made its way to the US Supreme Court. Before reaching its verdict, the Supreme Court received briefs from numerous organizations describing the impact that their ruling would have, including software, biotech and research companies, and economists.

The court gave its unanimous verdict in 2013 stating that patent exhaustion applies only to the item sold, and that the buyer cannot replicate the item. Their opinion states that if purchasers of items were to be able to make endless copies, then the patent would be effective only for the first sale (which is actually the idea behind the Wu-Tang Clan’s latest album). As such, Bowman could have sold the beans he purchased from the elevator grain, or he could have eaten them or fed them to animals. The Supreme Court’s opinion states that by planting the beans, he effectively replicated Monsanto’s patent and the patent exhaustion principle does not apply in this scenario.

Myth: Monsanto sues farmers who unknowingly have GM plants growing

Monsanto has sued well over 100 additional farmers who have used its seeds without licensing agreements and has settled over 700 cases outside of court. In each of these cases, Monsanto has won the court battle. The debate over whether Monsanto has ever sued a farmer who unknowingly used Monsanto’s seeds or whose fields were contaminated with Monsanto’s products was laid to rest in 2013 in the court case known as “OSGATA vs Monsanto.”

The story behind this appeals case began in 2011, when OSGATA (Organic Seed Growers and Trade Association) went before a judge in the Southern District of New York stating that its members had started growing conventional produce because the threat of contamination from GMO was so high. They had to take expensive precautions such as creating a buffer zone, so that they wouldn’t be sued by Monsanto. One grower testified that the only reason why he grew conventional seeds was the threat of a lawsuit from Monsanto, and if this threat didn’t exist then he would go back to growing organic seeds. These growers requested Monsanto to “expressly waive any claim for patent infringement [Monsanto] may ever have against [appellants] and memorialize that waiver by providing a written covenant not to sue.”

At issue was Monsanto’s promise, displayed on its website, to never sue a farmer whose fields have been (unknowingly) contaminated by its seeds. It isn’t a law. It isn’t something that it had sworn to under oath, and at the end of the day, its statement could be false advertising or a PR gimmick. In back-and-forths between lawyers, Monsanto wrote that it has no reason to go after farmers for low level contamination because there’s no financial incentive, and that if the growers/farmers don’t intend to use/sell transgenic seeds, then their fear of a lawsuit is unreasonable. The judge threw out the case based on the fact that “these circumstances do not amount to a substantial controversy and . . . there has been no injury traceable to defendants”.

The case then went to the United States Court of Appeals for the Federal Circuit. The documents for the case state that the appellants have to demonstrate that there’s a substantial risk that harm may occur or that they have to go through expenses/costs to mitigate those risks. But the Organic growers/seed distributors (OSGATA) conceded that Monsanto had never threatened to sue them. OSGATA stated that its fear was based on the fact that Monsanto had taken 144 growers/sellers to court and settled 700 additional cases out of court. Monsanto argued that none of these cases had been due to inadvertent contamination.

However, the way patent laws are written, using even a small amount of a patented material without authorization could constitute patent infringement. For the purposes of the appeal, the judge proceeded with the ruling based on the assumption that inadvertent contamination constitutes patent infringement, and that inadvertent contamination was inevitable.

The record states that the argument would be moot if Monsanto really did not intend to sue, due to the fact that the US Supreme Court has recognized that a covenant not to sue nullifies a controversy between parties. Monsanto has a written policy on its website against inadvertent contamination and the court documents recorded Monsanto’s position on the argument. Monsanto and the organic growers agreed that “trace amounts” meant approximately 1% contamination. The ruling states that although this was not a covenant, it had a similar effect and constituted a judicial estoppel (where you cannot contradict something that has been established as truth by yourself or others).

The court ruling ended with this statement: “the appellants have alleged no concrete plans or activities to use or sell greater than trace amounts of modified seed, and accordingly fail to show any risk of suit on that basis. The appellants therefore lack an essential element of standing.” Yet some in the organic movement spun the verdict as a victory because it now had in writing that Monsanto would never sue for inadvertent contamination–which it had pledged not to do, and never had done.

davidvsmonsanto_posterSo how is it that this myth about Monsanto suing farmers still circulates? Based on clips from the movie “David vs Monsanto“, you could believe that Monsanto plants evidence and works with testing companies to ensure that they will win every court case. You could believe that the 700 court cases that were settled out of court were against farmers who were inadvertently contaminated, but just didn’t have the money to fight Monsanto in court. You could believe that all the court cases had judges and witnesses who were paid off by Monsanto.

Why are seed patents necessary?

My perspective is that Monsanto or any large seed company have better things to do than to sue the small farmer who inadvertently uses thier seeds. From a practical perspective, it would probably represent a greater expense to them in legal fees than what they would recoup through the settlement or court case and such an act would be incredibly harmful public relations.

This article is not meant to excuse the many issues surrounding company earnings or patents. That US patent laws need to be reworked is a given, and was actually highlighted by President Obama at his 2014 State of the Union address. That some companies may be earning what some people may consider as “excessive” is a moral dilemma that is not exclusive to the biotech industry. Having spent a third of my life in South America and having a brother and sister-in-law who worked as physicians in Venezuelan public sector hospitals, I have strong feelings about what companies should be doing in their aid efforts, but again, that is outside the scope of this piece.

What this article is meant to highlight is that patents, for better or worse, may be the only way to provide incentives for innovation while ensuring that a biotech company can recoup development costs. In the same way that copyright laws protect artists and authors, which will probably cause me to pay about $10 to download Bruno Mars’ amazing melodies from iTunes today, patent laws are in place to respect the work of those who have spent the effort, time and money driving a product’s development.

A version of this story was published by the GLP in October 2016.

Layla Katiraee, contributor to the Genetic Literacy Project, holds a PhD in Molecular Genetics from the University of Toronto and is a Senior Scientist in Product Development at a biotech company in California. All opinions and views expressed are her own. Follow her on Twitter @BioChicaGMO 

Viewpoint: While environmentalists and journalists look the other way, anti-vax, pro-organic ‘dark money whore’ US Right to Know partners with organic food and tort lawyer hustlers to undermine science

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In the introduction to this Firebreak series on how foundations fund activists, I noted there were a wide variety of foundations: from generous endowments to publicly funded humanitarian organizations to donor-advised money mills. Many do due diligence and cooperate with their recipients to ensure that the funds are well used. The money mills, though, just take money from a secret donor or interest group, wash it clean of any fingerprints, and, according to the advice of the donor, pass it on to the targeted recipient (minus a hefty laundering fee for the fund manager).

This is the second part of a series. Read part one here.

Donor-advised funds allow activist groups to receive unlimited donations from undisclosed sources. This is important in cases where an NGO, activist, researcher or tort law firm is acting on behalf of the interests of the funders (ie, shilling) and where disclosure of the source might discredit the campaign outcome or reveal a conflict of interest. It allows the NGOs to more easily deceive their public.

This non-disclosure is a sacred part of the donor-advised money mill. If a donor with an interest has no problem having the donation made public, then the funds would be given directly to the recipient rather than paying fees to have the financial source “purified”. It is essentially dark money but unlike mob money in brown envelopes, it is tax deductible. Donor-advised funds are not at all transparent, deceptive and, I would argue, unethical. Since it hides sources of influence, it should be illegal.

In the case of the NGO, US Right to Know, we can also add: hypocritical.

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US Right to Dark Money

The US Right to Know NGO grew out of the failed 2014 Just Label It campaign that demanded transparency and openness on GMOs. They campaign for the right to know who is funding research, organizations and lobbying campaigns and spend their research budget trying to expose companies and industry group activities. Their key objective is to destroy corporations, so they have worked intensely with a large number of US tort law firms, especially around the glyphosate lawsuits and the diffusion of the Monsanto Papers.

As they run anti-capitalist, anti-industry campaigns on behalf of their funders, US Right to Know have mostly focused on exposing pesticides, chemicals, food and pharmaceutical industries. They did try to be transparent on their funding at first but received a lot of criticism as most of their funds came from the organic food industry lobby and some anti-vaccine foundations. Now they are pretending to publish their revenue sources, but almost all of it is dark, donor-advised fund money.

In other words, we really don’t know who is now funding this pack of wolves and can only guess according to the campaigns US Right to Know are hired to run. I suspect a lot of money comes from the equally opaque tort law industry, not only in return for the relentless, pro bono support Carey Gillam gave on the glyphosate-Monsanto trials but also for running the recent public outrage grooming campaigns against Coke in the wake of the IARC aspartame cancer study publication.

Could Gary and Stacy be getting Russian money? Who knows. They used to be regulars on Russia Today.

The graphic below shows how dark and cloudy the US Right to Know’s funding has become over the last two years. As they do not have to declare who their actual sources are, it is left to the imagination which interest groups want this “pay-to-slay” NGO to act on their behalf. The one takehome though is that the next time these self-righteous activists cry about undisclosed corporate funding, the word “hypocrite” should be uttered.

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If we look at the trends over the last five years, the NGO’s fundraising shifted from mostly public to almost all dark, donor-advised funds. This reflects a general trend in foundation giving and the end of NGOs claiming to operate transparently. Some of their funding though is quite unusual or downright bizarre. For example:

  • The largest funder this year, the Adadevoh Memorial Fund, is a Nigerian fund named after a heroic doctor who died from Ebola. Why would a Nigerian healthcare foundation be donating to a left-wing American political activist group?
  • The Centre for Effective Altruism is a controversial donor-advised fund aimed at making young billionaires feel less bad about how they acquired their wealth. As the $200K donated to US Right to Know in 2022 was a one-off along with FTX’s Ryan Salame’s $160K, we can only assume that this is Sam Bankman-Fried cash via the Alameda hedge fund (see image below). SBF spoke glowingly about effective altruism and seemed OK to steal from his hedge fund clients to donate more. (As this is stolen money, if US Right to Know had any integrity, they should give it back to the cheated investors.)
  • Allison Wilson and Jonathan Latham are anti-biotech campaigners who have never disclosed the sources of their funding.
  • Three donor-advised funds: Chicago Community Foundation ($150K), San Diego Foundation ($50K) and Community Foundation of Western North Carolina ($10K) are all committed to alleviating poverty and addressing need in their local communities. UK Right to Know does not do this type of work so we can assume they flipped some donors already involved in their communities and decided to leave their donations dark.

So where did the organic food lobby and anti-vax money go in 2023? Given events, the money surely did not run out, but with all of their donor-advised funds, I’m afraid the rest of us have been left in the dark.

