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Time for an upgrade? Swedish study reveals thousands of genetic sequences not found in human reference genome

Katarina Zimmer&nbsp|&nbsp
[I]t’s hard to study genetic sequences if they’re absent from the human reference genome, the product of the $2.7 billion ...
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Blood test reveals epigenetic modifications that could predict life-threatening type 2 diabetes complications

Katarina Zimmer&nbsp|&nbsp
Chronically high blood sugar levels in type 2 diabetes can damage tissues throughout the body, such as the nerves, eyes, ...
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Exploring origins of the female orgasm. Is it an ‘evolutionary throwback’?

Catherine Offord&nbsp|&nbsp
The female orgasm might have evolved as part of a biological mechanism to induce ovulation, according to findings published [September ...
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Viewpoint: We aren’t ready for biomarkers that could predict how long we’ll live

John Loike, Ruth Fischbach&nbsp|&nbsp
Over the past several years, scientists have identified four genetic and molecular biomarkers that potentially predict human and animal longevity ...
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Harmless mutations may cause serious illnesses when combined together, case study shows

Chia-Yi Hou&nbsp|&nbsp
In 2008, pediatric cardiologist Deepak Srivastava treated a newborn baby who suffered from acute heart failure and had to be put on ...
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We’re different. We’re the same. Genomic databases require diversity to illuminate human commonalities and disparities

Bob Grant&nbsp|&nbsp
I edited this month’s Critic at Large essay, a piece from Jackson Laboratory Scientific Director Charles Lee on the need to inject large-scale genomic ...
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‘Beneficial archaic DNA’ still present and impacting humans today

Jef Akst&nbsp|&nbsp
Most Neanderthal variants exist in only around 2 percent of modern people of non-African descent. But some archaic DNA is ...
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Meet Garlic, China’s first ever cloned cat

Nicoletta Lanese&nbsp|&nbsp
Devastated by the death of his previous cat, Garlic, Huang [Yu] sought the services of biotechnology company Sinogene. The Beijing-based ...
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Biological passports? How anti-doping organizations catch cheating athletes

Anna Azvolinsky&nbsp|&nbsp
As athletes experiment with drugs that can help give them an edge over their competition, they tweak their strategies to ...
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Processed foods key factor in uptick in colorectal cancer among young adults?

Katarina Zimmer&nbsp|&nbsp
Although still rare, affecting roughly 4 percent of adults over their lifetimes, according to the National Cancer Institute, colorectal cancer is becoming ...
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Transplant shortage? Don’t generate human organs in animals, use stem cell technology to develop organoids

John Loike, Robert Pollack&nbsp|&nbsp
Xenotransplantation experiments, generating human organs in animals for transplantation, are being conducted in sheep, pigs, and, recently, in nonhuman primates ...
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Infographic: How fecal transplants work against recurrent C. diff infections

Kendall Powell&nbsp|&nbsp
Today’s data show that fecal transplants cure 80 percent to 90 percent of patients with recurrent C. diff infections—and doctors ...
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Researchers may get better access to marijuana if DEA follows through on latest pledge

Ashley Yeager&nbsp|&nbsp
[August 26], the Drug Enforcement Administration announced plans to create new regulations to expand scientific and medical research on marijuana ...
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This company wants to freeze your T cells for future cancer treatments. Experts call the idea ‘unproven’

Nicoletta Lanese&nbsp|&nbsp
A new cryopreservation bank offers customers the chance to stash away their T cells for use in future cancer treatments ...
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Personalized nutrition companies are more hype than help, scientists say

Shawna Williams&nbsp|&nbsp
Vitamins and other dietary supplements are a $30 billion industry in the US. In addition to the bottles lining drugstore ...
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Scientists extract ‘near-complete’ HIV genome from 50-year-old tissue sample found ‘sitting in a drawer’

Nicoletta Lanese&nbsp|&nbsp
Scientists extracted a near-complete HIV-1 genome from a lymph node that had been preserved in wax for more than 50 ...
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Exercise creates a ‘unique microbiome’ in our guts. We don’t know why.

Ashley Yeager&nbsp|&nbsp
Teaming up with microbiologists and toxicologists from Rutgers and a pathologist from Oklahoma City, [researcher Sara] Campbell designed an experiment ...
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Infographic: ‘Why not print cancer?’ Here’s what we learn from building glioblastoma on a chip

Jef Akst&nbsp|&nbsp
If arranging cells in a particular formation was a good way to build cancer models that mimic what’s going on ...
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‘It’s very encouraging’: Experimental gene therapy shows promise for glioblastoma patients in clinical trial

Ruth Williams&nbsp|&nbsp
An inducible, tumor-localized gene therapy has been tested for the first time in glioblastoma patients. The two-part approach, which involves ...
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Infographic: Building personalized cancer vaccines

Elaine Mardis, Jasreet Hundal&nbsp|&nbsp
To create an individualized cancer vaccine, researchers must identify cancer-specific peptides called neoantigens, then use a cell-, protein-, or nucleic ...
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Which is more important to the gut microbiome? Genetics or environment?

Nicoletta Lanese&nbsp|&nbsp
Genetics hold far more sway over the mouse microbiome than transient environmental exposures, researchers reported July 26 in Applied and ...
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Can these turtle embryos change their sex by finding warmer or cooler spots within their eggs?

Katarina Zimmer&nbsp|&nbsp
At 27.9 °C, roughly equal numbers of female and male turtles will emerge from the nests of the Chinese pond ...
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Price of progress: Debating the ethics of charging families to participate in stem cell trials for autism

Hannah Furfaro&nbsp|&nbsp
During four visits to Panama over nine months, Aaron [a 9-year-old boy with autism] received infusions of stem cells harvested ...
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Fighting cancer by stimulating the immune system with injections directly into the tumor

Emma Yasinski&nbsp|&nbsp
This past April, Mount Sinai oncologist Joshua Brody and his team announced a clinical trial that delivers immune modulators directly ...
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Human-monkey chimeras created in China in quest to grow transplantable human organs

Nicoletta Lanese&nbsp|&nbsp
An international team of researchers has created embryos containing both human and monkey cells, the Spanish newspaper El País reported July ...
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Priming the body’s immune system with personalized cancer vaccines

Elaine Mardis, Jasreet Hundal&nbsp|&nbsp
In 2014, at Washington University School of Medicine in St. Louis, six melanoma patients received infusions of an anticancer vaccine ...
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Stem cell therapies could treat diabetes by helping the body boost insulin production

Eric Bender&nbsp|&nbsp
Each year, 40,000 people in the United States are diagnosed with type 1 diabetes, an auto­immune disease that wipes out ...
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