We do not have a right to know and now it’s none of your damn business.

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David Zaruk is the Firebreak editor, and also writes under the pen-name The Risk Monger. David is a retired professor, environmental-health risk analyst, science communicator, promoter of evidence-based policy and philosophical theorist on activists and the media. Find David on X @Zaruk

A version of this article was originally posted at Firebreak and has been reposted here with permission. Any reposting should credit the original author and provide links to both the GLP and the original article. Find Firebreak on X @the_firebreak

GLP podcast/video: Dangers of slanted science coverage; Media falsely claims glyphosate could harm pregnant women

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Exaggerated media coverage distorts the public’s understanding of critically important scientific issues, and the consequences can be dire. How do we combat the harmful effects of sloppy science journalism? There’s no evidence that the weedkiller glyphosate harms pregnant women (or anyone else for that matter), but that hasn’t stopped reporters from trying to embroil the controversial pesticide in yet another scandal.

Podcast:

Video:

Join hosts Dr. Liza Dunn and GLP contributor Cameron English on episode 247 of Science Facts and Fallacies as they break down these latest news stories:

It’s a familiar formula: questionable study makes an exaggerated claim about a chemical; reporters uncritically promote the study’s conclusion; courts and regulators restrict or ban said chemical in a bid to appease consumers misled by the hyperbolic media coverage. Reporters need to do a better job of conforming their science and health coverage to the available evidence. Since they won’t do it themselves, what can scientists and informed laypeople do to hold the media accountable?

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Glyphosate is arguably the most-studied chemical in history, with thousands of papers published over five decades showing that it poses minimal risk to the public, including pregnant women. Nevertheless, headlines routinely assert that mothers and their unborn children could be harmed by exposure to the herbicide. The claim is usually based on low-quality research unworthy of the glowing media coverage it receives. Let’s examine a textbook example of a recent study involving women who live near farms and the Conversation’s misleading reporting about the research.

Dr. Liza Dunn is a medical toxicologist and the medical affairs lead at Bayer Crop Science. Follow her on X @DrLizaMD

Cameron J. English is the director of bio-sciences at the American Council on Science and Health. Visit his website and follow him on X @camjenglish

How ideological foundations and ‘dark money’ seed activist environmental movement and undermine science

Time was that non-profits were funded by their membership dues or individual donations, loose change drums at airports and clipboard brigades on street corners. They listened to their members and conducted open votes on issues and board members.

That was a long time ago.

Time was that foundations and family trusts funded research into deadly diseases, humanitarian missions, scholarships and the fine arts.

This is the first part of a series. Read part two here.

But foundations have changed from the days of Carnegie and Ford. First, there are a lot more of them especially following the massive wealth created during the dot.com, tech and crypto bubbles. And as these bubbles generated much more wealth, existing foundations also grew their coffers immensely.

If money is power, then the dynamics within these foundations have changed from being led by Samaritans to ones led by Samurais aggressively trying to transform political systems. The president of George Soros’ Open Society Foundations, Mark Malloch-Brown, for example, was the former Deputy Secretary-General of the United Nations. And power is network.

This is the introduction to a Firebreak series on how foundations are changing the landscape not just for non-profits, but for political systems and dialogue processes. It will look at a number of foundations that have tilted the balance of power in certain debates by funding an army of activist organizations or directly engaging at political levels. It will try to change the perspective from considering all of these groups as sources of good, giving and charity to ones manipulating spheres of political influence while creating non-representative activist interference.

A recent Firebreak article looked at the cornucopia of foundations that had contributed more than $20 million to The Guardian news organization in return for a certain number of articles published along their interests. One has to acknowledge that this has a negative effect on institutions and the democratic process.

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Stakeholders or steak-eaters?

With a relatively small investment, a single foundation can, for example, fund a dozen NGOs tied to a certain campaign and create enough noise to control the public discourse. And since they are considered as a charitable organizations funding a non-profit that wants to make the world a better place, there is no scrutiny of their activities. They often stay behind the scene while still pulling the strings.

When we speak of stakeholder engagement, a key element of the Western participatory process, we usually mean a dialogue between certain groups like government, the academe, industry and civil society (NGOs). But today we need to consider foundations as an influential stakeholder, if not in place of NGOs, then as a body of its own. If the media is the Fourth Estate, then foundations should be considered as the Fifth or Sixth (if one thinks non-mainstream media still has any real influence).

We’ll see in this series how some foundations, like Bloomberg Philanthropies, not only fund activist groups, they also found them. Their political activism rarely stays below the surface, like the Rockefeller Family Fund organizing and hosting campaign strategy meetings among NGOs and tort lawyers they fund.

Cynically, when I see an NGO today, I don’t look for what they stand for, I look for the foundation whose shoulders they are standing upon. I now have to consider the same when I read an article from a mainstream media source. These well-endowed special interest groups have poisoned the well of public discourse, but in the mainstream, they are trusted as benevolent charities donating funds for the good of humanity.

Raiding the pots of gold

In the early 2000s, when I was involved in setting up a science communications non-profit, GreenFacts, I went to London for a two-day training course on fundraising offered by Blackbaud. Looking back, this was the transition period of non-profits being funded by membership dues to foundation-driven sources (especially as abundant dot.com bubble money was still sloshing about). The trainers advised us in our prospection to focus on foundations, and in particular, to get to know their board members, not just for their networking value, but because the ultimate goal was to get foundation boards filled with “friendly” members.

I was presented with case studies of foundations that had their boards infiltrated by activist networks who shifted a foundation’s strategy and ideology towards certain groups of NGOs. I was surprised how my trainer considered this so positively. A family trust or foundation, two or three generations down the line, can easily lose connection to the original objectives when the founder bequeathed his or her inheritance. We should not be surprised then to see a group like the Rockefeller Brothers Fund, built on Standard Oil wealth, as a major donor to Greenpeace America and actively trying to put ExxonMobil out of business.

There is a well-connected profession of foundation administrators who manage other people’s money and, unsurprisingly, have a lot of friends. They usually step in when foundations have issues, but before long, take over the enterprise, appoint new board members and incrementally shift the giving strategies (often to the left).

These board members and directors are likely to be long-term political activists, directing funding strategies much like generals in a war room sliding battalions around on a map. They have their objectives and demand a return on their “investments”.

A world of foundations

There are many different types of foundations or funds. Some, like the ICRC, Lions’ LCIF or the Wellcome Trust, are doing important humanitarian work, well managed and totally transparent. But many are not and are capable of causing significant societal disruption.

IKEA, for example, is not a company but identifies itself as a non-profit called the Stichting INGKA Foundation based in the foundation fiscal paradise of the Netherlands (but this strategy is shamefully only to avoid paying taxes). UN organizations like UNICEF operate like a foundation. World leaders, Hollywood A-listers and governments have even gotten into the game. Anyone can create a foundation or a trust, including families trying to avoid inheritance taxes.

The Giving Pledge has made forming foundations an obligation for most entrepreneurs who got lucky. Some have the active engagement of their founders seeking some sort of legacy, some are based within companies to encourage employee social responsibility but most are created by a billionaire’s donation and left to others to manage along certain guidelines.

There is though, one type of foundation that pushes the boundaries of charity to rather uncomfortable levels of ethical tolerance. This is known as the donor-advised fund – a type of dark money funding.

Dark money and donor-advised funds

In America, if I want to fund an organization that is acting in my interest, but I don’t want anyone to know, I can give to them via a donor-advised fund. This means I donate to Foundation X, and tell them to administer those funds to NGO Y and, if it doesn’t go against their ethical guidelines (which is often very vague), they do so, discretely and non-transparently … minus their commission of around 10%.

The Tides Foundation is perhaps the best-known donor-advised fund identifying their activities as “partnering with doers and donors to advance social justice”. But as the source of the philanthropy is not disclosed, such funds become tools for dark money to enter into public debates. This is neither transparent nor ethical and should be illegal, but instead, these money mills are tax deductible.

showed how the film, Into the Weeds, which has become a major force in the anti-glyphosate movement, was funded by a little-known donor-advised fund, the Utah Film Center. They would not disclose the source of the film’s funding or the amount. Given that the film was a homage to the tort law industry’s actions against Monsanto, it is not hard to imagine who has been paying these activists’ bills to conduct a global campaign around the film.

Ironically, US Right to Know, an NGO that demands that industry be more transparent, has much of its funding coming from donor-advised funds. We can only suspect this dark money is also coming from tort law firms or organic food industry lobbyists (but with these jackals, we don’t seem to have a “right to know”).

David Zaruk is the Firebreak editor, and also writes under the pen-name The Risk Monger. David is a retired professor, environmental-health risk analyst, science communicator, promoter of evidence-based policy and philosophical theorist on activists and the media. Find David on X @Zaruk

A version of this article was originally posted at Firebreak and has been reposted here with permission. Any reposting should credit the original author and provide links to both the GLP and the original article. Find Firebreak on X @the_firebreak

Nether region science—What’s the allure for cats of fellow feline rear ends?

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Anyone who lives with more than one member of Felis catus knows that our beloved felines love to smell each other’s anal regions. The Internet is full of helpful information on why, but what of it is accurate? 

To answer that question, a research team from the Department of Evolution and Ecology and Genome Center University of California, Davis analyze the practice in felines and even compares them with anal gland emissions studies of several other mammals, including dogs, hyenas, foxes, pandas, and even humans. The findings are published in Scientific Reports.

Cats begin a potential social encounter with hesitant head sniffing, which may progress to light head bumping as pheromones waft from facial glands. Pheromones are chemicals that trigger a social response in members of the same species. Hormones, in contrast, act within an individual. So overall, the powerful sense of smell guides a feline’s social life.

When two cats meet, for further intel, a cat check out another’s butt odors. In Why Cats Sniff Rear Ends, veterinarians Ryan Llera and Lynn Buzhardt compare the feline practice to two people who meet, assess physical features and body language, and then quickly greet each other with an expression of recognition or affection – or ignore each other. 

The aromas produced provide information to one cat what her new-found friend likes to eat and what sort of mood she is in. By simply smelling a companion, a cat can determine whether they are male or female, happy or aggressive, or healthy or ill.

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The science behind the signature smells of animals

The distinct smell emanates from the openings of the paired anal glands tucked inside the rectum, and are emitted during defecation. When a relieved feline rockets around with the zoomies from a satisfying dump, we humans are usually too preoccupied laughing to notice the odoriferous secretions. And even if we are paying attention, the pungent poop masks the smells from the anal glands.

The key to deciphering this unique smell in all animals is found in our microbiome, the collection of microbes that live in or on an organism. In humans, the microbiome accounts for 90 percent of a person’s cells, packed in because bacterial cells are so much smaller than ours. These microscopic residents live under our arms, between our toes and butt cheeks, in our guts and noses and spleens and eyebrows and, well, everywhere. It’s omnipresent in the butt of cats. 

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To identify the source of the smell in cats, the feline research team catalogued the microbiomes of domestic cat anal glands. The bacterial members of the microbiome, produce and release organic compounds that affect the behavior of a newly-encountered cat. The investigators identified the “volatile organic compounds” (VOCs) that the anal glands emit, thanks to those microbes. 

For those who fondly remember the functional groups of organic chemistry, the volatile organic compounds, the VOCs that spew from cat rears are alcohols, aldehydes, esters, and ketones. We can’t smell these emissions, but in cats they influence mating, aggression, and marking territory, and probably some behaviors of which we humans aren’t aware.

In cats, info embedded in anal scents supplements that from mere head rubbing.. Will the pair of felines approach and touch, or one jump back and hiss? The scents are so personal that a pair of cats can tell if they’re already acquainted, a little like recognizing someone in a gym who routinely emits a distinctive odor of dirty socks.

Not surprisingly, a dominant cat takes the lead in sniffing the other’s butt and may hiss if displeased. A shy cat may back off and even sit to squelch the emissions, like a shy human at a party retreating to a back room. Among our four felines, it’s clear who the aggressor is — Milton.

An explanation from microbiology

In the new UC Davis study, Connie Rojas and colleagues used the tools of genetics (DNA sequencing), protein chemistry (mass spectrometry), and microbiology (culturing) to identify the components of the anal secretions. They compared the DNA sequences of a gene commonly used in evolutionary investigations to identify bacterial species residing in domestic feline anal glands. 

The material came from 23 domestic cats cajoled and dragged to the UC Davis Veterinary Medical Teaching Hospital for innocuous, elective procedures like cleaning teeth, for which cats are sedated. Owners gave written permission for their cats to take part in the study, but the cats were not consulted. I know that Milton would not have consented to have his anal glands interrogated.

Comparing anal gases of various species reveal, perhaps not surprisingly, that dietary differences underlie the distinctions. The domestic cat anal gland microbiome has a signature of four types (genera) of bacteria: CorynebacteriumBacteroidesProteus and Lactobacillus, with a few scant others. 

What about other species?

  • A dog’s anal glands share species of Bacteroides and Proteus with domestic cats, but also harbor Enterococcus.
  • The wild spotted hyena, with its meaty diet, houses Anaerococcus, Eubacterium, Porphyromonas and Proprionibacterium, but shares Corynebacterium with cats. 
  • At the other end of the dietary spectrum from carnivores is the bamboo-loving giant panda. It’s anal gland microbiome shares Corynebacterium with cats, but in addition houses Pseudomonas, Porphyromonas, Psychrobacter and Anaerococcus.
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Baby giant panda. Credit: D. Chandler

The comparative contributions of the bacterial brew also vary among cats. It’s a little like comparing soups that have the same components, but in differing amounts — say, a tomato-rich minestrone versus a more bean-based concoction or onion soup with a smidge of tomato.

Age and body size also influence the nature of the domestic cat anal gland microbiome. The obese cats among the group had slightly different compositions, but the sample was too small to tease any meaning from this observation. The study also didn’t consider participants’ health other than bad teeth, diet, and the “overall living environment.”

The genetic analysis indeed showed that the bacteria living in the anal glands could be responsible for making the hundreds of released organic compounds. Presumably, the aerosol of organic compounds affects the host animal’s behavior by binding to receptors on specific cell types, such as neurons, eliciting the characteristic response — like the actions of hormones and pheromones.

The researchers hope to continue and expand the study to include more domestic cats as well as other feline species. It’s intriguing to think that a bunch of bacteria can control such traits as mating and mood in a large, willful, multicellular creature. 

I love when chemistry explains biology.

Ricki Lewis has a PhD in genetics and is a genetics counselor, science writer and author of Human Genetics: The Basics. Follow her at her website or X @rickilewis

Race, gender and science: Should positionality statement ‘identity biographies’ be mandatory on science research papers?

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In Defense of Universalism in Science

In a November article in Science magazine, journalist Rachael Zamzow informs us that many social scientists believe that every published paper should include in its author details a “’positionality statement’ describing how their identity might influence their work”. For example, Zamzow writes declaring “race, ethnicity, geographic location, sexual orientation, gender identity, disability status, and career level”. 

Defending such a practice, one researcher quoted in the piece maintained that it is “an invitation to think more broadly about your role as a researcher”. To illustrate the supposed benefits, an imaginary case is offered: 

If you’re an astronomer …, think about where your telescope is…. ‘Are you part of that community? Is that telescope put there with knowledge of the people who call that place their land?’

We, as scientists and educators, believe that although some might find this an interesting and important question for a sociological or ethnographic study, it has nothing to do with, in this example, the value of a report concerning a heavenly body discovered using that telescope. How a disclosure of the astronomer’s sexual orientation would add anything to the understanding of the matter by a reader of the article in an astronomy journal is puzzling, and comes across like a bad joke.

The call for “positionality statements” reveals a basic confusion about science inquiry, the difference between:

  • The (interesting) description and analysis of the sociological and historical settings in which scientific endeavors are undertaken.
  • The results of research reported in a scientific paper on whatever topic.

If the aim is “to think more broadly about your role as a researcher”, this self-reflection concerns the writer, not the reader, and the latter derives no scientifically critical information from the personal details of the author(s). On the contrary, such knowledge could — more or less (un)consciously — bias the reader’s judgement regarding the content and scientific merit of university research. 

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The intellectual movement behind this type of thinking has variously been known as social constructivism, post-structuralism, deconstructionism and post-modernism. In its current iteration, social scientists embrace the dubious concept of the “cultural construction of knowledge, promoting subjective (and sometimes intuitive) approaches to scientific inquiry. As ecological anthropologist Homauun Sidky, has written, “In their discourse, science and scientific truths (deceptively misconstrued as “absolute truths”) were cast as the embodiment of that hegemonic power and its evils, such as racism, sexism, imperialism, colonialism, militarism, oppression, slavery, white supremacy, the atomic bomb, and the destruction of the biosphere.”

We believe such thinking delegitimizes science and critical thinking. We reject recommendations encouraging scientists to inject their personal biographies or relativistic perspectives into empirical science. Repositioning John Rawls’ famous expression, one could argue that readers should be kept behind a “veil of ignorance” as regards the author(s). This is why a basic principle of peer review — which, notwithstanding its defects, is a pillar of evaluation/advancement in sciences — is anonymity (“blindness”).

Our aim in informing the science and the public should be to reaffirm the intrinsic nature of scientific research as a quest for verifiable truths based on all of the evidence available at that point in time – call it a basic Popperian stance – regardless of subjective conditions and orientations.

In the ideal, in the normative prospect established several decades ago by Robert Merton, Universalism, is a key rule for the process of good research (he postulates five prescriptions popularly known by the acronym CUDOS). The concept may be understood in a double sense:

  • First, it prescribes that research results (laws of nature, facts of history, etc.) are endowed with explanatory power regardless of the historical/social context of their discovery. For example, heliocentrism could theoretically have been ascertained as true by an Aztec or African astronomer or by several other scientists, at anytime and anywhere, rather than Copernicus, a Polish mathematician who, more than likely was building on Islamic Middle Age theoretical heritage.
  • Second, “Universalism’ was identified as an essential component of science by Merton precisely because it makes clear that anybody may contribute to scientific discoveries, whatever their gender, nationality, etc. 

For some post-modernist critics, “science is somehow disreputable because it is the province of European white bourgeois males”; yet, it has been rightly replied that “Mendel … got it right about the wrinkled peas; and it would not have mattered if he had been a black handicapped Spanish-speaking lesbian atheist.” 

That is a truism that epistemic relativists seem unable to grasp.

Signed,

Giovanni Molteni Tagliabue — Como, Italy, Independent researcher in political science and socio-political/legislative aspects of ag biotech

Dorian S. Abbot — University of Chicago, IL, USA, Associate Professor of the Geophysical Sciences

Alexander T. Baugh — Swarthmore College, PA, USA, Associate Professor of Biology

Barry L. Bentle — Cardiff Metropolitan University, UK, Reader in Bioengineering

David J. Bertioli — University of Georgia, USA. Georgia Research Alliance Distinguished Investigator and Professor, Institute of Plant Breeding, Genetics and Genomics

Enrico Bucci — Temple University, Philadelphia, USA, Adjunct Professor in Systems Biology, Sbarro Health Research Organization

John Bullock — Bennington College, VT, USA, Professor of Chemistry

Pellegrino Conte — University of Palermo, Italy, Full Professor of Agricultural Chemistry

Jerry Coyne — The University of Chicago, IL, USA, Professor Emeritus of Ecology and Evolution

Michel De Rougemont — Doctor of Philosophy in Technical Science, Kaiseraugst, Switzerland

Adrian Dubock — Member and Executive Secretary, Golden Rice Humanitarian Board

James E. Enstrom — University of California, Los Angeles, CA, USA, Retired Research Professor (Epidemiology)

Jon Entine — Genetic Literacy Project nonprofit, Cincinnati, OH, USA, Executive Director

Giorio Giovanni — Metapontum Agrobios Research Centre, Metaponto (MT), Italy, Senior Principal Scientist

Jacqueline Gottlieb — Columbia University, NY, USA, Professor, Department of Neuroscience 

Jonathan Gressel — Weizmann Institute of Science, Rehovot, Israel, Professor, Plant & Environmental Sciences

Robert H. Guinn — College of the Desert, CA, USA, Professor, Chemistry

Lakshman Guruswamy — University of Colorado, Boulder, Professor of Law Emeritus

Jason E. Hammonds — Cincinnati Children’s Hospital Medical Center, Cincinnati, OH. Assistant Professor of Infectious Diseases

Nurit Haspel — University of Massachusetts, Boston, MA, USA, Professor of Computer Science

Geoff Horsman — Wilfrid Laurier University, Waterloo, ON, Canada, Associate Professor of Chemistry & Biochemistry

Anna Krylov — University of Southern California, Los Angeles, CA, USA, USC Associates Chair in Natural Sciences and Professor of Chemistry

Marcel Kuntz — University of Grenoble-Alpes, France, Director of Research at Centre National de la Recherche Scientifique (CNRS) 

Klaus-Dieter Jany — Association of Genomics and Genetic Engineering e.V. (WGG), Chairman Linkenheim-Hochstetten (Germany) 

Brian Leiter — University of Chicago, Professor of Jurisprudence; Director, Center for Law, Philosophy & Human Values

Luana S. Maroja — Williams College, MA, USA, Professor of Biology, Chair of Biochemistry and Molecular Biology Program

Alan McHughen — University of California, Riverside, USA, Botany and Plant Sciences, expert in agri-food biotech regulation

Axel Meyer — University of Konstanz, Germany, Professor of Zoology and Evolutionary Biology

Ethan L. Miller — University of California Santa Cruz, CA, USA, Professor Emeritus, Computer Science & Engineering

Henry I. Miller, M.Sc., M.D. — Glenn Swogger Distinguished Fellow, American Council on Science and Health, New York, USA; Founding director of the FDA’s Office of Biotechnology

Sadredin Moosavi — Rochester Community and Technical College, MN, USA, Faculty of Science

Piero Morandini — University of Milan, Italy, Associate Professor of Plant Physiology

Jean-Michel Ortega, CNRS ICP — University of Paris-Saclay, Retired research director

Robert Paarlberg — Harvard Kennedy School, Associate, Sustainability Science

Channapatna Prakash — Tuskegee University, USA, Dean, Arts and Sciences

Marisol Quintanilla — Michigan State University, MI, USA, Nematologist

Gerard Rass — Agronomist-Ecologist (retired), General Secretary of the Global Conservation, Agriculture Network.

Catherine Regnault-Roger — University of Pau and Pays de l’Adour (E2S UPPA), Emeritus Professor, member of French Academy of Agriculture and the National Academy of Pharmacy

Ilya Reviakine — University of Washington, Seattle, WA, USA, Department of Bioengineering

Keith Riles — University of Michigan, MI, USA, H. Richard Crane Professor of Physics

Richard John Roberts — Chief Scientific Officer, New England Biolabs, Ipswich, USA, Nobel Laureate in Physiology or Medicine 1993

Paul Roundy — University at Albany, Albany, NY, USA, Professor of Atmospheric Science

Douglas N. Rutledge — Université Paris-Saclay, France; Muséum national d’Histoire naturelle, France, Guest Researcher, Universidade Estadual de Maringá, Brazil

Abhishek Saha — Queen Mary University of London, UK, Professor of Mathematics

Angelo Santino — Unit Head, Institute of Sciences of Food Production, C.N.R., Unit of Lecce, Vice President, European Plant Science Organization (EPSO)

Julia Schaletzky — University of California, Berkeley, Center for Emerging and Neglected Diseases

Gregory Shearer — Penn State University, PA, USA, Professor of Nutrition and Physiology; Chair, Integrative and Biomedical Physiology Program

Michael Shulman — University of San Diego, CA, USA, Associate Professor of Mathematics

Judith Totman Parrish — University of Idaho, MS, USA, Professor Emerita, Department of Geological Sciences

Roberto Tuberosa — University of Bologna, Italy, Professor in Biotechnology Applied to Plant Breeding, Department of Agricultural and Food Sciences

Ignazio Verde — Council for Agricultural Research and Economics (CREA), Rome, Italy, Research Director

François Vazeille — CNRS France, Former Research Director, Laboratory of Physics Clermont-Ferrand and CERN Geneva (CH)

Jean-Philippe Vuillez — University Grenoble Alpes, France, Professor of Biophysics and Nuclear Medicine

Robert Wager — Vancouver Island University, Canada, Molecular Biology, Biochemistry

James West — Vanderbilt University Medical Center, TN, USA, Professor of Pulmonary & Critical Care Medicine

Does the recently approved Novavax COVID vaccine offer any unique benefits?

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Erin Kissane, a co-founder of the COVID Tracking Project, rolled up her sleeve for the Novavax covid-19 vaccine in mid-October soon after it was finally recommended in the United States. Like many people with autoimmune diseases, she wants to protect herself from a potentially devastating covid infection.

Kissane’s autoimmune arthritis seems to make her susceptible to unusual vaccine side effects. After getting an mRNA booster last year, her joints ached so painfully that her doctor prescribed steroids to dampen the inflammation. She still considers the mRNA vaccines “miraculous,” knowing covid could be far worse than temporary aches.

Nonetheless, when the pain subsided, she pored through studies on Novavax’s shot, a vaccine that is based on proteins rather than mRNA and has been used since early 2022 in other countries. Data from the United Kingdom found that people more frequently reported temporary reactions — like low fevers, fatigue, and pain — as their immune system ramped up in the days following booster vaccination with Moderna’s mRNA vaccine versus the one by Pfizer. And those boosted with Novavax’s had fewer complaints than either of those. That finding was corroborated in an analysis of international data published last year.

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Such studies have driven people with long covid and chronic fatigue syndrome (also known as myalgic encephalomyelitis, or ME/CFS) to seek out Novavax, too, since the FDA and the Centers for Disease Control and Prevention greenlighted Novavax’s vaccine — updated to protect against recent omicron coronavirus variants — about three weeks after recommending updated mRNA vaccines in September.

Waiting paid off for Kissane, whose arm was briefly sore. “It was a dramatically different experience for me,” she said. “I hope that plays out for others.”

Another group who waited on Novavax are biologists who geek out over its technology. When asked why he opted for Novavax, Florian Krammer, a virologist at the Icahn School of Medicine at Mount Sinai, replied on X, formerly known as Twitter: “Because I am [a] vaccine nerd, I like insect cell produced vaccines.”

Whereas mRNA vaccines direct the body to produce spike proteins from the coronavirus SARS-CoV-2, which then train a person’s immune system to recognize and fight the virus, Novavax simply injects the proteins. These proteins are grown within moth cells in a laboratory, while other protein-based shots use cells from mammals. And Novavax has said that a special ingredient derived from the bark of Chilean soapbark trees enhances the vaccine’s power.

Research suggests that the Novavax vaccine is about as safe and effective as the mRNA shots. Its main disadvantage is arriving late to the scene. Vaccine uptake has plummeted since the first shots became widely available in 2021. Nearly 70% of people got the primary vaccines, compared with fewer than 20% opting for the mRNA covid boosters released last year. Numbers have dwindled further: As of Oct. 17, only 5% of people in the United States had gotten the latest covid vaccines, according to the Department of Health and Human Services.

Daniel Park, an epidemiologist at George Washington University, said low rates might improve if people who felt lousy after their last mRNA shots gave Novavax a try. It protects against severe illness, but researchers struggle to specify just how effective this and other vaccines are, at this point, because studies have gotten tricky to conduct: New coronavirus variants continuously emerge, and people have fluctuating levels of immunity from previous vaccines and infections.

Still, a recent study in Italy suggests that Novavax is comparable to mRNA vaccines. It remained more than 50% effective at preventing symptomatic covid four months after vaccination. Some data suggests that mixing and matching different types of vaccines confers stronger protection — although other studies have found no benefit.

Given all this, Park held out for the Novavax vaccine on account of its potentially milder side effects. “Between a demanding full-time job and two young kids at home, I wanted to stay operational,” he said. His arm was sore, but he didn’t have the 24-hour malaise accompanying his last mRNA shot.

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Most people don’t strike a fever after mRNA shots. Even when they do, it is brief and therefore far less detrimental than many cases of covid. In fact, most reactions are so minor that they’re hard to interpret. During clinical trials on mRNA vaccines, for example, up to a third of people in the placebo group reported fatigue and headaches after injection.

People with ME/CFS and long covid — a potentially debilitating condition that persists months after a covid infection — have responded to covid vaccinations in a wide variety of ways. Most participants with long covid in an 83-person Canadian study said their levels of fatigue, concentration, and shortness of breath improved following vaccination. Inflammatory proteins that have been linked to long covid dropped as well.

However, larger studies have yet to corroborate the hopeful finding. Jennifer Curtin, a doctor who co-founded a telehealth clinic focused on long covid and ME/CFS, called RTHM, said vaccines seem to temporarily aggravate some patients’ conditions. To learn how Novavax compares, she posted polls on X in late October asking if people with long covid or ME/CFS felt that their symptoms worsened, improved, or stayed the same after Novavax. Most replied: unchanged.

“It’s not scientific, but we need to figure it out since these folks don’t want to get covid,” Curtin said. “My patients are all wondering about what vaccine to get right now.”

Adding to the uncertainty, the rollout of Novavax and mRNA vaccines has been bumpy as pharmacies struggle to predict demand and insurance companies figure out how to reimburse providers for the shots. Unlike previous vaccine offerings, these options are no longer fully covered by the federal government. A testament to this season’s struggle to get vaccinated is that at least one do-gooder has created an online tool to find open appointments for Novavax.

Buoyed by anecdotes of relief from others with long covid, Hayley Brown, a researcher at the Center for Economic and Policy Research who has the condition, opted for Novavax recently. Unfortunately, her symptoms have flared. She said a temporary discomfort will still be preferable to risking another infection. “As someone with long covid, the idea of getting covid again is terrifying.”

Amy Maxmen is a science journalist in New York City who covers the entanglements of health, climate, policy and of the people behind research. Find Amy on X @amymaxmen

A version of this article was originally posted at Kaiser Health News and is reposted here with permission. Any reposting should credit both the GLP and original article. Find Kaiser Health News on X @KHNews

Viewpoint: Are ESG — environmental, social and governance — goals the next step in corporate citizenship or an activist imposition?

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Corporate ESG (Environmental, Social and Governance) performance measurements have recently polarised the business community. Many see it as the next evolutionary step in corporate citizenship after product stewardship and Corporate Social Responsibility while others see it as an activist imposition of certain subjective concepts of sustainability encouraged by consultants and investment fund managers.

Certain critical attacks in the investment world, legal challenges and a political backlash in the U.S. have slowed the growth of ESG as a corporate game-changer. But while the recent backtracking by American investment firms would suggest that ESG has passed its moment, this year the European Commission’s Corporate Sustainability Reporting Directive (CSRD) has come into effect, demanding that every company of a certain size comply to report on the

Social and environmental risks they face, and on how their activities impact people and the environment

This process though is not just a tick-box table that a company needs to fulfil or a series of checks to ensure their labs are safe. If that is how CSRD is interpreted in a seed company, then the organisation is not very forward-looking and will likely not do well long-term.

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The ESG chain

In an integrated food chain, a demand to create a more sustainable food and agriculture system will ultimately come back to the seed. Food manufacturers and processors are going through their ESG reporting process and are quick to conclude that they can be more sustainable if they “source more responsibly”, i.e., pass the responsibility for reducing the environmental impact of the food they process, package, and distribute upon the farmers who grow them.

To earn ESG points then, the downstream users are imposing restrictions up the food chain, upon the farmer (fewer pesticides, reduced fertilisers, water management, regenerative techniques…). Of course, food companies are also demanding that farmers grow abundant quality food at prices they are willing to pay them. Earlier this year, I spoke to farmers struggling to meet a major food manufacturer’s demand to be supplied with no-till potatoes (an agricultural technique that would offer them more ESG points). It should come as no surprise that many farmers don’t care too much for corporate bean counters and their ideas of sustainability.

This trend of imposing sustainability demands up the value chain, to the source of production, is not only an agri-food phenomenon. It is also being imposed, for example, on the production processes in the textile, IT, and automotive sectors. After decades of global supply-chain cost-cutting demands that have created social and environmental pressures and compromises on suppliers, downstream users are now insisting this chain become more sustainable. But unlike an offshore textile factory or a chemical converter, a farmer only has so much room and budget for innovation and automation.

This creates a problem, a challenge, and an opportunity: How can we have more sustainable food that is still sufficient and at a reasonable cost (to the consumer, the farmer and the environment)?

Seeding sustainability

Many people with offices in high buildings are calling for an “urgent transition” to a more sustainable food system and are guiding ESG measurement tools toward this objective. The European Commission itself has presented its Farm2Fork strategy within its Green Deal legislation within such ambitions. But in arbitrarily restricting crop protection tools, in reducing fertiliser inputs and prioritising organic farming, the regulators have realised the yield problem they will be creating.

To avoid a major agricultural yield decline following the implementation of Farm2Fork, the European Commission suddenly fast-tracked regulatory support for new genomic techniques (NGTs). To transition to this more sustainable food system, they realised the need for better seeds. The European Commission acknowledges that NGTs “allow precise and efficient development of improved plant varieties that can be climate resilient, pest resistant, require less fertilisers and pesticides, or ensure higher yields.

Every food company and processor who are themselves striving for a more sustainable food supply chain should understand that farmers would be unable to comply without better seeds. Like the European Commission, that was rather slow to the party, the food chain needs to be aware that farmers cannot meet such demands without better seed technologies.

Seed breeders need to step up and engage in the discussion and meet the challenges of a transition to a more sustainable food system that the ESG framework is imposing. Rather than food companies putting unrealistic pressure on farmers, they should be speaking with agronomists and seed breeders to understand what is presently possible and where opportunities for innovations exist.

I once asked a group of seed researchers how often they spoke with food processors, companies, and retailers… and they just smiled. But these researchers are the ones who can provide the sustainable solutions the food industry is demanding. ESG is an opportunity for the entire food chain, but it starts with the seed.

The next time people in your organisation roll their eyes about another ESG or CSRD requirement, remind them that the seed industry holds the key to a more sustainable food system.

David Zaruk is the Firebreak editor, and also writes under the pen-name The Risk Monger. David is a retired professor, environmental-health risk analyst, science communicator, promoter of evidence-based policy and philosophical theorist on activists and the media. Find David on X @Zaruk

A version of this article was originally posted at Seed World and has been reposted here with permission. Any reposting should credit the original author and provide links to both the GLP and the original article. Find Seed World on X @SeedWorldEU

Viewpoint: Never heard of the Heartland Health Research Alliance? Here’s how the organic- and tort-lawyer funded sham research center generates disinformation about glyphosate and other farm chemicals

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Where would science be if an influential institute today was established by tort lawyers to produce research solely for use in fabricated lawsuits?

Where would science be if the researchers at this institute conceive of and design a study on the basis of drawing conclusions to support their politically-driven objectives?

Where would science be if this study is funded via a large organic food company, tort law firms and non-transparent, donor-advised (dark) funding?

Where would science be today if this organization touts scientists who have been charged with research integrity issues?

This is part one of a series. Read part two here.

If this were acceptable, then science would be at the heart of the Heartland Health Research Alliance and their Heartland Study.

The Heartland Health Research Alliance (HHRA) came into existence in 2020 following initial funding from Organic Valley,  a leading organic cooperative with more than $1 billion in annual sales. Organic Valley has financed many anti-pesticide studies and campaigns led by the Heartland founder, Charles Benbrook. At that same time, US tort law firms were investing heavily in lawsuits against Monsanto on glyphosate so HHRA was able to easily attract funding from glyphosate litigators like BaumHedlund (now Wisner Baum), with a leading glyphosate lawyer heading the HHRA board of directors (Weitz & Luxenberg’s Robin Greenwald). All of this was orchestrated by the disgraced litigation consultant and organic food industry advocate, Charles Benbrook, who provided the HHRA with scientific leadership and his network of interested actors.

The objective behind creating HHRA was for it to run the Heartland Study (which was already raising funds from organic and litigator special interests prior to the HHRA formation). The Heartland Study has been designed to associate reproductive issues, birth defects and distressed pregnancies with exposure to herbicides. Assuming these conclusions could be correlated with herbicide traces in hospital urine samples, the organic food industry lobby could create further fear and outrage about herbicide use and tort law firms could sue more pesticide manufacturers for any complications during or after childbirth.

When public-funding opportunities for the Heartland Study started becoming more lucrative, the group quickly erased any links with tort law firms and removed references to the wily maverick, Benbrook and his family members staffing these efforts.

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HHRA removed image of tort lawyer Robin Greenwald from their board page but she is still the vice chair.

The Heartland Health Research Alliance exists, simply, to undermine trust in research, challenge the regulatory system, provide opportunities for law firms and interest groups to enrich themselves while creating fear and outrage within the population against industry and agriculture. The Heartland Study was designed not for discovery or for the benefit of society, but for these Heartland objectives. But greed and deception is not enough to succeed. In committing many foolish transgressions, we find an organization in chaos, lacking integrity and respect.

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Trouble in the Heartland

Everything about the Heartland Health Research Alliance was sketchy from Day 1, from how Benbrook had assured people in the organic food industry he could “ramrod” a study through in record time (if fully funded) to how they have been sending interest group financiers for the Heartland Study through a donor-advised (dark money) foundation fronted by Franciscan nuns.  The recent purification of their website from any traces of scientific impropriety or special interest funding meant a new group was taking over. HHRA was fast becoming Ramazzini West.

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Early brochure directing funders to a (dark) donor-advised fund. Also lists CDC as a partner.

The Ramazzini Institute is a noted partner of the Heartland Study and a research group tied to the Collegium Ramazzini, a members-only club of mostly American occupational health activist scientists who meet once a year in Italy to network and exchange projects and opportunities. Their members have taken very strong political positions, mostly against industry and regulatory science, work regularly as litigation consultants and paid expert witnesses with US tort law firms and use their network to manipulate research findings in their own studies and in the International Agency for Research on Cancer (IARC) monographs (particularly on glyphosate, benzene, aspartame and talc).

Ramazzini fellows on the Heartland boards include the director, Fiorella Belpoggi, Melissa Perry and Philip Landrigan. This network was already sharing funding for different research projects and blurring the lines between research endeavours. As the Ramazzini Global Glyphosate Study had been struggling for funding for years, Philip Landrigan, involved in both this and the Heartland Study, found a way to transfer almost one million dollars from the Heartland Study budget to Ramazzini’s Global Glyphosate Study. This decision was taken by Landrigan and Perry in 2018 but only publicly announced in 2023.

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The Ramazzini influence leaves behind a completely different stench within the Heartland than the tort lawyers and organic food industry lobbyists. Melissa Perry left her lab and academic position at the prestigious George Washington University after certain research integrity issues emerged from her publications. The Ramazzini studies on glyphosate and aspartame have been rejected by the mainstream scientific establishment (although interest groups like NGOs, food lobbies and tort law firms have continued to amplify them). It sets the narrative for how the Heartland Study will likely develop, publish, and amplify their findings.

The Heartland Study

The Heartland Study purports to ‘answer critical questions about the potential impacts of herbicides on mother and infant health, including whether there is a connection between herbicide exposure and birth defects or developmental challenges.’ The study lists childhood health problems such as autism, ADHD, asthma, obesity and leukemia as having been directly linked to the use of herbicides and exposure to ‘toxic chemicals.’

Claiming that the American Heartland (a.k.a. the Midwest) is the epicenter of rising herbicide use in the US, the study aims to enroll 2,000 mother-infant pairs and track their exposure to herbicides and insecticides by taking frequent urine samples, as well as documenting mother and child health over time (throughout pregnancy and at least until age 3 or possibly until children reach the age of 16). Cheek tissue samples are also to be taken, to look for epigenetic changes that would reflect the risk of premature birth or chronic diseases in later life.

Unfortunately, the study is under the control of the HHRA staff, rather than an unbiased research group or double blinded third party as would be expected for a standard clinical trial. What actually comprises the control group to compare test results with is also a mystery. How can one gauge increases in premature birth in the Heartland, if we have nothing to compare the numbers to?

The design of this study seems to be precisely set up to facilitate foul play of some format, whether this is fudging the data or cherry-picking subsets to manufacture a desired result for the Heartland’s interest groups (eg, tort law firms suing pesticide companies or the organic food industry).

Transparency (on a need-to-know basis)

As part of efforts to receive U.S. taxpayer funding for their efforts, Heartland recently claimed they have been awarded the Candid Platinum Seal of Transparency for 2023. This claim was made during the year where HHRA cleansed their website of any information of their funding, former board and staff members with conflicts of interests and any connection with special interest groups that would benefit from their conclusion-directed study. See the HHRA page on the Candid site (which remarkably has a lot of blank sections).

This transparency award claim is absurd. HHRA’s funding is completely dark. Earlier publications had shown how funding had come from interest groups who would benefit from their results (like the organic food industry lobby and tort law firms). Now nothing is published on their funding. The move to direct HHRA financing to donor-advised (dark money) funds like the Franciscan Health Foundation means no one knows who is actually funding the study. This apparently does not trouble the Heartland Study scientific advisory board as some members have a history of not disclosing their conflicts of interest.

There is also a rather cavalier use of Heartland funds quietly redirected for other purposes. Transferring almost a million dollars of Heartland Study funding to the Ramazzini Institute and then disclosing it only five years later (when the organization realized they needed to clean their act up if they would ever get government funding) speaks volumes of how little the Heartland scientists can be trusted. Transparency and conformity take a backseat to their special interests and opportunity.

Conclusion

What we have with this Heartland circus is a group of activist scientists working with interest groups (the organic industry and tort law firms) to non-transparently manufacture evidence that can be used to create fear, outrage, lawsuits and sidestep regulatory science. It reveals a network of sociopathic true believers, opportunists and zealots who have no qualms about misrepresenting data, raising unnecessary fears and over-playing emotional issues. They are doing this to advance their interests, get rich and destroy those they despise by orchestrating an illusion of research to undermine public trust in technologies and regulators.

Heartland represents the demise of evidence-based research showing how greed, deception and avarice can win over facts, innovation and entrepreneurship.

Kathleen L. Hefferon is an instructor in microbiology at Cornell University. Find her on X @KHefferon

David Zaruk is the Firebreak editor, and also writes under the pen-name The Risk Monger. David is a retired professor, environmental-health risk analyst, science communicator, promoter of evidence-based policy and philosophical theorist on activists and the media. Find David on X @Zaruk

A version of this article was originally posted at the Firebreak and is reposted here with permission. Any reposting should credit both the GLP and original article. Find the Firebreak on X @the_firebreak

‘Perhaps GMOs are closer to natural processes than we think’: How genetic modification mimics natural evolution of plants

Genetically modified (GM) crops may be controversial, but similar processes happen naturally with wild plants. However, scientists have long been puzzled about how these processes happen. Our recent study may help researchers solve the mystery.

People often use the “tree of life” as a metaphor to describe the evolutionary relationships between organisms. The more closely related species are, the closer together they appear in the tree.

This is a bit misleading though, as reality is more complicated. Species don’t always split off along their own evolutionary path in isolation from other branches. In fact, in some groups of organisms, connections among branches are so common that we may need to abandon the notion of a tree of life altogether. This is particularly true for bacteria, where the evolutionary relationships look more like a tangled web than a tree. The crosstalk between branches is caused by the movement of genetic information.

Horizontal gene transfer (also known as lateral gene transfer) is the process by which pieces of DNA (such as genes) move between organisms outside of the usual parent to offspring route. It allows genetic information to be shared between distant branches of the tree of life without sexual reproduction, and it is responsible for the rapid spread of traits such as antibiotic resistance among bacteria.

Originally scientists thought this phenomenon was restricted to microbes, but we now know it also happens in a wide range of plantsanimals and fungi, where it can spread the genetic recipe for traits that have an evolutionary advantage.

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Horizontal gene transfer in grasses

Grasses are one of the most important groups of plants and include crops such as rice, wheat and maize. They cover almost 40% of the Earth’s landmass and make up the majority of human calorie intake.

Horizontal gene transfer between grass species has been found in wild and cultivated species alike. While we know these transfers happen from the marks they leave in species’ genomes (the entire set of DNA instructions in a cell), we still do not know the mechanism behind it. Neither do we know how often it happens – something our recent study, published in New Phytologist, aimed to address.

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Grasses make up a large part of humanity’s diet. Credit: Zoran Zeremski/Shutterstock

Understanding the pace of horizontal gene transfer would allow us to assess its impact upon the planet and plant evolution and how quickly it can help plants to adapt to changes. For example, is it common enough that plants could already be using it in response to climate change?

We sequenced several genomes for the tropical grass Alloteropsis semialata to estimate the frequency of gene transfers into this species. Our study retraced the evolutionary history of each gene in the genome, identified genes that were of foreign origin, and worked out when and where they were transferred.

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Alloteropsis semialata is also known as black seed grass. Credit: Marjorie Lundgren, CC BY-SA

Our findings showed that genes were continually acquired throughout the evolutionary history of this species, with a foreign gene incorporated approximately every 35,000 years.

However, this is a dramatic underestimate of the real rate of transfers into the species because it doesn’t show gene transfers that may have been lost afterwards. Most transferred genes are unlikely to give the recipient any benefit – and can even have negative consequences for the plant if they disrupt essential parts of the recipient’s genetic code. Genes that don’t offer the recipient an advantage are often lost. It’s much harder for scientists to detect these kinds of transient genes.

The genes that are retained are generally those that offer the recipient an evolutionary advantage. For example, many of the horizontally transferred genes detected in grasses offer disease resistance, stress tolerance and increased energy production. These genes may have been optimised in the genomes of the donor species for millions of years. Horizontal gene transfer allows the recipient to skip this long refinement process.

GM technology

Ultimately horizontal gene transfer and GM crops have the same outcome: a gene of foreign origin is inserted into a recipient’s genome.

Our study gave an insight into how often horizontal transfers are happening. But we still don’t know how genes are moving between distantly related species. There are many theories but we think a mechanism called reproductive contamination is most likely. It mirrors some of the methods used to make GM crops.

There are several different methods by which you can make a GM plant – some that require intense human intervention and some that don’t. Simple techniques such as repeated pollination or pollen tube pathway-mediated transfer require minimal human intervention. In these methods, small fragments of DNA from a third individual travel down the same pollen tube established by the father to contaminate the embryo in the seed. In theory this could occur naturally.

In the future we plan to test this idea and see if we can recreate some of the natural transfers we have documented. If successful, it may be time to reconsider how we view GM crops. Perhaps they are closer to natural processes than we think.

Luke Dunning is a Natural Environment Research Council Independent Research Fellow at the University of Sheffield. Find Luke on X @LukeTDunning

Lara Pereira is a Postdoctoral Research Associate in Genetics at the University of Sheffield.

Pauline Raimondeau is a Postdoctoral Associate in Ecology & Evolutionary Biology at Yale University. Find Pauline on X @PaulineRaim

A version of this article was originally posted at the Conversation and is reposted here with permission. Any reposting should credit both the GLP and original article. Find the Conversation on Twitter @ConversationUS

Newest Alzheimer’s drug slows disease — but costs over $25,000 per year. Who will pay for it?

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The first drug purporting to slow the advance of Alzheimer’s disease is likely to cost the U.S. health care system billions annually even as it remains out of reach for many of the lower-income seniors most likely to suffer from dementia.

Medicare and Medicaid patients will make up 92% of the market for lecanemab, according to Eisai Co., which sells the drug under the brand name Leqembi. In addition to the company’s $26,500 annual price tag for the drug, treatment could cost U.S. taxpayers $82,500 per patient per year, on average, for genetic tests and frequent brain scans, safety monitoring, and other care, according to estimates from the Institute for Clinical and Economic Review, or ICER. The FDA gave the drug full approval July 6. About 1 million Alzheimer’s patients in the U.S. could qualify to use it.

Patients with early Alzheimer’s disease who took lecanemab in a major clinical trial declined an average of five months slower than other subjects over an 18-month period, but many suffered brain swelling and bleeding. Although those side effects usually resolved without obvious harm, they apparently caused three deaths. The great expense of the drug and its treatment raises questions about how it will be paid for, and who will benefit.

“In the history of science, it’s a significant achievement to slightly slow down progression of dementia,” said John Mafi, a researcher and associate professor of medicine at the David Geffen School of Medicine at UCLA. “But the actual practical benefits to patients are very marginal, and there is a real risk and a real cost.”

To qualify for Leqembi, patients must undergo a PET scan that looks for amyloid plaques, the protein clumps that clog the brains of many Alzheimer’s patients. About 1 in 5 patients who took Leqembi in the major clinical test of the drug developed brain hemorrhaging or swelling, a risk that requires those taking the drug to undergo frequent medical checkups and brain scans called MRIs.

In anticipation of additional costs from the Leqembi drug class, the Centers for Medicare & Medicaid Services in 2021 increased monthly premiums for Medicare patients by 15%, and premiums may rise again in 2024 after a slight decline this year.

Such increases can be a significant burden for many of the 62 million Medicare subscribers who live on fixed incomes. “Real people will be affected,” Mafi said. He contributed to a study that estimated lecanemab and related care would cost Medicare $2 billion to $5 billion a year, making it one of the most expensive taxpayer-funded treatments.

In its analysis, ICER suggested that Leqembi could be cost-effective at an annual price of $8,900 to $21,500. In an interview, David Rind, ICER’s chief medical officer, said $10,000 to $15,000 a year would be reasonable. “Above that range doesn’t seem like a good place,” he said.

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Whatever its price, patients may be delayed getting access to Leqembi because of the relative shortage of specialists capable of managing the drug, which will require genetic and neuropsychological testing as well as the PET scan to confirm a patient’s eligibility. A similar drug, Eli Lilly’s donanemab, is likely to win FDA approval this year.

Already there are long waits for the testing needed to assess dementia, Mafi said, noting that one of his patients with mild cognitive impairment had to wait eight months for an evaluation.

Such testing is not readily at hand because of the paucity of effective treatment for Alzheimer’s, which has helped to make geriatrics a relatively unappealing specialty. The United States has about a third as many dementia specialists per capita as Germany, and about half as many as Italy.

“Time is of the essence” for the neuropsychological testing, Mafi said, because once a patient’s cognitive ability declines below a certain threshold, they become ineligible for treatment with the drug, which was tested only in patients in the earliest stages of the disease.

Mafi’s study estimates that patients without supplemental Medicare coverage will have to pay about $6,600 out-of-pocket for each year of treatment. That could put it out of reach for many of the 1 in 7 “dual eligible” Medicare beneficiaries whose income is low enough to simultaneously qualify them for state Medicaid programs. Those programs are responsible for about 20% of physician bills for drug infusions, but they don’t always cover the full amount.

Some practitioners, such as cancer centers, cover their Medicaid losses by receiving higher rates for privately insured patients. But since almost all lecanemab patients are likely to be on government insurance, that “cross-subsidization” is less of an option, said Soeren Mattke, director of the Center for Improving Chronic Illness Care at the University of Southern California.

This poses a serious health equity issue because “dual eligibles are low-income patients with limited opportunities and education, and at higher risk of chronic illnesses including dementia,” Mattke said in an interview. Yet many doctors may not be willing to treat them, he said. “The idea of denying access to this group is just appalling.”

Eisai spokesperson Libby Holman said the company was reaching out to specialists and primary care physicians to make them aware of the drug, and that reimbursement options were improving. Eisai will provide the drug at no cost to patients in financial need, she said, and its “patient navigators” can help lock down insurance coverage.

“A lot of clinicians are excited about the drug, and patients are hearing about it,” said David Moss, chief financial officer of INmune Bio, a company that has another Alzheimer’s drug in development. “It’s a money center for infusion centers and MRI operators. It provides reasons for patients to come into the office, which is a billing thing.”

Outstanding doubts about Leqembi and related drugs have given urgency to efforts to monitor patient experiences. CMS is requiring Leqembi patients to be entered into a registry that tracks their outcomes. The agency has established a registry, but the Alzheimer’s Association, the leading advocacy group for dementia patients, is funding its own database to track those being treated, offering physician practices $2,500 to join it and up to $300 per patient visit.

In a letter to CMS on July 27, a group of policy experts said CMS should ensure that any and all Leqembi registries create and share data detailed enough for researchers and FDA safety teams to obtain a clear picture of the drug’s real-world profile.

The anti-amyloid drugs like lecanemab have created a polarized environment in medicine between those who think the drugs are a dangerous waste of money and those who believe they are a brilliant first step to a cure, said ICER’s Rind, who thinks lecanemab has modest benefits.

“People are as dug in on this as almost anything I’ve ever seen in medicine,” he said. “I don’t think it’s healthy.”

Arthur Allen, Senior Correspondent, writes about the FDA and the pharmaceutical industry as well as covid-related topics. Find Arthur on X @ArthurAllen202

A version of this article was originally posted at KFF Health News and is posted here with permission. Any reposting should credit both the GLP and original article. Find KFF Health News on X @KFFHealthNews

Glyphosate can harm pregnant women living near farms? Carelessly-written article based on the same authors’ more sober academic study shows how misinformation metastasizes

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Scientists claim in a popular article that glyphosate poses “health concerns”— but what do the data actually say?

Glyphosate is the world’s most used herbicide. That distinction places it firmly in the crosshairs of those that seek to remove safe and effective chemistry from the hands of farmers. And it’s consumers worldwide who in the end will be most hurt by anti-biotechnology advocacy groups that target the weedkiller as a proxy for genetically engineered crop.

We need not look further than court case after court case in which lay juries, not scientists or physicians, have been tasked with determining if this relatively benign herbicide used safely for half a century causes non-Hodgkin’s Lymphoma as activist critics contend. In numerous cases, juries have sided with plaintiffs even though the global consensus holds otherwise.

The best scientific analysis to date, focusing on more than 54,000 high-exposure farmers who applied glyphosate regularly over decades—the USDA’s Agricultural Health Study—showed no non-Hodgkin’s Lymphoma association.

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There have been thousands of studies of glyphosate and only a handful, mostly conducted by outspoken critics of glyphosate and published in obscure or pay-for-play journals, claim to show an association between the herbicide and cancer. And an independent review showed the claimed connection derived from mashing together data sets that were not appropriate to combine, and generated a misleading outcome that grabbed headlines. No wonder the public discussion is pockmarked with negative perceptions.

Despite attempts by glyphosate critics to pressure politicians to ban the herbicide, scientific sanity has so far prevailed. Just last month, after authorizing yet another evaluation that stretched to more than 11,000 pages and concluded there is no unusual risk from application or dietary exposure, the European Union re-approved glyphosate for 10 more years.

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These results comport well with the findings of almost two dozen independent international regulatory bodies over more than a decade of careful assessment. As Health Canada summarized in its review of the herbicide in 2019, “No pesticide regulatory authority in the world currently considers glyphosate to be a cancer risk to humans at the levels at which humans are currently exposed.”

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[View infographic with links to the original assessments here]

How false information on the alleged dangers of glyphosate metastasizes

Despite these unanimous conclusions, the public and social media conversation is muddied with misinformation. The latest incident arose last week with the publication of an article in The Conversation titled “Glyphosate, the active ingredient in the weedkiller Roundup, is showing up in pregnant women living near farm fields – that raises health cancer”.

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The journalistic article was written by two of the eight authors of a July academic paper examining the presence of trace amounts of glyphosate-based herbicides in pregnant women living near farm fields.

Bizarrely dubbed a “Research Brief”, the piece was echoed in the media by a strategically timed, well-oiled glyphosate attack campaign. The coordinator was Carey Gillam, a former Reuters journalist, who was displaced from her position at the news service 8 years ago after widespread allegations of biased reporting about glyphosate. After a stint at the organic-industry funded anti-crop biotech front group US Right to Know, she began writing an anti-glyphosate attack blog last year for the Environmental Working Group, which is largely funded by donations from the organic industry and trial lawyers who have made billions of dollars litigating the alleged dangers of glyphosate.

Gillam placed articles on her EWG website, the UK The Guardian and the Society of Environmental  Journalists webpage coordinated to come out the same day as the release of The Conversation summary piece. Advocacy sites on the web and the discussion site Reddit all simplistically hyping Gillam’s line. This propaganda onslaught added fuel to the ‘confusion inferno’ and serves as a textbook example of how data can be misrepresented and mainstreamed.

Examining the data through the lens of science and not ideology

Ironically, and media hype aside, rather than uncovering health threats to vulnerable women from glyphosate, the hyped study results actually show the opposite: that exposure levels are infinitesimally small and represent a testament to how the herbicide is safely used.

The Conversation article is a synthesis of a study by Curl et al. published last week in Environmental Health Perspectives, a favorite depository for papers produced by longtime critics of crop biotechnology. EHN is notoriously known for a 2015 article, “IARC Monographs: 40 Years of Evaluating Carcinogenic Hazards to Humans,” which insinuated that scientists who criticized the only agency to claim that glyphosate poses a cancer threat —the International Association for Research in Cancer (IARC) — had venal motives.

The academic piece analyzed urine glyphosate levels in 22 pregnant women living within 0.5 km (about 0.3 miles) of a likely agricultural field in southern Idaho where glyphosate might have been applied, and 18 others that lived further away. Urine samples were drawn throughout the growing season, including time points apparently coincident with glyphosate application, and analyzed for detection of glyphosate. As a water-soluble molecule, glyphosate is rapidly removed from the body and analysis of urine serves as a reasonable proxy for exposure.

Curl et al. claimed that glyphosate was detectable in 66% of samples. What does that mean? Today’s analytical methods can detect glyphosate at amazingly small concentrations. In this work, the Limit of Detection (LOD) was 0.1 micrograms per liter, or 100 parts per trillion. That’s equivalent to 1 minute 40 seconds in 32,000 years. It’s pretty amazing that something that rare can even be identified. Bravo science.

While it may seem strange to find any herbicide residue in urine, modern detection methods are so good that some amount of just about any environmental chemical might be found in all of us—almost always at extremely low trace levels. And urine measures are poor proxies for understanding the impact of a chemical on human health. The dose makes the poison (and in this case it was infinitesimally low, and the fact that a chemical is found in urine means that it is exactly where it should be, outside the body.

Moreover, the researchers did not report A Limit of Quantitation (LOQ), which is the range of concentrations that a given chemical may be precisely quantified. This is a strange oversight as showing that something is present at the edge of nothing is very different from saying precisely how much is there at the edge of nothing.

There were other perplexing aspects of the study. Assuming that its data are accurate, approximately 154 to 228 parts per trillion (between 2 minutes 24 seconds and 3 minutes 48 seconds in 32,000 years) were detected on average. The 228 parts per trillion were found in samples obtained during spray season in women living close to farms (it was unclear if the farms actually were sprayed with glyphosate, as 14% of crops on the nearby acreage, including onion and mint, were not glyphosate-tolerant and 35% of alleged agricultural land closest to the residence were reported as “none”, meaning no glyphosate traces were found (see Table 2 in the original article). In other words, there is no reason to assume glyphosate was even used on roughly half of the acres.

The other half of the farms grew corn, sugar beets and alfalfa, three crops that may be glyphosate tolerant but are not always, especially alfalfa. The materials and methods section noted “spray season” as May 1 to August 15, but did not note if spraying was actually observed or performed. All curious assumptions.

This is a modification of Figure 4 from Curl et al, showing the data from the test. Black lines in the box and whisker plot represent the median from each group, showing minor differences. Gray boxes represent the range where half of samples are found during apparent spray season, white boxes from non-spray season. Red and blue arrows were added for this piece to underscore the slight differences and provide a relative time analogy. The green arrow shows the limit of detection. For scale, the purple arrow shows the concentration of herbicide applied in the field—about 600 miles away. Statistical significance does not mean biological significance.

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This is a modification of Figure 4 from Curl et al, showing the data from the test. Black lines in the box and whisker plot represent the median from each group, showing minor differences. Gray boxes represent the range where half of samples are found during apparent spray season, white boxes from non-spray season. Red and blue arrows were added for this piece to underscore the slight differences and provide a relative time analogy. The green arrow shows the limit of detection. For scale, the purple arrow shows the concentration of herbicide applied in the field—about 600 miles away. Statistical significance does not mean biological significance.

How would an objective scientist assess the data?

Glyphosate was detected in the urine of pregnant women at (probably) the same level near or far from farms. The level may have slightly increased during the apparent spray season, as one might expect as a certain amount of the chemical may travel as aerosolized drift. The levels detected were orders of magnitude below demonstrated physiological risk. In sum, the words in the title — “raises health concerns” — are wholly unwarranted. And curiously, that characterization doesn’t accurately represent the data or commentary in the original academic article.

More importantly, The Conversation piece shows how results that infer zero to low risk can be transformed to imply profound danger. The authors of the article cite studies associating urine glyphosate levels with lower gestational time during pregnancy. Indeed, this research has been done, and a correlation has been observed between urine glyphosate concentration and minor deviations in gestation time. The differences observed might translate to a couple of days at the most, and the data come from small experimental cohorts with potentially confounding variables and limitations that the cited study’s authors clearly recognize.

The same work reported that no differences were seen in head circumference or birth weight with urinary glyphosate levels, so while gestation time might be slightly shorter, it did not affect physical attributes of the newborn. A second study shows very small differences in urinary concentrations in pregnant women (e.g., 220 ppt vs 270 ppt) that translate to a percent or two of the European Union’s strict allowable daily intake. In other words, the evidence that the glyphosate has any meaningful impact is extremely thin.

The authors state that there is no consensus that glyphosate is safe-as-used, citing a lone article by Charles Benbrook, an economist who has made a living bashing genetically engineered crops and their associated chemicals. That’s a dubious proclamation considering that 3,000+ studies and more than 280 scientific institutions across the world have found GE crops safe. Genetically engineered crops represent 90-some percent of US corn, canola, soy and cotton acreage, and no health consequences have been found in humans or animals over 30 years of use. The fact that these authors cite this dubious claim and also state that random jury decisions constitute a scientific authority is not just bad scholarship, it is cynical disinformation.

The authors conclude with an argument from ignorance, disingenuously writing “What still isn’t known”. In fact, we know quite a bit after 50 years and thousands of papers and dozens of regulatory assessments. Even their study shows that in spray season, the levels of exposure are far below strict international exposure levels. Even occupational exposure levels have marginal, if any, associations with increased negative health risks. All of this we know.

Consequences of misrepresenting science

What do we make of the odd choices by the authors to frame such flimsy evidence in such a polemical way? To impute certain risk based on a smattering of small studies is irresponsible at best. To infer some sort of association of glyphosate with cancer ignores a robust scientific consensus that has not identified epidemiological or molecular evidence to support hard cancer conclusions.

In the eight years since the International Association for Research in Cancer produced a hazard-based assessment of the literature classifying glyphosate as a “probable carcinogen”, no research study — not one — has shown persuasive links to cancer or any other health malady at from micro-traces in our food. And despite enormous pressure from politicized advocacy groups which have made an opposition to glyphosate their signature issue and major fund-raising tool, regulators around the globe continue to approve its safe use.

Spreading hyperbolic interpretations of published data is dangerous to agriculture and the public. Widely implemented agricultural chemistries are central to farm productivity. It also fans doubt about an oversight process that is widely acknowledged as independent and effective. Regulators pore over data, independent labs exert checks and balances, and payday-seeking attorneys scan the literature for anything that may be distorted into a claim of evidence.

So why would The Conversation, a source with a sound reputation feature a clearly biased article that conjures fear, uncertainty and doubt around a paper that otherwise shows exposure levels are extremely low, even close to farm fields where glyphosate is used?

I understand the pressure to promote one’s research, and I understand that claims of poisoned fetuses get headlines and clicks. But scholars have a professional and moral responsibility to keep interpretations within the data and not infer risk from jury decisions. In the days where trust in science languishes, the public relies on academic scientists to help decipher and contextualize the evidence. In cases like this in which the data show no particular risk and yet the authors grossly exaggerate the findings with claims of ‘health concerns’, carelessly written articles do nothing more than scare the public, irrevocably breaking the already fragile public trust of science.

Kevin M. Folta is a professor, keynote speaker and podcast host. Follow Professor Folta on Twitter @kevinfolta

‘Warrior gene’: Some people may be genetically wired for aggressiveness. Can we—should we—do something about it?

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A near certainty whenever monoamine oxidase A (MAOA) rears its ugly head in popular science writing is that an ugly image will also accompany the article, most often of a bloodied head — Mel Gibson as Braveheart, say, or a screaming Spartan from the movie 300. (Or a blood-splattered viking.) This is hardly surprising: MAOA is, after all, better known as the ‘warrior gene’ and is now inextricably linked with antisocial or violent behavior.

First, a quick background for those who may have missed all the hype. In the 1990s, a variant of the gene encoding monoamine oxidase A was identified in males from a large Dutch family known for a history of extreme violence. This was followed, in 2002, by the first substantive study implicating MAOA in the violent behavior of adults with a history of childhood abuse. Then, in 2004, the moniker “warrior gene” appeared, seemingly as an attempt to spice up an article about MAOA and aggression in rhesus monkeys. Since then, further studies and stories have regularly surfaced – a recent example being research on MAOA and  “extreme criminal violent behavior” in recidivist offenders in Finland. 

Crime, violence and genes create a heady mix that has proved irresistible, especially when combined with the sexy term ‘warrior gene’. And it is here that things turn ugly. The simplistic ‘warrior gene’ concept appears to simply reflect long-established beliefs that violent criminals are irredeemably born that way — the sort of beliefs that led, last century, to odious eugenic policies to cleanse society of the congenitally “unfit”.

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Yet the problem posed by today’s ever-increasing understanding of how genes influence behaviour is the similarly increasing pressure to use that knowledge to intervene; if we know that some people may indeed be born with tendencies that will negatively impact their lives and the lives of others, are we not morally obliged to act? Or, given that aggressive antisocial behavior is concentrated within deprived communities, will this merely reinforce existing prejudices against marginalized groups, and blind us to the social and environmental factors that led to crime? 

The “warrior gene” itself can perhaps be a useful guide here — both as an example of how ill-conceived genetic arguments can have detrimental social outcomes and of how we might navigate the contentious debate in ways that benefit those most in need. And in this respect, the most appropriate image to illustrate any discussion of the warrior gene would be that of a real warrior, especially one with “a twinkling in the eye which cannot indicate anything but cunning and ferocity”. Or rather, this particular warrior could stand as an apt metaphor for the important ethical questions surrounding genetic accounts of antisocial behavior (of which MAOA is the most notorious example). 

Cunning and ferocious” was in fact Charles Darwin’s initial impression of the indigenous Maori “New Zealanders”, recorded in his Voyage of the Beagle diary entry from late 1835. Indeed, he goes on to note that the New Zealanders’ “warlike spirit is evident in many of their customs, and even in their smallest actions” and that “a more warlike race … could not be found in any part of the world.”

In 2006, almost exactly 170 years after Darwin wrote these words, this warlike spirit was evoked by New Zealand researchers in an evolutionary explanation for the high rates of criminality and violence in modern Maori communities — an explanation, moreover, based on the apparent prevalence of MAOA in the indigenous population. In brief, it was suggested that the warrior gene had been positively selected during the violent and risky ancestral Polynesian/Maori migrations across the Pacific, and that the resultant high frequency of this gene could thus account for the warlike nature of early Maori society and modern social dysfunction.   

This warrior gene hypothesis was seized upon by the news media, who reported it in lurid terms as a claim that, say, Maori were “retarded borderline psychotics” or “genetically wired to commit acts of brutality.” The critical reaction was understandably strong — most especially, that this argument merely gave a pseudo-scientific gloss to racist beliefs about the inherently violent nature of Maori. As the Darwin example above demonstrates, such attitudes have existed for generations. The warrior gene hypothesis, however, went further in implying that such behavior was genetically fixed and therefore ineluctable. And if this were indeed the case, why waste taxpayer dollars attempting to address the unsolvable problem of crime and violence in Maori communities?  

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The New Zealand Maori controversy, therefore, neatly illustrates the potential dangers of genetic explanations for socially deleterious behavior, especially for marginalized people. And yet, as a consequence of the widespread negative publicity surrounding the warrior gene, researchers are likely to shy away from genetic studies focused on such people — a reluctance that, in turn, may actually prove detrimental to these groups’ present and future well-being.  

Like indigenous peoples the world over, Maori are over-represented at the wrong end of social indicators of well-being, such as health, education, and the like. It is ironic, therefore, that the actual genetic research from which the warrior gene hypothesis arose was concerned with improving the life-outcomes of Maori people. Specifically, the research focused on the association between MAOA and addiction, and in particular on racial variation in the gene’s frequency and on similar variation in alcohol and tobacco dependence. As data indicated a high prevalence of the gene in Maori, the ultimate aim was to use genetic information in developing more appropriate treatments for alcohol/tobacco addiction amongst Maori (i.e., those statistically more prone to alcohol- or tobacco-related illnesses).

The warrior gene hypothesis itself was incidental to this study, being merely ill-conceived speculation about how high frequencies of MAOA may have arisen in ancestral Maori. And yet this is what received all the attention. By contrast, the main epidemiological focus — into the associations between MAO-A30bp-rp and tobacco and alcohol dependence, and the variation in this gene allele’s frequency between different racial groups — was ignored. And yet, while studies like the latter could provide a better understanding of issues that have serious deleterious effects on indigenous communities, the field has now been needlessly tainted. Thus, the negative impact of the warrior gene controversy was not only in reinforcing racial prejudice and eroding support for ameliorative policies, but also in stymying genetic research of potential benefit to otherwise marginalized groups. 

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Furthermore, this saga highlights the problems inherent in genetic explanations for multifaceted social behaviors such as crime or violence. While MAOA may indeed have an influence on violent crime, this is clearly mediated through innumerable other genetic and environmental influences — a point that can be illustrated by yet another irony of the Maori warrior gene story. According to the genetic data on which the study was based, the highest frequencies of MAOA were not actually found among Maori but rather among Chinese, a group not typically associated with violent crime. If this is indeed the case, it is plausible that the risk-taking traits linked to MAOA may be advantageous in the commercial settings stereotypically associated with Chinese in New Zealand; in the economically-deprived environments faced by many Maori, however, these self-same characteristics may instead be expressed in drug-taking, alcohol abuse or criminal behavior. In other words, given a different social environment, the warrior gene might just as readily be described as an entrepreneurial gene. 

To draw these various arguments together. We increasingly have the wherewithal to trace aspects of human behavior — including antisocial behavior — to the underlying effects of gene expression. Nevertheless, as the New Zealand warrior gene controversy demonstrates, this must be done in a manner that is sensitive to the social and historical context, and to the possibility of misrepresentation or sensationalism in the public domain. Nor does this just apply to attention-grabbing social phenomena such as crime and violence. 

A widely-reported study of the genetic determinants of young people’s academic success ended with the well-intentioned call to “use DNA tests at birth to identify children at genetic risk for developing reading problems and give them early intervention”. Yet, while this may indeed “be of particular help for those children who are likely to struggle the most”, these children are also more likely to come from socially and economically deprived backgrounds. Hence, as with the MAOA research discussed above, this risks reinforcing existing social prejudices, though in this case about intelligence rather than violence.  

Successfully navigating the social and ethical obstacles here may prove even more difficult than discerning the complex genetic and environmental factors that influence behavioral outcomes. But surely it is beholden on us to try. And here we can return to New Zealand, to one of the most comprehensive investigations into human development in the world. The decades-long Dunedin Multidisciplinary Health and Development Study has unearthed many important facts about human behavior, including the link between MAOA, childhood abuse and violence in adulthood. And after a lifetime as one of the study’s lead researchers, psychologist Terri Moffat concludes:  

All people are not created equal. Some have real gifts and talents, and some have real problems right out of the starting block. Once we accept that, we can’t dodge the responsibility for social action.

A version of this story originally ran on the GLP on October 9, 2018.

Patrick Whittle has a PhD in philosophy and is a freelance writer with a particular interest in the social and political implications of modern biological science. Follow him at patrickmichaelwhittle.com. Find Patrick on X @WhittlePM

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